DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Patj

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_038965114.1 Gene:Patj / 140581 RGDID:1565362 Length:1858 Species:Rattus norvegicus


Alignment Length:1990 Identity:360/1990 - (18%)
Similarity:623/1990 - (31%) Gaps:695/1990 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 LEKDRNYYRERGD--ENQKL----KVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVL 261
            |::.|...:|:||  :|:||    :.|.|.....:|:|.:.:.||..:..::..:..        
  Rat    16 LDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCS-------- 72

  Fly   262 ANKEIERLKKDEQLARAEIKVLQLANADLKKRDLLKSRDSS--------------------WSKE 306
                                    ||.|..::.||...|.|                    |::.
  Rat    73 ------------------------ANFDFSRKGLLVFTDGSITNGNAHRPCSSITASESLPWTQR 113

  Fly   307 FPSGKELENSKELEKLRKSLEKALSEVERSSQDAEE-----------------AKRVRDWAISQR 354
              ||.| :.:..::::.:.......::||.|.....                 .|.|...:::.|
  Rat   114 --SGNE-DFTSVIQQMAQGRHIEYIDIERPSTGGLGFSVVALRSQSLGLIDIFVKEVHPGSVADR 175

  Fly   355 EKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLD 419
            ::.::|                   :|.::||.|:.               |.:.:..|:...|.
  Rat   176 DQRLKE-------------------NDQILAINDTP---------------LDQNISHQQAIALL 206

  Fly   420 SNASGSRR----------SFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSP 474
            ..|:||.|          ..|.|:...:..|. |...:.||.|:.:|.|.|.....:.|..||..
  Rat   207 QQATGSLRLVVAREVGHTQSRTSTSSADTTLP-ETVRWGHTEDVELINDGSGLGFGIVGGKSSGV 270

  Fly   475 AC------------GKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSR--------- 518
            ..            |:|:..|.|.|:.:.:.|.::...|...:|.|.....:||:|         
  Rat   271 VVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMTSEQVAQVLRNCGNSVRMLVARDPVGEIAVT 335

  Fly   519 ---------------TR-----HSKRHAYSVQLKTRDRDCPHGLQLDM---------------GV 548
                           ||     .|....|:|:|..:|     |..|.:               |:
  Rat   336 PPTPASLPVALPVVATRTLGSDSSPFETYNVELVKKD-----GQSLGIRIVGYVGTAHPGEASGI 395

  Fly   549 FIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLP 613
            ::..|...|.|::..::.|.|::::::..::....:.:.|..|.|..:...|.|...|......|
  Rat   396 YVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASP 460

  Fly   614 ----------------PGMTTS-SAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKL 661
                            |.:|.| ..:|:|....:.:.............|.:.|..:.|      
  Rat   461 FEQPSSREAVAEPPEVPELTGSLKPETNSRMEAEEIGERLDNLRKDTVQALEKPDVYPE------ 519

  Fly   662 KFSKPGTPEDNFEQ--------EHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMG 718
              ..||.||:..:.        :::..:|.||:.::::...:....|.                 
  Rat   520 --DIPGCPENELKSRWENLLGPDYEVMVATLDTQIADDEELQKYSKLL----------------- 565

  Fly   719 TWPRTNISHENPTGTMR-GNE-----KKRALMSLFTAGPIN----VDKDDELMGEVGV----PEK 769
                       |..|:| |.|     ....:.|:...||::    :..:|||:...||    ..:
  Rat   566 -----------PIHTLRLGMEVDSFDGHHYISSIAPGGPVDTLNLLQPEDELLEVNGVQLYGKSR 619

  Fly   770 QPAALIQDQLPPPL----------------PPQMSKPLAHIRGSNGGAIKTHPNRN---SNPVSS 815
            :.|.....::|||.                .|:..:|         ..::...:|:   |.....
  Rat   620 REAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTVEP---------SLLEAEVDRSVDVSTEDDD 675

  Fly   816 GVSALFPPGPPN----------GMPNTSY--PTHPRHS-------------------LYGVTAEE 849
            |..||:.|....          |.....|  |..|..|                   |.|.....
  Rat   676 GELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPMRSVIVIRSLVADGVAERSGELLPGDRLVS 740

  Fly   850 INQKPIQRAPLMGANARVKM--PSQERYG-TRP---------------HSN------------HR 884
            :|:..:..|.|..|...:|.  |.....| .:|               |||            |.
  Rat   741 VNEFSLDNATLAEAVEVLKAVPPGVVHLGICKPLVEEEKEEKEEHFIFHSNNNGDNSESPETVHE 805

  Fly   885 LSLNI---TPSGDFYQPKT------------SGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAA 934
            :..::   .|.|...:|..            ...|.||:.|::||                    
  Rat   806 IHSSLILEAPQGFRDEPYLEELVDEPFLDLGKSLQFQQKDMDSSS-------------------- 850

  Fly   935 GEFPVRKQQVYDV--FHPPPLPKNSSGSNMF--------------MPLHPTRGSHPPPVGQPPDV 983
                    :.:::  |..|.|.:......|.              |..||     |||..:.|..
  Rat   851 --------EAWEMHEFLSPRLERRGEEREMLVDEEYEIYQDRLRDMEAHP-----PPPHIREPTS 902

  Fly   984 VS--------------------LKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDS 1028
            .|                    :...:..||:::|....:.:|. ::...:.:....:...|...
  Rat   903 ASPRLDLQAGPQWLHADLSGGEILECHDTESMMTAYPQEMQDYS-FSTTDMMKETFGLDSRPPMP 966

  Fly  1029 ESIGSGVHGGYGGF--LQSNHMPGNRHTQLFPT--FGPGGRGNRRSSPLTLPSPPPQQQLQQLPA 1089
            .|.|:|.||.:...  |.|....|.....:.|:  .|||       ..:.||:...:::.::||.
  Rat   967 SSEGNGQHGRFDDLEHLHSLVSHGLDLGMMTPSDLQGPG-------VLVDLPAVTQRREQEELPL 1024

  Fly  1090 ATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHG--------------LGIGPYM 1140
            ...|  |..:.|    .|..|....:..|.:.....|..:.|.|              :.|....
  Rat  1025 YRLP--SARVVT----KPSSHVGMVSSRHANAACELPEREEGEGEETPNFSHWGPPRIVEIFREP 1083

  Fly  1141 GVGGGVSGVGGAIYEGGTFPRKKDNQRLR----------IPSNPSVASKSSSMVKNSSG----SI 1191
            .|..|:|.|||..    ...|.|:.:.|:          .|:..:.|.|:...:...||    :.
  Rat  1084 NVSLGISIVGGQT----VIKRLKNGEELKGIFIKQVLEDSPAGKTKALKTGDKILEVSGVDLQNA 1144

  Fly  1192 DH----HYVTSTG-PVSGGSMSASSSDRAPMSLMSSSIHNSYG------------ANIAGGNGTG 1239
            .|    ..:.|.| ||.....|.||:.|...|:      |:.|            ...|..:||.
  Rat  1145 SHAEAVEAIKSAGNPVVFVVQSLSSTPRVIPSV------NNKGKTPPQNQDQNTQEKKAKRHGTA 1203

  Fly  1240 SSIGVGGGGGGGSGRGSPM--------PQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTID 1296
            .               .||        |....|........:.|:.....||.  ||:|..:.::
  Rat  1204 P---------------PPMKLPPPYRAPSADTEESEEDSALTDKKIRQRYADL--PGELHIIELE 1251

  Fly  1297 KRDKSLGITIQCNNNGG--GIFVSTV-ADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLR 1358
            |....||:::..|.:..  .|||..: .|...|....::|||:|||:....:...:.:.|:.:::
  Rat  1252 KDKNGLGLSLAGNKDRSRMSIFVVGINPDGPAAADGRMRVGDELLEINNQILYGRSHQNASAIIK 1316

  Fly  1359 QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRP----------------- 1406
            ......         |...|..|.|.|....:|.     |.|.:||.|                 
  Rat  1317 TAPTRV---------KLVFIRNEDAVNQMAVAPF-----PVPSHSPSPVEDLGGTEPVSSEEDSS 1367

  Fly  1407 ------PARNSLFP----------LPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSS 1455
                  |.|.|..|          :..:.:..|..|.|.|    :.:|...::..:.     |||
  Rat  1368 VDAKPLPERESSKPEDLTQAVDDSMVAEQEKASESPDSAA----RQMKQPGYSAQVS-----SSS 1423

  Fly  1456 QDMPSSAATTTTTT-ASATSTVYDEEPKPSLPPP----PASVPAETLRYVTLHMDKSKN-LGIKL 1514
            |::||:.|....:| |..|.:...:.|....|.|    ||:.|....:.:.:.:.|.:: ||:.:
  Rat  1424 QEIPSAPAPLCQSTHADVTGSGNFQAPLSVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSI 1488

  Fly  1515 FGG-----------NKVGIY--------------VHDV-AVGSPSDHAGIRKGDQILEYNGVDLS 1553
            .||           .|||::              :|:| ..|:.:....:..||||||.|||||.
  Rat  1489 VGGKDTPLPGGSLPTKVGVWEKKLQEMMSQDAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLR 1553

  Fly  1554 GVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVL 1618
            ..:.|:|...:.:....|.:::..                      |.....:|::|     ||.
  Rat  1554 SSSHEEAITALRQTPQKVRLVIYR----------------------DEAQYRDEENL-----EVF 1591

  Fly  1619 YVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQ-------------------MKVE-EELRSGE 1663
            .||.....|     |...|..:|.|...|:..|.                   :.|. |::|...
  Rat  1592 LVDLQKKTG-----RGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQILSVNGEDVRQAS 1651

  Fly  1664 -------------VVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDL- 1714
                         :|..:.|..|.||.::.|      |..::|..|  :.::.|:.:.||.|.: 
  Rat  1652 QETVATILKCVQGLVQLEIGRLRAGSWASSR------KTSQNSQGD--QHSAHSSCRPSFAPVIT 1708

  Fly  1715 GLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRL 1754
            .|.|..|...|....:.......|.|.||..||:.|.|.:
  Rat  1709 SLQNLVGTKRSSDPPQKCTEEEPRTVEIIRELSDALGVSI 1748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 25/155 (16%)
CENP-F_leu_zip 229..360 CDD:287450 21/167 (13%)
DUF1090 <326..408 CDD:284007 12/98 (12%)
PDZ_signaling 439..516 CDD:238492 20/88 (23%)
PDZ_signaling 533..592 CDD:238492 10/73 (14%)
PDZ_signaling 1290..1369 CDD:238492 17/81 (21%)
PDZ_signaling 1497..1576 CDD:238492 25/105 (24%)
SH3_DLG5 1594..1657 CDD:212794 15/82 (18%)
Guanylate_kin 1737..1904 CDD:279019 8/18 (44%)
NK <1773..1905 CDD:302627
PatjXP_038965114.1 L27_2 8..65 CDD:312549 14/48 (29%)
PDZ_signaling 135..218 CDD:238492 18/116 (16%)
PDZ_signaling 248..325 CDD:238492 17/76 (22%)
PDZ_signaling 366..450 CDD:238492 15/88 (17%)
CtpA <391..>511 CDD:223864 18/119 (15%)
PDZ_signaling 572..636 CDD:238492 14/63 (22%)
PDZ 684..773 CDD:214570 14/88 (16%)
PDZ_signaling 1074..1165 CDD:238492 20/94 (21%)
PDZ 1244..1329 CDD:214570 19/93 (20%)
PDZ 1471..1578 CDD:214570 25/128 (20%)
PDZ_signaling 1590..1670 CDD:238492 14/84 (17%)
PDZ_signaling 1731..1816 CDD:238492 8/18 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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