DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and grip2

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_031757025.1 Gene:grip2 / 100495373 XenbaseID:XB-GENE-854056 Length:1115 Species:Xenopus tropicalis


Alignment Length:1428 Identity:238/1428 - (16%)
Similarity:426/1428 - (29%) Gaps:566/1428 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   316 SKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHERDKAIS 380
            :|.|..:|:...:...|..|:.:|.::          ..::..||....:.||           |
 Frog     5 NKVLRIVRRPSRRKKRESIRAEEDEDD----------DGDQESQEESCEEGLC-----------S 48

  Fly   381 DSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLE-VEL 444
            .||....|....|..||.|...:.|:                  |||...|..:.|..::| ::.
 Frog    49 LSLCVSDDGPYSKGNKDPAGNDLALV------------------SRRQSIPEEFRGVTIVELIKK 95

  Fly   445 SGYEHTSDLGIILD---DSNKRKLVCGVTSSSPAC--GKLKINDVICKVNNLDCQSLSKRMVLDE 504
            .|    |.||:.:.   |.:.:..|..:.|...|.  .:|.|.|.|..||.::...|....::..
 Frog    96 EG----STLGLTISGGTDKDGKPRVSNLRSGGLAARSDQLNIGDYIKSVNGINLTKLRHEEIISL 156

  Fly   505 IRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRD---CPHGLQLDMGVFIAKIEQNSLAFY----- 561
            ::....|.:|.|.         |.:...|.|..   .|..::    :.:.| |.||..|.     
 Frog   157 LKNVGERVVLEVE---------YELPPATPDNSSAIIPKTIE----ITLCK-EGNSFGFVMRGGA 207

  Fly   562 -----------------------EPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLF 603
                                   |..|.|.||:|.:                       ||::|.
 Frog   208 HEDWHKSRPLVVTYVRPGGPADREGTLKVSDRLLCV-----------------------DGISLH 249

  Fly   604 ALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGT 668
            .:.:               ||::..::..|.                                  
 Frog   250 NITH---------------TDALSILRQCSQ---------------------------------- 265

  Fly   669 PEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGT 733
             |..|:.|:|  :|.:|:|.:.:.               ....|.:|:.|:....::|    |||
 Frog   266 -EAVFQIEYD--VALMDTVTNASG---------------PLLVEIAKTPGSTLGISLS----TGT 308

  Fly   734 MRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSN 798
            .|..:            .|.:||            .:||::: |:.....|..      ||...:
 Frog   309 HRNKQ------------VIVIDK------------VKPASVV-DRCGALHPGD------HILSID 342

  Fly   799 GGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGA 863
            |.:.:......:..:.:.:           :.|......|.|.      ..::.:|.:...:..:
 Frog   343 GTSTEHCTLMEATQLLASI-----------IENVKLEILPAHH------SRLSLRPPETVKVQKS 390

  Fly   864 NARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVG 928
            :..........|...||..|..    ||:.:    .||.|:..:.::.|:.:|        |.|.
 Frog   391 DHHHCWDPCVNYCHTPHPGHCK----TPTWN----STSNQEYCKSLVAANFSS--------SSVA 439

  Fly   929 GTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQ--NS 991
            ||                       |..||.::..:|    |.:||.   .|...:|.:.|  ..
 Frog   440 GT-----------------------PGFSSQNSNTLP----RTAHPM---SPRTTMSRRRQKRKD 474

  Fly   992 IESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHG----GYGGFLQSNHMPGNR 1052
            .:|.||..|..:...|.         :.|       :||....:.|    |:|..||..      
 Frog   475 HKSSLSLASSTVGPGGQ---------IIH-------TESTEIILRGDPLNGFGIQLQGG------ 517

  Fly  1053 HTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMP 1117
               :|.|             .||.|||    |.:.....:|.:..|:                  
 Frog   518 ---IFAT-------------ETLSSPP----LIRFIEPDSPAERCGL------------------ 544

  Fly  1118 HPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSS 1182
                                  :.||..:..:.|.:.|.||.  ::.||.||      .|:.|:.
 Frog   545 ----------------------LQVGDRLLSINGILTEDGTL--EEANQLLR------DAALSNK 579

  Fly  1183 MVKNSSGSIDHHYVTSTG------PVSGG---SMSASSSDRAP-MSLMSSSIHNSYGANIAGGNG 1237
            :.......:....|.|:|      |...|   .::.||:.|.| ..|:.|.|.....|:..|...
 Frog   580 VALEIEFDVAESVVPSSGTFHVKLPKRKGVELGITISSASRKPGEPLIISDIKKGSVAHRTGTLE 644

  Fly  1238 TGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTI------- 1295
            .|..:             ..:..:.::..|........|...         ||.::.|       
 Frog   645 PGDKL-------------LAIDNIRLDNCSMEDAVQILRQCE---------DLVKLKIRKDEDNS 687

  Fly  1296 DKRDKSLGI--TIQCNNNGG--------------GIFVSTVADKSTAMRAG-LQVGDQLLEVCGI 1343
            |:::.|..|  |::....||              .|.:|.:..:..|.|.| :.:||::|.:..:
 Frog   688 DEQETSGAIIYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHIGDRILAINNV 752

  Fly  1344 NMRAATQEIAANVLRQCGDSFTMLVQYN-----PEKFPSIEYEGAHNLEPESPINHSGSPTPRN- 1402
            :::......|.::|:..|::.|:.::..     |::......||:   :||..:..|...:..: 
 Frog   753 SLKGKPLSEAIHLLQMAGETVTLKIKKQAERIFPQRLSDSMNEGS---DPEDDLTDSQKTSKLSD 814

  Fly  1403 --SPRPPARNSLFPL--------------PMQPQA-----------PSTRPGSRAPLSHQSIKDQ 1440
              |...|:.:|....              ...|||           .|.:..|..|:.|:  |..
 Frog   815 IYSTAVPSVDSALESWDGSGIDAGYGSQGTYVPQAVGISLHPHEWRTSRQKSSTPPVEHR--KSY 877

  Fly  1441 SFTDSLENQSD------------------------------------------------------ 1451
            .|.|...|:.|                                                      
 Frog   878 PFLDGSFNEQDWEKPTRYPSQPNGLEADHDDSFWRVFGEALEDLETCGQSELLREIEASIMTGSV 942

  Fly  1452 ----ISSSQ-----------------------DMPSSAATTTTTTASATSTVYDEEPKPSLPPPP 1489
                :.|||                       :.|......:....:....|:|.:         
 Frog   943 QGLGLDSSQILLENSNQGGHVLFRKGSHPISSNSPKKENKLSQEARTKKEEVHDAQ--------- 998

  Fly  1490 ASVPAETLRYVTLHMD-KSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGV 1550
             |:..|.|: ||:..| .:.:.|..:..| .:.|:||:.:..|.|:|.:|::..|:||:.|.|
 Frog   999 -SLSTELLK-VTVQKDMDTDDFGFSVSDGLLEKGVYVNMIRPGGPADRSGLKTYDRILQVNHV 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 3/16 (19%)
CENP-F_leu_zip 229..360 CDD:287450 6/43 (14%)
DUF1090 <326..408 CDD:284007 16/81 (20%)
PDZ_signaling 439..516 CDD:238492 18/82 (22%)
PDZ_signaling 533..592 CDD:238492 14/89 (16%)
PDZ_signaling 1290..1369 CDD:238492 20/102 (20%)
PDZ_signaling 1497..1576 CDD:238492 18/56 (32%)
SH3_DLG5 1594..1657 CDD:212794
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
grip2XP_031757025.1 PDZ_signaling 87..169 CDD:238492 18/85 (21%)
PDZ_signaling 187..272 CDD:238492 19/162 (12%)
PDZ_signaling 287..370 CDD:238492 19/128 (15%)
PDZ_signaling 499..585 CDD:238492 27/159 (17%)
PDZ_signaling 598..681 CDD:238492 16/104 (15%)
PDZ_signaling 697..778 CDD:238492 15/80 (19%)
PDZ_signaling 1007..1084 CDD:238492 17/53 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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