DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and cytip

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_003199223.2	Gene:	cytip / 100537036	ZFINID:	ZDB-GENE-140106-76	Length:	343	Species:	Danio rerio

Alignment Length:	319	Identity:	68/319 - (21%)
Similarity:	118/319 - (36%)	Gaps:	71/319 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 ILDDSNKRKLVC--GVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSR 518
            |:|.|.|::.:.  ..:.|||.    .:|....|...|....|::......:....|:..::|..
Zfish    22 IIDSSQKKRSILWRQRSFSSPK----NLNTEGMKGRTLSQSQLARTHSNSLVDYTDPQRTMVVLE 82

  Fly   519 TRHSKRHAYSVQ---LKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMD 580
            .:.::...:.||   ||.::..     .::|..|:.:::..|.| ....|..||.:||:|..|::
Zfish    83 KQDNEVFGFEVQTYGLKVKNTS-----MVEMCTFVCRVQDGSAA-ETAGLTAGDIILSVNGVSIE 141

  Fly   581 --SVQSIEEVMQ---------------------------LMNDPRSDGLNLFALKYVQDQLPPGM 616
              :.|:|.|:::                           |....|...:.|.:|...:.:|..|.
Zfish   142 GSTHQNIIELIRESSNTLKLETVSGSVMKRIELEKKMHYLKQTLREKWVELQSLTLKEKRLTQGN 206

  Fly   617 TTSSAQTDSIDSMQHVSSAGGGGG------SGPSSATKHPSRFAEFFFRKLKFSKPGTPEDN--- 672
            ...|||..|:||:..:||..|..|      |...|.....|....|.......|.|.:|.::
Zfish   207 LNESAQYLSVDSVMSLSSPMGRSGQRFSSDSSCRSIMTDDSEDGAFMSSVFDDSSPLSPIESSGS 271

  Fly   673 -FEQEHDDAIAALD--------SVLSENSS-----EKSKENLFNRKKRTKKEKEASKSM 717
             |:.|    :.||.        |:...|||     |.|..:||....|..::....|.:
Zfish   272 FFQLE----VGALRPITRTRSISLTGSNSSLSPGWETSPSSLFGTLPRRSRKGSVRKHL 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492	12/61 (20%)
		PDZ_signaling	533..592	CDD:238492	14/87 (16%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
cytip	XP_003199223.2	PDZ_signaling	78..162	CDD:238492	19/89 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900