Protein Alignment Dlg5 and magu-4

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_501805.2
• Gene: magu-4 / 177860
• WormBaseID: WBGene00009678
• Length: 1084
• Species: Caenorhabditis elegans
• Alignment Length: 1794
• Identity: 330/1794 - (18%)
• Similarity: 565/1794 - (31%)
• Gaps: 787/1794 - (43%)

  Fly   188 MVAVEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNVLSLTEELNQLLSEKDNVLQEH 252
            ||.||.   |.|.:.:|:|.|       ||::.|:...::.|.|       .||..||    .|.
 Worm     1 MVEVEA---KPSSLSVEEDEN-------ENEEEKLEDVEKEKLV-------KQLKFEK----AER 44

  Fly   253 QKMSDDLVLANKEIERLKKDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKELENSK 317
            :::::::            ::::...|.|.::      |.|...:.||.       .||:::
 Worm    45 RRIAEEM------------EKEIREVEAKWME------KVRKASEERDD-------IGKKID--- 81

  Fly   318 ELEKLRKSLEKALSEVERSSQDAEEA-KRVR-DWAISQR--EKIVQERDSVKTLCDKMRHERDKA 378
            |.|:...||:..:...|....:.||| ||:| .:...||  |:.:|||..|.....:...|||:.
 Worm    82 EFEEKIDSLQIQVHRSETYKMEIEEANKRLRLQYEALQRDYEETMQERSIVLEENSRQNEERDRL 146

  Fly   379 ISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVE 443
            ..:......|||::...|.:.:....|||..||:..:.|....|:.:|            |.|.|
 Worm   147 QKEIEKMKEDSEEVAALKQKLENTRRLLKVNMEETAQANARKEAAIAR------------LTEAE 199

  Fly   444 LSGYEHTSD-----------------------------------LGIIL-----DDSNKRKLVCG 468
            .:|...|.:                                   |||:|     ||.:   :|.|
 Worm   200 QNGARITEERDEALRKCQQTTGDAIVDIWNTHSVQINLPFNKPNLGIMLGGGRTDDGS---IVHG 261

  Fly   469 ------VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAY 527
                  :...||....||..|.|..||::....:.:|.|:..:..|....|::..|:..:|....
 Worm   262 PIYVRQIAHGSPFDNVLKKLDHIMMVNDISVTDMDERSVMGMLSNCHHIHLVIRRRSNCNKISDV 326

  Fly   528 SVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLM 592
            .:.|     :...||:|..||||...|.|..|                  |...:...:.|:.:|
 Worm   327 CLPL-----NYGVGLELSNGVFINSCEPNGAA------------------SRSGLAPGQRVVHVM 368

  Fly   593 NDPRSDGLNL-FALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEF 656
            :.|..|..:. ..:|..::.|..|:..|:.:.|
 Worm   369 HTPVYDAKHAEMLIKNSREPLVIGILQSTKRGD-------------------------------- 401

  Fly   657 FFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWP 721
                                             .|..:|.::.:|:|                |.
 Worm   402 ---------------------------------HNGKDKHRQTIFSR----------------WF 417

  Fly   722 RTNISHENPTGTMRGNEKKRALMSLFTAGPINVDK-DDELM---GEVGVPEKQPAALIQDQLPPP 782
            ..|          .|::|:|.:::     ..|:|: :|:::   |.:.:|:..||::
 Worm   418 SRN----------GGSDKERTVVA-----KANIDRSNDQVLLRQGSLRMPQASPASM-------- 459

  Fly   783 LPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTA 847
                                                                             
 Worm   460 ----------------------------------------------------------------- 459

  Fly   848 EEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITP-SGDFYQPKTSGQQAQQQVMN 911
                      :||:            |||:.....:..|::.|. ..|....:.:.:......::
 Worm   460 ----------SPLV------------RYGSLRAPTYSSSIDHTKLMLDALDKRFNAKSTAHSEIS 502

  Fly   912 ASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPP 976
            :|||:|...:.|.|.|.           .|..|:       ...|..|..:::|......:...|
 Worm   503 SSSTAAPTALWSPSSVN-----------EKDLVF-------AGTNIEGVPVYVPKSTIFSTPTSP 549

  Fly   977 VGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGG 1041
                  |..|..|||.:                 ||.:.|...|               .||:.|
 Worm   550 ------VTRLIRQNSEQ-----------------KRTMSQISSH---------------RGGWDG 576

  Fly  1042 FLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYH 1106
                                      |..|..|..|......:...|.::         |.::..
 Worm   577 --------------------------RSFSSNTTTSDARPYSMHFTPTSS---------TIMEGK 606

  Fly  1107 PHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIP 1171
            ||..:...:..||                                                   |
 Worm   607 PHRRSAVYSPSHP---------------------------------------------------P 620

  Fly  1172 SNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGN 1236
            ..|::...|.|.|                      ||:|:|.|.|    |:|..|.|..|
 Worm   621 VYPTIRDDSMSSV----------------------MSSSNSIRLP----STSFSNQYPNN----- 654

  Fly  1237 GTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKS 1301
               |:..:.||.|        :|..|
 Worm   655 ---STCSLTGGSG--------VPPRH--------------------------------------- 669

  Fly  1302 LGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTM 1366
                  |.:..|..|  :::...:||.                                  |:.
 Worm   670 ------CISKDGSDF--SISTTGSAMH----------------------------------SYA- 691

  Fly  1367 LVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAP 1431
                          ||..|.:                         :.||..
 Worm   692 --------------EGRSNKK-------------------------YHLPRG------------- 704

  Fly  1432 LSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAET 1496
             :|.|                                    .|.:.:...:|.|...|.|
 Worm   705 -NHHS------------------------------------ESLLVNRSSQPRLVEVPRS----- 727

  Fly  1497 LRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAA 1561
                          .:||.|||.:|| :.:.::||     .:.:||.||..:|..:...|.|.|.
 Worm   728 --------------DVKLCGGNAIGI-LAEKSIGS-----DLLEGDLILSIDGNCVRNTTLECAM 772

  Fly  1562 NEISKLTDTVT-MLVQ---NKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDN 1622
            |.:|.....:| :|||   ::|:.|:...|  ||||::||..||:.| |:|:|.....:|::||.
 Worm   773 NTLSADNSELTGLLVQDGGDRLNRLRLGAD--GDSFFLRVNIDRSME-NKDELDLKCGDVVFVDK 834

  Fly  1623 TVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRRK 1687
            |:..|..|.|||||:|..|.::|.|.|||...|.:.:|
 Worm   835 TMLMGKTGRWRAWKVDKEGRQREHGAIPSSTTVYQAIR--------------------------- 872

  Fly  1688 KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMV 1752
                            :|...:.||          ..:|:.||.||:.::||||:.|.:.|..:
 Worm   873 ----------------ANRYANPFP----------KKAYEWVEKLDTKVKRPVLLFGAVVEPFL- 910

  Fly  1753 RLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKND----RR 1813
            ::.:|.|:.|.:....::..|.:.:...||:.:.:|.::..:.::...|  :|.|...|    ..
 Worm   911 QMLVDESDKFSIVARESLTASLDEVSALLKDKVLIDSKQNDDVYDLYHV--VSTAHIMDITAQGL 973

  Fly  1814 HCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRD-FGTDKISAKAAKEMYERAMKLETDY 1877
            ||:|.|..||::||:|.:::||::.:||||.||::|:.: ...:|||:|.||::.|:.:|:|.|.
 Worm   974 HCVLQVDQSAIDRLKRCRMFPILVKIRFKSVKQLKDVNEHICGEKISSKEAKQLIEKDLKIEKDL 1038

  Fly  1878 KQYISAVIP---GVS--IKHMCTQIKDAVDKEQDKLLWV 1911
            ...::.|:|   .||  :.|...|:|..::.||.|::||
 Worm  1039 DGSVTLVVPSHNNVSFMMTHAVLQLKKIIEDEQKKIVWV 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951	57/231 (25%)
		PDZ_canonical	441..516	CDD:467153	24/120 (20%)
		PDZ_canonical	540..609	CDD:483948	16/69 (23%)
		PDZ3_DLG5-like	1288..1370	CDD:467248	6/81 (7%)
		PDZ_canonical	1498..1576	CDD:483948	21/78 (27%)
		SH3_DLG5	1594..1657	CDD:212794	27/62 (44%)
		NK	<1773..1905	CDD:450170	43/141 (30%)
magu-4	NP_501805.2	Smc	<29..>228	CDD:440809	53/249 (21%)
		PDZ	240..318	CDD:214570	20/80 (25%)
		PDZ	<335..394	CDD:214570	18/76 (24%)
		PDZ_canonical	718..788	CDD:483948	25/94 (27%)
		SH3_DLG5	807..869	CDD:212794	27/62 (44%)
		NK	<955..1071	CDD:450170	39/117 (33%)