DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and dlg5b.1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_021336124.1	Gene:	dlg5b.1 / 101883945	ZFINID:	ZDB-GENE-120206-4	Length:	1907	Species:	Danio rerio

Alignment Length:	2084	Identity:	521/2084 - (25%)
Similarity:	847/2084 - (40%)	Gaps:	596/2084 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GANYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLY--------------QEHYVADRN 120
            |.:|:.::.|...|:.:|.:|::||..|.:||:|.|.:...|              ::...|.:.
Zfish   181 GHDYEHMKLQCMKAMTDLQSLQNQHNKTLKRCEEAARDADYYHTLHARVVGEQTQLRDETEAVKQ 245

  Fly   121 KFTDMVEESARF--------------KRLLLETQNQQSQ-QAQNGNSQVPPVGSGNPYYFGKTQG 170
            |:|.::::....              :|.|.:.:.||.| ..:||:|.:.     |..|
Zfish   246 KYTQLLQQHTHMQQTCDELRHTHDSDQRELQDLRMQQQQVMRENGSSDLL-----NKLY------ 299

  Fly   171 CDGSCSEKLAELKKERNMVAVEREKYKK---------SYIE-LEKDRNYYRERGD---------- 215
              .|...||..||||...:   |::|.:         |.:| ||:::...:::.|
Zfish   300 --DSALNKLEALKKEYEAL---RKRYNEQTALHNADVSRLEQLEEEKRRLQKQRDAALHFQQQYS 359

  Fly   216 --------------------------------ENQKLKVL----------LSQESKNVLSLTEEL 238
                                            ||.:.|.|          |.:|..:|||   |.
Zfish   360 GSMHRFESVQQELNKLSVHNEDLQRETERLQMENTRCKTLQLKAVKDAEKLKEERDSVLS---EY 421

  Fly   239 NQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLARAEIKVL-QLANADLKKRD-------- 294
            ..::||:|.|::|.:|:...|..|..:::....:.::|..|::.| |..|:.|..||
Zfish   422 RLIMSERDQVIKELEKLQSGLEAAEHKLKNTSSERRVAGEEMEALRQELNSALLDRDRAIREKNE 486

  Fly   295 -------------------------------------------------LLKSRDSSWSKEFPSG 310
                                                             ||:....:..|:..:.
Zfish   487 LLEKYCHEVQDKAETQKELSQACKDIEMVREERDVARKERTEAIIQRDQLLREYYQARQKQDSAA 551

  Fly   311 KELEN-SKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHE 374
            .::|. |||||.|||..|....|::.:.|:||.||..||||..:|:|||.||:|::||||.:|.|
Zfish   552 LDMERVSKELEVLRKQCEAVQEELQEALQEAEVAKCRRDWAFQERDKIVAERESIRTLCDNLRRE 616

  Fly   375 RDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQ------ERQNLDSNASGSRRSFRPSS 433
            ||:|:||...|:|:.:.::|||::|.:::..|||.|::|      .||.:..|:..|........
Zfish   617 RDRAVSDLADALRNLDDLRKQKNDAVRELKELKECMDEQLEKEARFRQLMAHNSHDSAIDTDSLE 681

  Fly   434 YEGE--------DLLEVELSGYEHT---------SDLGIILDDSNKRKLVCGVTSSSPACGKLKI 481
            :|.|        |.:::...|::.:         .|.||         .|..|...|.|.|:|::
Zfish   682 WETETVEFQRSTDNMDLSALGFDISEGVSDPYLPGDYGI---------FVSKVDKGSIAEGRLRV 737

  Fly   482 NDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHS--KRHAYSVQLK-TRDRDCPHGLQ 543
            ||.:.|:|::|..:..::.|:..:.:.....:.::.|.|.|  .:...||.|. ...:||  |:.
Zfish   738 NDWLLKINDVDLANKDRQQVIKAVFSGGGGVINMLVRRRKSLGGKTVTSVHLNLAGQKDC--GVG 800

  Fly   544 LDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYV 608
            |:.|||::.:...|.|..:..:..|||:|:||..|:|            |.|.|:..||  |:..
Zfish   801 LESGVFVSSVSPGSPAAKDASVCPGDRILNINGISLD------------NKPLSECENL--LRSC 851

  Fly   609 QDQLPPGMTTSSAQTDSIDSMQHVSSAG--GGGGSGPSSATKHPSRF---AEFFFRKLKFS---- 664
            :|.:...:.....|:.|:.|:..:...|  ......|...::.||..   :....||..:|
Zfish   852 RDSVSISLLKFFPQSVSVQSISEIQRDGERNSNTDPPPRPSRKPSSISTSSSISIRKETYSPEHV 916

  Fly   665 -------------------KPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKE 710
                               .|.:|.||.:|                           |::.|.
Zfish   917 YRPEPYHQICLHPKRPLTFHPASPADNTQQ---------------------------RQRPTG-- 952

  Fly   711 KEASKSMGTWPR-----TNISHENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQ 770
                   ||||:     .|.|...|.          |:.:..:..|:::.|         .|:|:
Zfish   953 -------GTWPKIIPVAMNTSDSIPV----------AMATADSIPPLSIFK---------TPKKR 991

  Fly   771 PAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYP 835
            .:....|....|      :.|.:::.::     ||     :|..|......||.||....:..:
Zfish   992 KSIFDADVFKRP------ETLEYVKHTH-----TH-----SPQGSWTDTPAPPDPPKRSDSFKF- 1039

  Fly   836 THPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKT 900
               :|...|.:|.:                                               ...|
Zfish  1040 ---KHKTQGSSASD-----------------------------------------------STVT 1054

  Fly   901 SGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMP 965
            :|......|..:||..|...|.....|..|.      |:..|:......|.|   ..:.:.:.||
Zfish  1055 AGSPPATPVQESSSADADACVLQDGCVNNTD------PIELQRGRPKSAPAP---RRNLTPLKMP 1110

  Fly   966 LHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSES 1030
             :....||.....:|.|:|..             ||..|
Zfish  1111 -YTQSFSHDEQSPEPVDLVRF-------------SPFRS-------------------------- 1135

  Fly  1031 IGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATA-PH 1094
                                |||:..|..      |:..::|..|...|....:.:.|..|| .|
Zfish  1136 --------------------NRHSSAFTA------GHSLTAPRALSPYPAVTAVMRNPVYTAWSH 1174

  Fly  1095 -----DSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGH---------GLGIGPYMGVGGG 1145
                 :|..:|:        ||.|...|.   |.....:|..|         ..|.|.:     .
Zfish  1175 CVKTTNSASVPS--------HTYTQVSPQ---HQGRWSVDLNHKRSAELFDNSRGSGAH-----N 1223

  Fly  1146 VSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSAS 1210
            ...:..:..:|.:..|:   ||::|||.|..|   .|:..:..||:.|           ...|:.
Zfish  1224 THSLPSSARQGLSQYRE---QRIKIPSTPRYA---RSVHGSDRGSLSH-----------SDCSSP 1271

  Fly  1211 SSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMP------QVHVEVLSHG 1269
            |....|:|.|.|:.:.| |.:.|.|: |.|.:.|           ||:|      :..:...|..
Zfish  1272 SLVTPPLSPMDSASYTS-GQSQASGS-THSRLSV-----------SPVPIDRRRDRCVLRNRSFL 1323

  Fly  1270 GGGSGKRNSNVPADFLCP--GDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQ 1332
            .....:|:.......|.|  .:.|.|||.|..:.|||:|...:| ||||||.|.:.|.|.:..|:
Zfish  1324 KLSRSQRSWFASLRTLRPFIEEPRYVTIPKGAEPLGISIVGGDN-GGIFVSKVTEGSIAQKHHLE 1387

  Fly  1333 VGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGS 1397
            .||||||..|:|:|.||:::|..::.|..|:.|:|.|||..    ::..|          |||
Zfish  1388 FGDQLLEFNGVNLRNATEQLARLIIGQQCDTITILAQYNTH----MQQLG----------NHS-- 1436

  Fly  1398 PTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSA 1462
               |:|.|  ..:||        :..:.||:  |.:|.:|      |:|..|.:  .:...||..
Zfish  1437 ---RSSSR--MESSL--------SSHSTPGT--PDTHSNI------DTLSEQDE--GTMTPPSKQ 1478

  Fly  1463 ATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDV 1527
            ||       .||:.:.|..:|              |.|.|. ....:||:::.|||..|::|.|:
Zfish  1479 AT-------PTSSPHRERAEP--------------RQVLLR-KTPVDLGMRICGGNLTGVFVEDL 1521

  Fly  1528 AVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDS 1592
            ..|...   |::.||.|||.|.|.:...|||:...|:.|..:.:.:.|||:....::.||.|||.
Zfish  1522 EDGGAH---GLQPGDLILECNSVSMKSKTAEEVYLELLKPAENIVLRVQNRPQHFRRAKDTPGDG 1583

  Fly  1593 FYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQ-MKVE 1656
            ||||..||..|: :|.:|.|.||::||||:|:..|.||.|.||:||....:...|.:||: |..:
Zfish  1584 FYIRALFDHVGD-SEQELSFKKDDILYVDDTLPRGNFGYWLAWQLDENAQKLMRGHVPSKCMMDQ 1647

  Fly  1657 EELRSGEVVD--CDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIASFSNTQLSFFPDLGLLN 1718
            :..|...|.|  .::|:.:..|.:||||||||| |::||:|:|..:..:.........|.|
Zfish  1648 DSQRRYSVTDGKDESGSGKTLSAAARRSFFRRKLKHKRSTSKDGRDAPAADAISTDSMPYL---- 1708

  Fly  1719 DDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKE 1783
            :|..:.:||||..::|..||||||:|||.|.:...|..:....:..|....|...|:|:|.|:|:
Zfish  1709 EDCVSPAYQRVLKVESTNRRPVLILGPLVEPIKDMLLREAPGKYCRCLPEGMKAQQQAIERGVKD 1773

  Fly  1784 NIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIR 1848
            .:|:||:||...|:.|||.:|....:.| .||:||::..|:|||..:.|||||:.:|:::||||:
Zfish  1774 CLFIDYKRRSGHFDVTTVASIKEITEKD-CHCLLDIAPHAIERLHAVSIYPIVIFIRYRNAKQIK 1837

  Fly  1849 DIRD--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWV 1911
            :.:|  :..||:|.|.:||.:|.|.::|.||.:|.:.|:...::.:.||||...||:||:|:||:
Zfish  1838 EQKDPVYLRDKVSQKHSKEQFESAQRIEQDYSKYFTGVVQAGALSNTCTQIMAIVDQEQNKVLWI 1902

  Fly  1912 PVSS 1915
            |..|
Zfish  1903 PDGS 1906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	53/288 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	47/189 (25%)
		DUF1090	<326..408	CDD:284007	36/81 (44%)
		PDZ_signaling	439..516	CDD:238492	16/85 (19%)
		PDZ_signaling	533..592	CDD:238492	17/58 (29%)
		PDZ_signaling	1290..1369	CDD:238492	36/78 (46%)
		PDZ_signaling	1497..1576	CDD:238492	25/78 (32%)
		SH3_DLG5	1594..1657	CDD:212794	28/63 (44%)
		Guanylate_kin	1737..1904	CDD:279019	67/168 (40%)
		NK	<1773..1905	CDD:302627	54/133 (41%)
dlg5b.1	XP_021336124.1	Takusan	120..209	CDD:309799	8/27 (30%)
		APG6	232..>311	CDD:309295	17/91 (19%)
		SMC_N	<287..661	CDD:330553	97/392 (25%)
		PDZ_signaling	686..774	CDD:238492	17/96 (18%)
		PDZ_signaling	<797..857	CDD:238492	23/75 (31%)
		PDZ	1345..1426	CDD:214570	37/81 (46%)
		dbPDZ_assoc	1425..1486	CDD:318751	25/106 (24%)
		PDZ	1491..1567	CDD:214570	26/93 (28%)
		SH3_DLG5	1585..1647	CDD:212794	28/62 (45%)
		NK	1740..1896	CDD:327404	57/156 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595054
Domainoid	1	1.000	119	1.000	Domainoid score	I5746
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1450
OMA	1	1.010	-	-		QHG47148
OrthoDB	1	1.010	-	-		D123652at2759
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		otm25406
orthoMCL	1	0.900	-	-		OOG6_106741
Panther	1	1.100	-	-	O	PTHR46360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770