DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and DLG1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_004078.2	Gene:	DLG1 / 1739	HGNCID:	2900	Length:	926	Species:	Homo sapiens

Alignment Length:	1133	Identity:	257/1133 - (22%)
Similarity:	419/1133 - (36%)	Gaps:	371/1133 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 PVRKQQVYDVFH-----PPPLPK--------------NSSGSNMFMPL-------------HP-- 968
            |||||......|     ...|.:              |...||:|..|             :|
Human     2 PVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

  Fly   969 -TRGSHPPPVGQPP---DVVSLKSQN-SIESILSAKSPAISEYGMY-----AKRHV-PQAVRHV- 1021
             .|.....|: ||.   ::.||.|.. :.|::.|:.||::.:|...     .:.|: ||....|
Human    67 IDRSKPSEPI-QPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVI 130

  Fly  1022 -PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPP------ 1079
             |:....||...|.:...: ||:..:|:...:.|:                 ..|||||
Human   131 GPELVHVSEKNLSEIENVH-GFVSHSHISPIKPTE-----------------AVLPSPPTVPVIP 177

  Fly  1080 ----PQQQ---LQQLPAATAP-----HDSVGIP-----TDLDYHPHHHTQTNAMPHPHPHPHAPY 1127
                |.:.   |..:|.|..|     .||:..|     ||.||.....|
Human   178 VLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT---------------- 226

  Fly  1128 LDYGH-GLGIGPYMGVGGGVSG---------------VGGAIYEGGTFPRKKDNQRLRIPSNPSV 1176
            |:.|: |||    ..:.||...               .|||..:.|         |||:  |..:
Human   227 LERGNSGLG----FSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG---------RLRV--NDCI 276

  Fly  1177 A------------SKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYG 1229
            .            ||:...:| .:|||...||....|||...|....
Human   277 LRVNEVDVRDVTHSKAVEALK-EAGSIVRLYVKRRKPVSEKIMEIKL------------------ 322

  Fly  1230 ANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVT 1294
              |.|..|.|.||                           .||.|  |.::|.|
Human   323 --IKGPKGLGFSI---------------------------AGGVG--NQHIPGD----------- 345

  Fly  1295 IDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLR 1358
                              ..|:|:.:.:...|.:.| ||:||:||.|..:.:...|.|.|...|:
Human   346 ------------------NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALK 392

  Fly  1359 QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTP--RNSPRPPARNSLFPLPMQPQA 1421
            ...|...:.|                 .:|.|...:.|...|  .||...|..|.:.|.....|.
Human   393 NTSDFVYLKV-----------------AKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440

  Fly  1422 PSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLP 1486
            |:: |...:|:|...:.|...|                                   .||
Human   441 PAS-PARYSPVSKAVLGDDEIT-----------------------------------REP----- 464

  Fly  1487 PPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNG 1549
                       |.|.||.. |..||..:.|| :..||::..:..|.|:|.:| :||||:|:..|.
Human   465 -----------RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNS 517

  Fly  1550 VDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGD 1591
            |||...:.||||..:......||::.|          .|:|.|::             ::.....
Human   518 VDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKR 582

  Fly  1592 SFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQ 1652
            |.|:|..||    :...|....|.|...::|:|.|.   .....|:|.::...|...|.|:|||:
Human   583 SLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---SDDEWWQARQVTPDGESDEVGVIPSK 644

  Fly  1653 MKVEEELRSG-EVVDCDTGTARRGST---SARRSFFRRK----KN-----QRSSSRDSTEIASFS 1704
            .:||::.|:. :.|..::.|..:|.:   ..:::.|.||    ||     |.:|..|....::.|
Human   645 RRVEKKERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNAS 709

  Fly  1705 NTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC---- 1765
            :::.|:      ...:...|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Human   710 DSESSY------RGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 768

  Fly  1766 -------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDV 1819
                   ||...|    .|:|.||:.::|:.|::..:..|....|:|:::....:.. :||||||
Human   769 TRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKG-KHCILDV 832

  Fly  1820 SISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAV 1884
            |.:|::|||..|:|||.:.::.||.:.|.::    ..:::.:.|::.:|||||||.::.::.:|:
Human   833 SGNAIKRLQIAQLYPISIFIKPKSMENIMEM----NKRLTEEQARKTFERAMKLEQEFTEHFTAI 893

  Fly  1885 IPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            :.|.:::.:..|:|..::::....:|||
Human   894 VQGDTLEDIYNQVKQIIEEQSGSYIWVP 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	16/79 (20%)
		PDZ_signaling	1497..1576	CDD:238492	30/80 (38%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		Guanylate_kin	1737..1904	CDD:279019	52/181 (29%)
		NK	<1773..1905	CDD:302627	39/131 (30%)
DLG1	NP_004078.2	L27_1	2..62	CDD:370268	12/59 (20%)
		MAGUK_N_PEST	106..223	CDD:371162	30/134 (22%)
		PDZ_signaling	224..308	CDD:238492	23/115 (20%)
		PDZ_signaling	317..403	CDD:238492	30/180 (17%)
		PDZ_assoc	404..465	CDD:371157	18/112 (16%)
		PDZ	463..547	CDD:214570	33/100 (33%)
		SH3_DLG1	582..648	CDD:212964	19/68 (28%)
		Guanylate_kin	735..913	CDD:366206	52/182 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810