DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and mics-1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001343863.1	Gene:	mics-1 / 179475	WormBaseID:	WBGene00011890	Length:	293	Species:	Caenorhabditis elegans

Alignment Length:	206	Identity:	49/206 - (23%)
Similarity:	77/206 - (37%)	Gaps:	51/206 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1406 PPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTA 1470
            ||..:::|.....|...          .|.::....|....::..|||.:.:     ||...|..
Worm     5 PPQEDTVFNTDSDPVYE----------HHAALVSSPFHADEDHTFDISFAAE-----ATDDMTFN 54

  Fly  1471 SATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG-------NKVGIYVHDVA 1528
            ..|:....:|          |||.|.|..|.:. ..||..|..:.||       ..:||||..|.
Worm    55 DTTTDGNGQE----------SVPLEALTVVEIE-KTSKGFGFNIVGGTDNPHFVGDIGIYVSSVN 108

  Fly  1529 VGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEIS--KLTDTVTMLVQNKLHTLKQIKDEPGD 1591
            ..|.| :..:|.||:||.::|:|::..|.::|.....  |:.....||:               |
Worm   109 SESKS-YGVVRTGDKILSFDGIDMTYKTHDEAVEVFRSVKIGHVAKMLI---------------D 157

  Fly  1592 SFYIRVGFDRT 1602
            ..|:.:..|||
Worm   158 REYLHLQEDRT 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	26/87 (30%)
		SH3_DLG5	1594..1657	CDD:212794	4/9 (44%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
mics-1	NP_001343863.1	PDZ_signaling	71..145	CDD:238492	23/75 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810