DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Mpdz

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	1849	Identity:	351/1849 - (18%)
Similarity:	572/1849 - (30%)	Gaps:	661/1849 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 LAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGD--ENQKLKVLLSQESKNVLSLTEELNQL 241
            |..:.|.|.:.|.||.:.|            .:||||  ...||.:|     |:||.     :.|
Mouse     2 LETIDKNRALQAAERLQSK------------LKERGDVANEDKLSLL-----KSVLQ-----SPL 44

  Fly   242 LSEKDNVLQEHQKMSDDLVLANKEIERLKKDE----QLARAEIKVLQLANADLKKRDLLKSRDSS 302
            .|:..|:....|::.|.:.:|.  :.....|.    |.:.|.|       ::|:...||.|.:..
Mouse    45 FSQILNLQTSLQQLKDQVNIAT--LATAAADHAHTPQFSSAVI-------SNLQSESLLLSPNHG 100

  Fly   303 WSKEFP--------SGKELENSKELEKLRKSLEK-----------------ALSEVERSSQDAEE 342
            ..:..|        .||  ....||::|.|::.:                 ..|.|...|::..|
Mouse   101 NLEALPGPGAPAVMDGK--PTCDELDQLIKNMAQGRHVEIFELLKPPCGGLGFSVVGLRSENRGE 163

  Fly   343 ----AKRVRDWAISQREKIVQERDSV-----KTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDE 398
                .:.:::.:::.|:..::|.|.:     :.|...:.|::..:|            ::|.||.
Mouse   164 LGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAISI------------LQKAKDT 216

  Fly   399 AQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSG------YEHTSDLGIIL 457
            .|..|          .|.:|.. .|..|.|..||:..       .:|.      ::|...:.::.
Mouse   217 VQLVI----------ARGSLPP-VSSPRISRSPSAAS-------TISAHSNPMHWQHVETIELVN 263

  Fly   458 DDSN---------------KRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRA 507
            |.|.               |..|..||....   |:|...|.|.|:.:.|...:|...|...:|.
Mouse   264 DGSGLGFGIIGGKATGVIVKTILPGGVADQH---GRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 325

  Fly   508 CAPRSLLLVSRTRHSKRHAYS-----------------VQLKTRDRDCPHGLQLDM--------- 546
            |..|..|:::|....:..|.|                 |...|:..|......:::
Mouse   326 CGNRVKLMIARGAVEETPASSSLGITLSSSTSSTSEMRVDASTQKNDESETFDVELTKNVQGLGI 390

  Fly   547 --------------GVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRS 597
                          |:|:..|.::|...::..:.:||:::::
Mouse   391 TIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAV----------------------- 432

  Fly   598 DGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLK 662
            ||.||           .|.|...|    ::.::|.     |.....:...|..|:.||...|...
Mouse   433 DGTNL-----------QGFTNQQA----VEVLRHT-----GQTVRLTLMRKGASQEAELTSRGDT 477

  Fly   663 FSKPGTPEDNFEQEHDDAIAALDSVLSENSS----EKSKENLFNRKKRTKKEKEASKSMGT-WPR 722
            ......|.:|.|::.:..      .|..|:|    |:....|.:.:....::.:...::.| |.|
Mouse   478 AKDVDLPAENCEKDEESL------SLKRNTSILPIEEEGFPLLSAELEEAEDVQQEAALLTKWQR 536

  Fly   723 -------------TNISHENPTG-TMRGNEKKRALMSLFTAGPI----NVDKDDELMGEVGV--- 766
                         :..|..:..| ::........:.|:...||:    .:...|||:...|:
Mouse   537 IMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLL 601

  Fly   767 -PEKQPAALIQDQLP------------PPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVS 818
             ...|....|..:||            ||:                 |:....:.:.|.:.....
Mouse   602 GENHQDVVNILKELPIDVTMVCCRRTVPPI-----------------ALSEMDSLDINDLELTEK 649

  Fly   819 ALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNH 883
            .....|...|...|..|......: ...|||| |.|:......|.:..::..|:
Mouse   650 PHIDLGEFIGSSETEDPMLAMSDV-DQNAEEI-QTPLAMWEAGGQSIELEKGSR----------- 701

  Fly   884 RLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVF 948
            .|..:|....|...|      |...::..|....|.....|.:..|.         |...|.|:
Mouse   702 GLGFSILDYQDPIDP------ANTVIVIRSLVPGGIAEKDGRLFPGD---------RLMFVNDI- 750

  Fly   949 HPPPLPKNSSGSNMFMPLHPTRG----------SHPPPVGQPPDVVSLKSQNSIESILSAKSPAI 1003
                   |...|.:...:...:|          :.|.|:......||.|....:.|..:.|...:
Mouse   751 -------NLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSAKEDAFLCSPHACKESGL 808

  Fly  1004 SEYGMY----AKRHVPQA-----VRHVPKYPSDSESIGS------GVHGGYGGFLQSNHMPGNRH 1053
            |:..::    |....|.|     .|...::..|::|:.|      .:|.|    ..|:.|
Mouse   809 SDKALFRADLALIDTPDAESIAESRFESQFSPDNDSVYSTQASIFSLHDG----TCSDGM----- 864

  Fly  1054 TQLFPTFGPGGRGNRRSSPLTLPSPPP----------------------QQQLQQLPAATAPHDS 1096
                 .:||           :|||.||                      |..||:..|.:.|.|.
Mouse   865 -----NYGP-----------SLPSSPPKDVTSSSEVVLGLHLSLEELYTQNLLQRQHAGSPPTDM 913

  Fly  1097 VGIPTD----LDYHPHHHTQTNAM--------PHPHPHPHAP------------------YLDYG 1131
            ...||.    .||     |.|||:        |...||...|                  ||...
Mouse   914 RPAPTSGFPISDY-----TTTNAVEQKYECANPVAWPHSQLPSSLSTSELAPALPAVAQKYLTDQ 973

  Fly  1132 HGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPS--------NPSVASKSSSMVKNSS 1188
            ..|.                           .|.:.:.:.|        ..::|..|||:....|
Mouse   974 SSLA---------------------------SDAESVNLQSMSQEAFERTVTIAKGSSSLGMTVS 1011

  Fly  1189 GSIDHHYVTSTGPVSGGSMS-----------ASSSDRAPMSLMSSSI------HNSYGANIAGGN 1236
            .:.|...|.....:.||::|           .|.::.:.:||.::..      |:..|.:|....
Mouse  1012 ANKDGLGVIVRSIIHGGAISRDGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKFSA 1076

  Fly  1237 GTGSS-------------------IGVGGGGGG-------GSGRGSPMPQVHVEVLSHGGGGSGK 1275
            .....                   :..|...||       .|..|..:|:     |.....|.|:
Mouse  1077 APADDRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPE-----LPEREEGEGE 1136

  Fly  1276 RNSNVPADFLCPGDLRRVTIDKR-DKSLGITIQCNNNGG----------GIFVSTVADKSTAMRA 1329
            .:....|.:......|||.:.:. .|||||:|......|          |||:..|.:.|.|.:.
Mouse  1137 ESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKN 1201

  Fly  1330 G-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPIN 1393
            | |:.||:::||.|:::|.|:.|.|...:|:.|:....:||                    |.||
Mouse  1202 GTLKPGDRIIEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ--------------------SIIN 1246

  Fly  1394 HSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDM 1458
            .     ||.||.|...:||:|   :....||.|               |.|||:
Mouse  1247 R-----PRKSPLPSLPHSLYP---KYSFSSTNP---------------FADSLQ----------- 1277

  Fly  1459 PSSAATTTTTTASATSTVYDEEPKPSL---PPPPASV----------PAETLRYVTLHMDKSKNL 1510
                    .||..|.|....|..||:|   ||...||          |:.|.  |:...||....
Mouse  1278 --------LTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATA--VSEDEDKEDEF 1332

  Fly  1511 G-----IKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDT 1570
            |     |:...|:..| .:|.:.         :.||.          ||:....|.|
Mouse  1333 GYSWKNIQERYGSLTG-QLHVIE---------LEKGQ----------SGLGLSLAGN-------- 1369

  Fly  1571 VTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAW 1635
                           ||....|.:| ||.|.||....|....:.||:|.::..:..|
Mouse  1370 ---------------KDRTRMSVFI-VGIDPTGAAGRDGRLQIADELLEINGQILYG-------- 1410

  Fly  1636 KLDAMGHRKECGII---PSQMKVEEELRSGEVVD----CDTGTARRGSTSARRSFFRRKKNQRSS 1693
                ..|:....||   ||::|: ..:|:.:.|:    | .|.|....:|...|  .:.|.....
Mouse  1411 ----RSHQNASSIIKCAPSKVKI-IFIRNADAVNQMAVC-PGIAADSPSSTSDS--PQNKEVEPC 1467

  Fly  1694 SRDSTEIASFSNTQLSFFPDLGLLNDDGG 1722
            |..|...|..|:  |:....|.|..|.||
Mouse  1468 STTSASAADLSS--LTDVYQLELPKDQGG 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	39/184 (21%)
		CENP-F_leu_zip	229..360	CDD:287450	29/163 (18%)
		DUF1090	<326..408	CDD:284007	15/107 (14%)
		PDZ_signaling	439..516	CDD:238492	20/97 (21%)
		PDZ_signaling	533..592	CDD:238492	8/81 (10%)
		PDZ_signaling	1290..1369	CDD:238492	29/90 (32%)
		PDZ_signaling	1497..1576	CDD:238492	14/83 (17%)
		SH3_DLG5	1594..1657	CDD:212794	17/65 (26%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611	21/78 (27%)
		PDZ_signaling	140..222	CDD:238492	15/103 (15%)
		PDZ_signaling	256..335	CDD:238492	18/81 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372		2/23 (9%)
		PDZ	375..464	CDD:214570	15/131 (11%)
		PDZ_signaling	553..622	CDD:238492	13/68 (19%)
		PDZ_signaling	694..777	CDD:238492	16/116 (14%)
		PDZ_signaling	994..1064	CDD:238492	13/69 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144		4/23 (17%)
		PDZ_signaling	1151..1242	CDD:238492	29/90 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313		12/34 (35%)
		PDZ	1349..1434	CDD:214570	27/140 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473		5/25 (20%)
		PDZ_signaling	1483..1563	CDD:238492	5/12 (42%)
		MPDZ_u10	1564..1625	CDD:293272
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611
		PDZ	1626..1710	CDD:214570
		PDZ_signaling	1722..1802	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810