Protein Alignment Dlg5 and DLG3

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_006724688.1
• Gene: DLG3 / 1741
• HGNCID: 2902
• Length: 849
• Species: Homo sapiens
• Alignment Length: 998
• Identity: 227/998 - (22%)
• Similarity: 382/998 - (38%)
• Gaps: 315/998 - (31%)

  Fly  1049 PGNRHTQLFPTFGPGGRGNRRS------SPLTLPSPPPQQQLQQLPAATAPHDSVG-IPTDLDYH 1106
            ||....|:...:|||| ||..|      |..||||        |..|...|..... |||..|..
Human    28 PGYGDWQVPDPYGPGG-GNGASAGYGGYSSQTLPS--------QAGATPTPRTKAKLIPTGRDVG 83

  Fly  1107 PHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGP-------------YMGVGG-------------- 1144
            |       ..|.|.|....|.|:     |.||             |..|.|
Human    84 P-------VPPKPVPGKSTPKLN-----GSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLER 136

  Fly  1145 GVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHY-------------- 1195
            |.||:|.:| .||.     ||.  .:|.:|.:.  .:.::...:.::|...
Human   137 GNSGLGFSI-AGGI-----DNP--HVPDDPGIF--ITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

  Fly  1196 -----------VTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGG 1249
                       :...|||.  .:........|.::|..::       :.|..|.|.||
Human   192 SEVVHSRAVEALKEAGPVV--RLVVRRRQPPPETIMEVNL-------LKGPKGLGFSI------- 240

  Fly  1250 GGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGG 1314
                                .||.|  |.::|.|                             ..
Human   241 --------------------AGGIG--NQHIPGD-----------------------------NS 254

  Fly  1315 IFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLV---------- 1368
            |:::.:.:...|.:.| ||:||:||.|...|::....|.|...|:...|...:.|
Human   255 IYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLND 319

  Fly  1369 QYNPEKFPSIEYEGAHN-LEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPL 1432
            .|.|..:.|.....|.| :...|.:.:.|:...:.|         :|.|  ||.|.||   .:|:
Human   320 MYAPPDYASTFTALADNHISHNSSLGYLGAVESKVS---------YPAP--PQVPPTR---YSPI 370

  Fly  1433 SHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETL 1497
            ....:.::.||                                   .||
Human   371 PRHMLAEEDFT-----------------------------------REP---------------- 384

  Fly  1498 RYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQA 1560
            |.:.||.. |..||..:.|| :..||:|..:..|.|:|.:| :|:||:||..|||:|...|.|||
Human   385 RKIILHKG-STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448

  Fly  1561 ANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIRV--GFD 1600
            |..:.:...:||::.|          :|:|.|::             ::.....|.|:|.  .:|
Human   449 AAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYD 513

  Fly  1601 RTGE--LNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSG- 1662
            ||.:  |....|.|...::|:|.|.   .....|:|..:...|..::.|:|||:.:||::.|:.
Human   514 RTRDSCLPSQGLSFSYGDILHVINA---SDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARL 575

  Fly  1663 EVVDCDTGTARRGSTSARRS----------------FFRRKKN--QRSSSRDSTEIASFSNTQLS 1709
            :.|...   ||.|...:.||                |::.|:|  |.||.::....::.|:::.|
Human   576 KTVKFH---ARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESS 637

  Fly  1710 FFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC--------- 1765
                  ....:...|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Human   638 ------SKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRR 696

  Fly  1766 --EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAV 1824
              ||...|    .|:|.||:.:::|.|::..:..:....|::::: .|.....:|||||||.:|:
Human   697 DNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV-RAVAERGKHCILDVSGNAI 760

  Fly  1825 ERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVS 1889
            :|||:.|:|||.:.::.||.:.:.::    ..:.:.:.|.::|::|||||.::.:|.:|::.|.|
Human   761 KRLQQAQLYPIAIFIKPKSIEALMEM----NRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDS 821

  Fly  1890 IKHMCTQIKDAVDKEQDKLLWVP 1912
            ::.:..:||..::.:....:|||
Human   822 LEEIYNKIKQIIEDQSGHYIWVP 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	16/89 (18%)
		PDZ_signaling	1497..1576	CDD:238492	31/80 (39%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		Guanylate_kin	1737..1904	CDD:279019	51/181 (28%)
		NK	<1773..1905	CDD:302627	38/131 (29%)
DLG3	XP_006724688.1	MAGUK_N_PEST	52..130	CDD:402306	24/97 (25%)
		PDZ_signaling	131..208	CDD:238492	12/86 (14%)
		PDZ_signaling	224..310	CDD:238492	27/150 (18%)
		PDZ_assoc	311..385	CDD:402299	20/138 (14%)
		PDZ_signaling	384..462	CDD:238492	32/94 (34%)
		SH3_DLG3	502..568	CDD:212962	19/68 (28%)
		Guanylate_kin	658..836	CDD:395500	51/182 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810