DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and whrn

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_012824768.2	Gene:	whrn / 100486736	XenbaseID:	XB-GENE-989669	Length:	996	Species:	Xenopus tropicalis

Alignment Length:	961	Identity:	198/961 - (20%)
Similarity:	300/961 - (31%)	Gaps:	338/961 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 VSRTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMD 580
            :.|.|:.:...:|::         .|::...|::::.:|..|||..| .|.|||::|..|.:.:|
Frog   236 LKRNRNQEGLGFSIR---------GGVEHGTGIYVSLVEPGSLAEQE-GLRVGDQILKANGRPLD 290

  Fly   581 SVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSS 645
            .|...|.|..|..   |..|.|..|.  ..::|.|..:|...| .:|:  |      |....|..
Frog   291 RVTHAEAVKALRG---SQKLVLSVLS--SGRIPGGHISSHIYT-WVDA--H------GRSVSPPR 341

  Fly   646 ATKHPSRFAEFFFRKLKFSKP---GTPED-----NFEQEHDDAIAALDSVLSENSSEKSKENLFN 702
            ...|             ...|   ||.::     ...||.|:  ..::.||.|.||    ..|..
Frog   342 GPPH-------------LQSPLLAGTEQEKRSHLQLLQEGDE--KKVNLVLGEGSS----LGLLI 387

  Fly   703 RKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRA-------LMSLFTAGPINVDKDD-- 758
            |       ..|..|:|.:         .||..:|:|.:.|       ::.:..:..:::..|:
Frog   388 R-------GGAEYSLGIY---------ITGVDKGSEAESAGLKVGDQILDINGSSFLSIPHDEAV 436

  Fly   759 ELMG----------EVG-VPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNP 812
            .::|          :|| :|.   |..|.|:         ::.|......||....:....:...
Frog   437 RILGSSRHLMMTVRDVGRIPH---ARTIVDE---------TQWLTSSYTGNGEPQPSLGTLSDTS 489

  Fly   813 VSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQER--- 874
            ..|.|..:|..||....               ||...:..   |...|:...||:.:...||
Frog   490 SDSLVKPVFCRGPTGSQ---------------VTLSSLGN---QTLVLLEEKARLLLTEPERSTM 536

  Fly   875 -YGTRPHSNHRLSL-----------------------------NITP------------------ 891
             |..:.:.:|.:|:                             .|.|
Frog   537 SYYLQQYKDHHISVQALIMAMFELLNTQAKVTATFSLLSELRSQILPQDLAVFDNLVLKREIESM 601

  Fly   892 -----SGDFYQP-----KTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYD 946
                 |||....     .||..::.|.|..||:...                      |...:.|
Frog   602 KSRQRSGDTVSVLSQTLSTSSSESHQTVSTASTARE----------------------RLLWLLD 644

  Fly   947 VFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAK 1011
            |......|:.||.|...     |:.:.|.        :||...||:........||
Frog   645 VMENGTDPEGSSDSRSL-----TQTTLPD--------ISLDDVNSLLEEPPNFQPA--------- 687

  Fly  1012 RHVPQ-AVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTL 1075
              .|| ||::.|:.                      ...|....|. |:.|....|...:.|.|.
Frog   688 --PPQSAVQNAPQL----------------------RRQGRERAQR-PSSGSSQSGLFFTVPSTN 727

  Fly  1076 PSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHP--------HPHAPYLDYGH 1132
            ||||       ||..|:|..|............:|:.....|...|        ||..|
Frog   728 PSPP-------LPPLTSPPASPSSENSSQAIYTNHSSKITSPSLPPAQLALVTQHPLTP------ 779

  Fly  1133 GLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLR----IPSNPSVASKSSSMVKNSSG--SI 1191
                                      |||.:...||:    |||:|...:...:...||..  .:
Frog   780 --------------------------FPRVQSPTRLKVLGEIPSHPPSTTNGEASDNNSQHFVMV 818

  Fly  1192 DHHYVTSTGPVSGGSMSASSSDRA------PMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGG 1250
            :.|...|...|:  .:.|....||      |.||  |.:.:| |..::..:|    :..|..|||
Frog   819 EVHRPNSEPDVN--EIRAVPQTRAVLPLSPPASL--SQLSDS-GQTLSEDSG----VDAGDVGGG 874

  Fly  1251 GSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGI 1315
            ||...||.||     .:.|..|..|     |...|.| ....|.:.|...||||.|:    ||..
Frog   875 GSKDSSPQPQ-----KTKGCEGLQK-----PPGLLEP-TATLVRVKKTAPSLGIAIE----GGAK 924

  Fly  1316 FVSTVADKSTAMRAG-------LQVGDQLLEVCGINMRAATQEIAANVLRQ 1359
            ....:....|..|.|       |:||..:|||.||:|:......||.::.:
Frog   925 TRQPLPRIVTIQRGGSAHNCSKLKVGQVILEVNGISMQGKEHREAARIIAE 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492	198/961 (21%)
		PDZ_signaling	533..592	CDD:238492	17/58 (29%)
		PDZ_signaling	1290..1369	CDD:238492	23/77 (30%)
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
whrn	XP_012824768.2	harmonin_N_like	40..117	CDD:416392
		PLN02983	<144..>217	CDD:215533
		PDZ_signaling	231..312	CDD:238492	24/88 (27%)
		PDZ_signaling	370..450	CDD:238492	17/101 (17%)
		HN_L-whirlin_R2_like	513..597	CDD:259823	11/86 (13%)
		PDZ_signaling	905..976	CDD:238492	23/75 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910