DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Il16

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_006229550.1 Gene:Il16 / 116996 RGDID:1583872 Length:1425 Species:Rattus norvegicus


Alignment Length:1743 Identity:328/1743 - (18%)
Similarity:539/1743 - (30%) Gaps:656/1743 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 QSQQAQNGNSQVPPVGSGNPYY-----FGKTQ--GCDGS-----CSEKLAELKKERNMVAV---- 191
            |.||...| ..|.|.|.|:..|     ..:|.  ||.|:     ||..|...:..|...|.    
  Rat    15 QVQQLGCG-CPVLPAGGGHHQYALWHIHRRTPLLGCQGTAPPPCCSWHLLPGQANRTHAAAAKPS 78

  Fly   192 ----------EREKYKK---SYIELEKDRNYYRERGDENQKLK------VLLSQESKNVLSLTEE 237
                      |:|:.|:   |.:.:|...:..:.|  ::.|.:      :|.:.::.:..|..:|
  Rat    79 SSTTHRPRPGEQERKKRGLTSSLRMEPHSHSGKSR--KSTKFRSISRSLILCNAKTSDDSSSPDE 141

  Fly   238 L------NQLLSEKDNVLQEHQKMSD----------DLVLANKEIERLKKDEQLARAEIKVLQLA 286
            .      ..|..:|:.......:::|          ||.||               :|...||.|
  Rat   142 KYPDPFETSLCQDKEGFFHSSMQLADTSEAGLSNIPDLALA---------------SEAAQLQAA 191

  Fly   287 NAD----LKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRKSLEKALSEVERSSQDAEE--AKR 345
            .:|    .:|...||...::.|||.....|.::|..|      ..||..:..||:..:..  :.|
  Rat   192 GSDRGKHCRKMFFLKESSTTSSKEKAGKSEAQSSNFL------FPKACHQRTRSNSTSVNPYSAR 250

  Fly   346 VRDWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQM 410
            ..|:.::::.....:|... :||...     |::|                              
  Rat   251 EMDFPMTKKSAAPTDRQPY-SLCSNR-----KSLS------------------------------ 279

  Fly   411 EQQERQNLDSNASGSRRSFRPSSYE--GEDLLEVELSGYEHTSDLGIILDDSNKRK-----LVCG 468
                 |.||...||:.|..|..|..  |      :|||....|.:..|:....:.|     :|.|
  Rat   280 -----QQLDYPVSGTARPTRSLSTAQLG------QLSGGLQASVISNIVLMKGQAKGLGFSIVGG 333

  Fly   469 VTS----------------SSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVS 517
            ..|                ::.|.|:|:..|.|.::|......|:.:..|.:.:......|.|..
  Rat   334 KDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESIAGLTHQDALQKFKQAKKGLLTLTV 398

  Fly   518 RTR---------H------------------------------------SKRHAYSVQLKTRDRD 537
            |||         |                                    :.|....|.||   ::
  Rat   399 RTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLK---KE 460

  Fly   538 CPHGLQLDM----------GVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLM 592
            ...||.:.:          ||||..:...|:|..:..|..||.::.||:..:..: ::.||..::
  Rat   461 AGVGLGIGLCSIPYFQCISGVFIHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCM-TLNEVYTIL 524

  Fly   593 N--DPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAE 655
            :  ||                                            |..|...::||.    
  Rat   525 SHCDP--------------------------------------------GPVPIIVSRHPD---- 541

  Fly   656 FFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSM-GT 719
                         |:.: ||:..:|:|            ::.|.:...|:|.:...|..|.: .:
  Rat   542 -------------PQVS-EQQLKEAVA------------QAVEGVKFGKERHQWSLEGVKRLESS 580

  Fly   720 WPRTNISHENPTGTMRGNEKKRALMSLFTAGP--------INVDKDDELMGEVGVPEKQPAALIQ 776
            |      |..||     .||:|...|   |.|        :....|...|.  |.|...|.:...
  Rat   581 W------HGRPT-----LEKEREKHS---APPHRRAQKIMVRSSSDSSYMS--GSPGGSPCSAGA 629

  Fly   777 DQLP---------PPLPP-QMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPN 831
            :..|         |.||| :..:|..        .:.:.|::.|.|:|..:..            
  Rat   630 ELQPSEGEGSTHSPSLPPGEEQEPCP--------GVPSRPHQESPPLSESLER------------ 674

  Fly   832 TSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERY--GTRPHSNHRLSLNIT-PSG 893
               .:||...|.. :.|.:.:||....|        |.|.::.:  .:.|.........:| |||
  Rat   675 ---DSHPPLKLKN-SFEILVRKPTSTKP--------KPPPRKYFKNDSEPQKKLEEKEKVTDPSG 727

  Fly   894 D---------------FYQPKTSGQQ---------AQQQVMNASSTSAGFGVGSGSMVGGTGPAA 934
            .               ..|..|:|:.         .......:|||.   |....|....|..:.
  Rat   728 HTLPTCSQETRELLPLLLQEDTAGRTLCTAACCPGPAASTQTSSSTE---GEPRRSASPETPASP 789

  Fly   935 GEFPVRKQQV-----YDVFHPPPLPKNSSG-SNMFMPLHPTRGSHPP------------PVGQPP 981
            |:.|:.|:|.     :|.....|..:.|.. .|:|.|:.....||.|            ..|.|.
  Rat   790 GKHPLLKRQARMDYSFDSTTEDPWVRISDCIKNLFSPIMSENHSHMPLQPNASLGEEDGTQGHPE 854

  Fly   982 DVVS-LKSQNSIESILSA-------KSPAISEYGMY-------AKRHVPQAVRHVPKYPS----- 1026
            ..:| :.:.|....|..:       |.|.::....:       .:..||: .|..|:..|     
  Rat   855 GGLSKMDTANGAPRIFKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRVPE-TRRAPEVASAIQTT 918

  Fly  1027 ---------DSESIGSGVHGGYGGF--LQSNHMP--GNRHTQLFPTFG-----PGGRGNRRSSPL 1073
                     .|::..|.:......|  ..|:.:|  |.:...|.||.|     ||.:...|.|.|
  Rat   919 PVSRDASGPQSQASSSSIRQRISSFENFGSSQLPDRGVQRLSLQPTSGETTRLPGKQDEGRFSGL 983

  Fly  1074 ----TLPSPPPQQQLQQLPAATAPHDS-VGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHG 1133
                |..:...:|...:.|:.|.|:.| ||.| |:...|        .|...|:|.|        
  Rat   984 PAQGTKVTAKHRQTEVEPPSTTFPNSSEVGDP-DMSESP--------PPGQRPNPKA-------- 1031

  Fly  1134 LGIGPYMGV---------GGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNP--------------- 1174
            |...|.:.:         |.|.               |..:||.|  |.|               
  Rat  1032 LSPDPLLRLLTTQTEDTQGPGF---------------KMPSQRAR--SFPLTRTQSYETKLLDEK 1079

  Fly  1175 -----SVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDR-APMS-LMSSSIHNSYGANI 1232
                 |::|:.||.|..|       .:......|.|.::....:| :|.| ..:|:....:|..:
  Rat  1080 SSKLYSISSQLSSAVMKS-------LLCLPSSASCGQITCIPKERVSPKSPCNNSAAAEGFGEAV 1137

  Fly  1233 AGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRV---- 1293
            |  :.||.|:.:........|...|   ...|..:|....:|:.    ....|...:|:::    
  Rat  1138 A--SDTGFSLNLSELREYSEGLTEP---GETEDRNHCSSQAGQS----VISLLSAEELKKLIEEV 1193

  Fly  1294 ------TIDKRDKSLGITIQCNNNGGG---------------IFVSTVADKSTAMRAG-LQVGDQ 1336
                  |:.:.| |:.:|:.....|.|               |.|..|.....|.:.| :|.|::
  Rat  1194 RVLDEATLKQLD-SIHVTVLHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNE 1257

  Fly  1337 LLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIE----YEGAHNLEPESPINHSGS 1397
            :|.:.|.:::.||...|..:|||..|         |.:...:.    .|.||:|           
  Rat  1258 VLSINGKSLKGATHNDALAILRQARD---------PRQAVIVTRKAIVEAAHDL----------- 1302

  Fly  1398 PTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSA 1462
                                                      .|.|||..:.| ::|...:.|..
  Rat  1303 ------------------------------------------NSSTDSAASAS-VASGISVESVE 1324

  Fly  1463 ATTTTTTASATSTVYD---EEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYV 1524
            ||..|.|...||....   |..|.|                 ||.||...:. ::|.|.:.|   
  Rat  1325 ATVCTVTLEKTSAGLGFSLEGGKGS-----------------LHGDKPLTIN-RIFKGTEQG--- 1368

  Fly  1525 HDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTD-TVTMLVQ 1576
                       ..::.||:||:..|..:.|:|..:|.|.|..|.| .||::::
  Rat  1369 -----------DAVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTVVIR 1410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 42/217 (19%)
CENP-F_leu_zip 229..360 CDD:287450 29/152 (19%)
DUF1090 <326..408 CDD:284007 11/83 (13%)
PDZ_signaling 439..516 CDD:238492 18/97 (19%)
PDZ_signaling 533..592 CDD:238492 15/68 (22%)
PDZ_signaling 1290..1369 CDD:238492 23/104 (22%)
PDZ_signaling 1497..1576 CDD:238492 21/79 (27%)
SH3_DLG5 1594..1657 CDD:212794
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
Il16XP_006229550.1 PDZ_signaling 316..391 CDD:238492 13/74 (18%)
PDZ_signaling 454..536 CDD:238492 22/129 (17%)
PDZ_signaling 1207..1284 CDD:238492 19/85 (22%)
PDZ 1329..1413 CDD:214570 28/114 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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