DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and mpz-4

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_500654.1	Gene:	mpz-4 / 177255	WormBaseID:	WBGene00019165	Length:	402	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	86/382 - (22%)
Similarity:	133/382 - (34%)	Gaps:	113/382 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   431 PSSYEGEDLLEV--ELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDC 493
            |:||  :.|:|.  ||...:..:.||::    |:..||..|..:||..|.:...|:|.:||....
Worm    51 PNSY--KMLVEATFELPKKDKITQLGLV----NRHGLVTRVHYASPFKGAILPGDIILQVNGTTV 109

  Fly   494 QSLSKRMV--LDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQN 556
            ....|::.  :||....|.    |.|..:..||...:.. ||.....||.|..|..|.:.|| .|
Worm   110 SFDEKQLTEHVDETTGGAS----LQSNVKTVKRKPTTTP-KTEPVRAPHSLYPDFKVVVGKI-LN 168

  Fly   557 SLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSA 621
            |    :.|..:...|..:.|:.  |...|...:....|...|...|:..||:|    .|:.....
Worm   169 S----KSETKITVLVARLKNRM--STSKIPNGILATQDHTIDLAILYQFKYLQ----LGLNVQQV 223

  Fly   622 QTDSI------DSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDA 680
            ....:      ||:.|.|...|                                         :|
Worm   224 DRKVVVNYTIPDSVSHCSLNIG-----------------------------------------EA 247

  Fly   681 IAALDSVLSENSSEKSKENLFNRKKRTKKEKEAS---KSMGTWPRT----NISHENPTGTMRGNE 738
            |.|:|        :|....|.:.::|.::..||:   :.:..:|.|    |:........||..|
Worm   248 IIAVD--------DKPINTLADNRQRFREGFEANGWIRLLVEYPNTDPIKNMVRGQLANVMRTAE 304

  Fly   739 KKRALM-----SLFTAG-----------PINVDKDDELMGEVG-------VPEKQPA 772
            :.:.|:     ..|..|           ||.  |::|..||||       |.:|.||
Worm   305 RPQYLLCGDVRKYFVEGIEALKNGKALAPIL--KEEEGPGEVGKKKSDAKVTKKDPA 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492	21/80 (26%)
		PDZ_signaling	533..592	CDD:238492	15/58 (26%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
mpz-4	NP_500654.1	PDZ	<81..130	CDD:381812	14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900