Protein Alignment Dlg5 and Card10

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_036014949.1
• Gene: Card10 / 105844
• MGIID: 2146012
• Length: 1144
• Species: Mus musculus
• Alignment Length: 662
• Identity: 137/662 - (20%)
• Similarity: 245/662 - (37%)
• Gaps: 153/662 - (23%)

  Fly  1317 VSTVADKSTAMRAGLQ--VGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIE 1379
            |:::......:.|.||  .|...|:.|     |::..:.:|:      |.|..:...|......|
Mouse   554 VTSLEGTKAMLEAQLQRTQGGSCLKAC-----ASSHSLCSNL------SSTWSLSEFPSPLGGPE 607

  Fly  1380 YEG-AHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKD---- 1439
            ..| |...||.:      |....:|.:...|.|:.|.|         |.:.:.|..|..:|
Mouse   608 ATGEAGGSEPHT------SEEATDSEKEINRLSILPFP---------PSAGSILRRQREEDPEPP 657

  Fly  1440 -QSFTDSLENQSDISSSQDM-PSSAATTTTTTASATSTVYD-EEPKPSLP--------------- 1486
             :||:    :.|||:.|..: |.|..   .:::|::.:|:. .:|:..|.
Mouse   658 KRSFS----SMSDITGSVTLKPWSPG---LSSSSSSDSVWPLGKPEGLLARGCGLDFLNRSLAIR 715

  Fly  1487 ----PPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEY 1547
                .|||.:..:         |||.: .:...|....|..|..|..|..|  |...:.:...|.
Mouse   716 VSGWSPPAGLDPQ---------DKSPD-SMPGLGDRWSGAVVRRVLSGPGS--ARTEQKEPRAEG 768

  Fly  1548 NGVDLSGVTAEQAANEIS-KLTDTVTMLVQNK-LHTLKQIKDE----PG-DSFYIRVGFDRTGEL 1605
            .|::.:|:.||.....:. ..:.|:..|:.:| .|:..:..|.    || :.||||..|......
Mouse   769 TGLEGAGLEAEAQQRTLPWNQSSTLPFLLDSKACHSFHEALDAWAKGPGAEPFYIRANFSLPERS 833

  Fly  1606 NEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRK-ECGIIPSQMKVEEELRSGEVVDCDT 1669
            :...|.....|:|.:.:...... ..|...::|.:..|. :.|.:|:..:.::.|   ||.:...
Mouse   834 DPHALCVKAQEILRLVDPAHKRR-QEWFCTRVDTLTLRDLDRGTVPNYQRAQQLL---EVQEKYL 894

  Fly  1670 GTAR----RGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVE 1730
            .::|    |.:...|.....|.|....::.||.|       ||...|...|   :.....|..|.
Mouse   895 ISSRHRSPRSNLKKRALGLVRPKPAGGTAGDSAE-------QLPAEPCSEL---ERSLKPYSLVR 949

  Fly  1731 LLDSPIRRPVLIIGPLSECLMVRLTIDFSNL------FKLCEVTAM----DCSQEA--------M 1777
            .|.....|||::   |.|||..||..:..:|      |::|...::    .|:..|        .
Mouse   950 PLLVSALRPVVL---LPECLAPRLIRNLLDLPSSRLDFQVCPAESLSGEEQCTSSAPGAPKAWPA 1011

  Fly  1778 EEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFK 1842
            ..||           |::     :.||..:.  .::||:|::....|..|...::||||:.:..
Mouse  1012 TAGL-----------GSR-----IRAIQESV--GKKHCLLELGARGVRELVHSEVYPIVIHVEV- 1057

  Fly  1843 SAKQIRDIRDF-----GTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKH---MCTQIKD 1899
            :.|.:|:||..     ..|....:..:...:....|...:.|     :|..:..|   :...::.
Mouse  1058 TEKNVREIRGLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQ-----VPAHAWGHAEELAKVVRG 1117

  Fly  1900 AVDKEQDKLLWV 1911
            .:.:||.:|:||
Mouse  1118 RILQEQARLVWV 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	11/54 (20%)
		PDZ_canonical	1498..1576	CDD:483948	17/78 (22%)
		SH3_DLG5	1594..1657	CDD:212794	12/63 (19%)
		NK	<1773..1905	CDD:450170	24/147 (16%)
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069
		Smc	<262..>573	CDD:440809	4/18 (22%)
		SH3	822..884	CDD:473055	12/62 (19%)