DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Dlg1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_006521824.1	Gene:	Dlg1 / 13383	MGIID:	107231	Length:	939	Species:	Mus musculus

Alignment Length:	1134	Identity:	259/1134 - (22%)
Similarity:	420/1134 - (37%)	Gaps:	360/1134 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 PVRKQQVYDVFH-----PPPLPK--------------NSSGSNMFMPL-------------HPTR 970
            |||||......|     ...|.:              |...||:|..|             :|..
Mouse     2 PVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

  Fly   971 GSHP---PPVGQPP---DVVSLKSQN-SIESILSAKSPAISEY-----GMYAKRHV-PQAVRHV- 1021
            ..|.   .|| ||.   ::.||.|.. :.|::..:.||.:.:|     .:....|: ||....|
Mouse    67 VDHSKQCEPV-QPVTTWEIASLPSTAVTSETLPGSLSPPVEKYRYQDEEVLPPEHISPQVTNEVL 130

  Fly  1022 -PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQ 1085
             |:....||...|.:...: ||:..:|:...:.|:..|...|       ..|:|...|.|.:...
Mouse   131 GPELVHVSEKNLSEIENVH-GFVSHSHISPIKPTEAVPPSSP-------IVPVTPALPVPAESTV 187

  Fly  1086 QLPAATAPH--------DSVGIP-----TDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGH-GLGI 1136
            .||:|...:        ||:..|     ||.||.....|                |:.|: |||
Mouse   188 VLPSAPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT----------------LERGNSGLG- 235

  Fly  1137 GPYMGVGGGVSG---------------VGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKN 1186
               ..:.||...               .|||..:.|         |||:  |..:...:.:.|::
Mouse   236 ---FSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG---------RLRV--NDCILRVNEADVRD 286

  Fly  1187 -----------SSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGS 1240
                       .:|||...||....|.|...|....                    |.|..|.|.
Mouse   287 VTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKL--------------------IKGPKGLGF 331

  Fly  1241 SIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGIT 1305
            ||                           .||.|  |.::|.|
Mouse   332 SI---------------------------AGGVG--NQHIPGD---------------------- 345

  Fly  1306 IQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQ 1369
                   ..|:|:.:.:...|.:.| ||:||:||.|..:.:...|.|.|...|:...|...:.|
Mouse   346 -------NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKV- 402

  Fly  1370 YNPEKFPSIEYEGAHNLEPESPINHSGSPTP--RNSPRPPARNSLFPLPMQPQAPSTRPGSRAPL 1432
                            .:|.|...:.|...|  .||......|.:.|.....|.| |.|...:|:
Mouse   403 ----------------AKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQTP-TSPARYSPI 450

  Fly  1433 SHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETL 1497
            |...:.|...|                                   .||
Mouse   451 SKAVLGDDEIT-----------------------------------REP---------------- 464

  Fly  1498 RYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQA 1560
            |.|.||.. |..||..:.|| :..||::..:..|.|:|.:| :||||:|:..|.|||...:.|||
Mouse   465 RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQA 528

  Fly  1561 ANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIRVGFD-- 1600
            |..:......||::.|          .|:|.|::             ::.....|.|:|..||
Mouse   529 AAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVRALFDYD 593

  Fly  1601 --RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSG- 1662
              :...|....|.|...::|:|.|.   .....|:|.::...|...|.|:|||:.:||::.|:.
Mouse   594 KTKDSGLPSQGLNFRFGDILHVINA---SDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARL 655

  Fly  1663 EVVDCDTGTARRG------STSARRSFFRRK----KN-----QRSSSRDSTEIASFSNTQLSFFP 1712
            :.|..::.|  ||      :...:::.|.||    ||     |.:|..|....::.|:::.|:
Mouse   656 KTVKFNSKT--RGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSY-- 716

  Fly  1713 DLGLLNDDGG---------ALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC--- 1765
             |.|:.|:.|         .|||:.|...:....|||:|:||:.:.:...|..:|.:.|..|
Mouse   717 -LILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPH 780

  Fly  1766 --------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILD 1818
                    ||...|    .|:|.||:.::|:.|::..:..|....|:|::: .|.....:|||||
Mouse   781 TTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSV-RAVAEKGKHCILD 844

  Fly  1819 VSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISA 1883
            ||.:|::|||..|:|||.:.::.||.:.|.::    ..:::.:.|::.:|||||||.::.::.:|
Mouse   845 VSGNAIKRLQIAQLYPISIFIKPKSMENIMEM----NKRLTEEQARKTFERAMKLEQEFTEHFTA 905

  Fly  1884 VIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            ::.|.:::.:..|:|..::::....:|||
Mouse   906 IVQGDTLEDIYNQVKQIIEEQSGPYIWVP 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	16/79 (20%)
		PDZ_signaling	1497..1576	CDD:238492	30/80 (38%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		Guanylate_kin	1737..1904	CDD:279019	53/181 (29%)
		NK	<1773..1905	CDD:302627	40/131 (31%)
Dlg1	XP_006521824.1	L27_1	2..62	CDD:370268	12/59 (20%)
		MAGUK_N_PEST	106..223	CDD:371162	29/124 (23%)
		PDZ_signaling	224..308	CDD:238492	21/114 (18%)
		PDZ_signaling	317..403	CDD:238492	30/180 (17%)
		PDZ_assoc	404..465	CDD:371157	18/112 (16%)
		PDZ	463..547	CDD:214570	33/100 (33%)
		SH3_DLG1	582..648	CDD:212964	19/68 (28%)
		Guanylate_kin	748..926	CDD:366206	53/182 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810