DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and PATJ

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens


Alignment Length:2044 Identity:367/2044 - (17%)
Similarity:647/2044 - (31%) Gaps:692/2044 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KMASGDLSLTSTSSQEEESSEYVGYDNTLRPPSNSSGSTTAANMSNNNGPSKGVSSGVGVSGISG 67
            |:.:.|.:.......:....||:..:   ||.:...|.:..|..|.|.|     ...:.|..:..
Human   113 KLGNEDFNSVIQQMAQGRQIEYIDIE---RPSTGGLGFSVVALRSQNLG-----KVDIFVKDVQP 169

  Fly    68 GNGANYDILQAQYKSALLELN------TLRHQHANTKRRCDELATELTLYQEHYVADRNKFTDMV 126
            |:.|:.| .:.:....:|.:|      .:.||.|                    :|       ::
Human   170 GSVADRD-QRLKENDQILAINHTPLDQNISHQQA--------------------IA-------LL 206

  Fly   127 EESARFKRLLL--ETQNQQSQQAQNGNSQVPP-------------VGSGNPYYF----GKTQG-- 170
            :::....||::  |..:.:|..:.:.|....|             :..|:...|    |||.|  
Human   207 QQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVV 271

  Fly   171 ----CDGSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNV 231
                ..|..:::...|:...:::.:.....:.  :..|:.....|..|:   .:::|::::....
Human   272 VRTIVPGGLADRDGRLQTGDHILKIGGTNVQG--MTSEQVAQVLRNCGN---SVRMLVARDPAGD 331

  Fly   232 LSLTEELNQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLARAEIKVLQLA---------- 286
            :|:|......|......:......||..:.....:|.::||.|  ...|:::...          
Human   332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ--SLGIRIVGYVGTSHTGEASG 394

  Fly   287 --------------NADLKKRDLLKSRDSSWSKEFPSG---KELENSKE---LEKLRKSLEKALS 331
                          |..::..|.:.:.|....:.|.:.   :.|.|:.:   |..:|:....:.|
Human   395 IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTS 459

  Fly   332 EVERSSQDAEEAKRVR------DWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSE 390
            .:|..|......:.::      ..|:.....:..|.:.:|...|.::::..:|:          |
Human   460 PLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQAL----------E 514

  Fly   391 KIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYE-----HT 450
            |::|..|..:.:   ||.:.|         |..|.......::.:.:...:.||..|.     ||
Human   515 KLEKVPDSPENE---LKSRWE---------NLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHT 567

  Fly   451 SDLGIILDDSNKRKLVCGVTSSSP--ACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSL 513
            ..||:.:|..:....:..:.|..|  ..|.|:..|.:.:||.:.....|:|..:..::...|...
Human   568 LRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFT 632

  Fly   514 LLVSRTRHSKRHAYSVQLKTR----DRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDV------- 567
            |:..|.......:.....:|.    :.:..|    :|.|...:.:...||.:.||:.:       
Human   633 LVCCRRLFDDEASVDEPRRTETSLPETEVDH----NMDVNTEEDDDGELALWSPEVKIVELVKDC 693

  Fly   568 ----------------------------------------GDRVLSINNKSMDSVQSIEEVMQLM 592
                                                    |||::|:|...:|:. |:.|.::::
Human   694 KGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNT-SLAEAVEIL 757

  Fly   593 NDPRSDGLNLFALKYVQDQLPPGMT----TSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRF 653
            .                 .:|||:.    ......|:.:...::..:.........|.|.|....
Human   758 K-----------------AVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINS 805

  Fly   654 AEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEK----SKEN------LFNRKKRTK 708
            :..    |:..|....|..|::|..|. ..||...|.:|.:|    |||.      |..|.:...
Human   806 SLI----LEAPKGFRDEPYFKEELVDE-PFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEMD 865

  Fly   709 KEKE------------ASKSMGTWPRTNIS------------------HEN-------------- 729
            :|:|            .|.||..:|.::|.                  |:|              
Human   866 EEREILVDEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTV 930

  Fly   730 -----------PTGTMRGNEKKRALMSL-FTAGPINVDKDDEL------------MGEVGVPEKQ 770
                       |...|:.|....:|.|: .|.|.....:.|:|            :|.:....:.
Human   931 YSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDDLENLNSLAKTSLDLGMIPNDVQG 995

  Fly   771 PAALI----------QDQLP--------------------------------------------- 780
            |:.||          |:.||                                             
Human   996 PSLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEGEGEETPNF 1060

  Fly   781 ----PP------LPPQMSKPLAHIRG-------SNGGAIK---------THPNRNSNPVSSG--- 816
                ||      ..|.:|..::.:.|       .||..:|         ..|...:|.:.:|   
Human  1061 SHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125

  Fly   817 ----------------VSALFPPGPPNGMPNTSYPTHPR---------HSLYGVTAEEINQKPIQ 856
                            |.|:...|.|......|..:.||         :.:.|...::..:|..:
Human  1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK 1190

  Fly   857 R---APLMGANARVKMPS-----------------------QERYGTRPHSNHRLSLNITPSGDF 895
            |   ||     ..:|:|.                       ::||...|...|.:.|....:|..
Human  1191 RQGTAP-----PPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250

  Fly   896 YQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGE---------FPVRKQQVYDVFH-- 949
            .....:..:::..:         |.||    :...||||.:         ..:..|.:|...|  
Human  1251 LSLAGNKDRSRMSI---------FVVG----INPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302

  Fly   950 --------PPPLP----KNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPA 1002
                    |..:.    :|....|. |.:.|    .|.|...|.   |::.|:..|.|.|.:..:
Human  1303 ASAIIKTAPSKVKLVFIRNEDAVNQ-MAVTP----FPVPSSSPS---SIEDQSGTEPISSEEDGS 1359

  Fly  1003 ISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQL----FPTFGPG 1063
            : |.|:   :.:|::...  |....|:.||.|:.......|:  :.|.|..:|:    :||    
Human  1360 V-EVGI---KQLPESESF--KLEDMSQVIGQGMVADQQKALE--YPPDNAVSQMKQQKYPT---- 1412

  Fly  1064 GRGNRRSSPLTLPSPPPQQQLQQLPAATAP--HDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAP 1126
                    .::..|       |::|.|.|.  |.     ||.|:..:...|......|...|..|
Human  1413 --------KVSFSS-------QEIPLAPASSYHS-----TDADFTGYGGFQAPLSVDPATCPIVP 1457

  Fly  1127 YLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQ---RLRIPSNPSVASKSSSMVKNSS 1188
                    |....:.:..|.||:|.:|..|      ||..   ||..|     .:.|..:|:   
Human  1458 --------GQEMIIEISKGRSGLGLSIVGG------KDTPLFWRLGSP-----RAWSQHLVR--- 1500

  Fly  1189 GSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNG---TGSSI-GVGGGGG 1249
            ..:.||.||.   |.|.:              :..||..|....|..:|   .|..| .|.|...
Human  1501 AFMLHHPVTE---VEGQN--------------AIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1548

  Fly  1250 GGSGRGSPM------PQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQC 1308
            ..|.....:      || .|.::.:......:...|:.   :.|.||::    |..:.||::|..
Human  1549 RNSSHEEAITALRQTPQ-KVRLVVYRDEAHYRDEENLE---IFPVDLQK----KAGRGLGLSIVG 1605

  Fly  1309 NNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTML----- 1367
            ..||.|:|:|.:.....|...| |..|||:|.|.|.:||.|:||..|.:|: |......|     
Human  1606 KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK-CAQGLVQLEIGRL 1669

  Fly  1368 -----------------------VQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNS-----P 1404
                                   ...:|...|.|  .|..||.....::   .|:.:||     |
Human  1670 RAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVI--TGLQNLVGTKRVS---DPSQKNSGTDMEP 1729

  Fly  1405 R----------------------PPARNSLFPLPMQPQAPSTRP-----GSRA---------PLS 1433
            |                      |.....:|...:|....:.|.     |.|.         .||
Human  1730 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLS 1794

  Fly  1434 HQSIKD-----------QSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPP 1487
            |..:.:           |...|:  |.|.|::..:..|:.....:.||       :..|:.:..|
Human  1795 HADVVNLLKNAYGRIILQVVADT--NISAIAAQLENMSTGYHLGSPTA-------EHHPEDTETP 1850

  Fly  1488 PPASVPAETLRYVTLHMDKSKNLGIKLFGG-----NKVGIYVHDV-AVGSPSDHAGIRKGDQILE 1546
            ||        :.:||... |:.||..:.||     ..:.|||..| |.|:.:|...:::|||||.
Human  1851 PP--------KIITLEKG-SEGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAADDGRLKRGDQILA 1906

  Fly  1547 YNGVDLSGVTAEQAANEISKLTDTVTMLV 1575
            .||..|.|||.|||...:.....|||:.|
Human  1907 VNGETLEGVTHEQAVAILKHQRGTVTLTV 1935

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 30/207 (14%)
CENP-F_leu_zip 229..360 CDD:287450 22/166 (13%)
DUF1090 <326..408 CDD:284007 13/87 (15%)
PDZ_signaling 439..516 CDD:238492 19/83 (23%)
PDZ_signaling 533..592 CDD:238492 16/109 (15%)
PDZ_signaling 1290..1369 CDD:238492 28/107 (26%)
PDZ_signaling 1497..1576 CDD:238492 32/85 (38%)
SH3_DLG5 1594..1657 CDD:212794
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
PATJXP_011538764.1 L27_2 8..65 CDD:117611
PDZ_signaling 135..218 CDD:238492 19/118 (16%)
PDZ_signaling 246..325 CDD:238492 12/83 (14%)
PDZ_signaling 366..450 CDD:238492 12/85 (14%)
PDZ_signaling 570..634 CDD:238492 13/63 (21%)
PDZ 683..772 CDD:214570 12/106 (11%)
PDZ_signaling 1066..1157 CDD:238492 14/90 (16%)
PDZ 1236..1321 CDD:214570 14/97 (14%)
PDZ 1459..1574 CDD:214570 32/146 (22%)
PDZ_signaling 1586..1666 CDD:238492 30/84 (36%)
PDZ_signaling 1729..1814 CDD:238492 12/84 (14%)
PDZ_signaling 1852..1936 CDD:238492 33/93 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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