DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and whrna

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	984	Identity:	213/984 - (21%)
Similarity:	328/984 - (33%)	Gaps:	270/984 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 SCSEKLAELKKERNMVA--VEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNVLSLTE 236
            |.|..:.:|....|::.  :|||::..........||.|    |..|.|||:|:..||.  .|..
Zfish    24 SLSANVKKLHNALNLLLSDLEREQFIHCLNVYHSKRNVY----DLVQTLKVILNVPSKR--QLLP 82

  Fly   237 ELNQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLAR--AEIKVLQLANADLKKRDLLKSR 299
            .|..::...|.:|.: |..|:.|.| ..||.....|...|:  |.......||....:..|..|.
Zfish    83 MLRLVIPRSDQLLFD-QYTSEGLYL-KSEIHARNGDPDGAQEGANSSPTHGANFPASQVALRGSP 145

  Fly   300 DS-SWSKE---------------FPSGK----ELENSKELEKLRKSLEKA--------LSEVERS 336
            || |.|.:               .|.|:    .|:..|..|.|..|:...        :|.||..
Zfish   146 DSISTSSDGTATLIPLLGRNFLPEPPGEIRQVILKRHKSNEGLGFSIRGGSEHGVGIYVSLVEPG 210

  Fly   337 SQDAEEAKRVRDWAISQREKI---VQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKI------ 392
            |...:|..|:.|..:...:|:   |...|:||.|         |......|::|...:|
Zfish   211 SLAEKEGLRMGDQIMKVNDKVFDRVTHADAVKVL---------KGSKKLCMSVRSVGRIPGGYIT 266

  Fly   393 -------KKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHT 450
                   ..|........|||.|......|:   ||:.|  ||......:|::
Zfish   267 NHVYTWVDPQGRSVSPPPDLLAEHRSATLRR---SNSQG--RSHMQLLQDGDE------------ 314

  Fly   451 SDLGIILDDSNKRKL-------------VCGVTSSSPA-CGKLKINDVICKVNNLDCQSLSKRMV 501
            ..:.::|||.....|             :.||...|.| ||.:|:.|.|.:||.....|:..
Zfish   315 KKVNLVLDDGRSLGLMIRGGAEYSLGIYITGVDRGSAAECGGIKVGDQILEVNGRSFLSIPH--- 376

  Fly   502 LDE-IRACAPRSLLL-----VSRTRHSK------RHAYSVQLKTRDRDCP-HGLQLDMGVFIAKI 553
             || :|.......|:     |.|..|::      :...|.|:........ .|:.||.|...:.
Zfish   377 -DEAVRVLKSSHHLMMTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSVTGISLDQGASTSA- 439

  Fly   554 EQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQ-----DQL- 612
               ...||:........:.|:.|:|...::  |:...|:.:|....:..:..:|..     :||
Zfish   440 ---KGGFYKGVAGSQVTLSSLVNQSRAMLE--EQARHLLTEPERQTMGYYIQEYRDGHVGVEQLV 499

  Fly   613 ------------------PPGMTTSS-----------AQTDSIDSMQHVSSAGGGGGSGPS-SAT 647
                              ..|:.|..           .:.|::.:.|     |||.|...| |..
Zfish   500 MALFELFNTHAKFSLLSEVRGIVTPQDVEKFDGLVLRREIDALKARQ-----GGGAGFQDSFSMV 559

  Fly   648 KHPSRFAE---FFFRKLKFS---KPGTPEDNFEQ---EHDDAI--AALDSVLSENSSEKS----- 696
            .:|...|.   .|......|   ..|..|:|.||   ||.:|:  .:||.|.|.:.|..|
Zfish   560 SYPDTLASSSASFMTNTTLSSARNDGVAENNGEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPP 624

  Fly   697 KENLFNRKKR----TKKEKEASKSMG---TWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINV 754
            ...|..|..|    :|:...:|...|   |.|..:.:.|:     :..:..:|.||  ..|.:.:
Zfish   625 PPGLQRRPSRKATLSKRPSSSSSQSGLYFTAPSRSHTRES-----KHPKAPKAFMS--PPGTLKI 682

  Fly   755 DKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPV---SSG 816
            |          ||..|.:.:.|..:.|  .|::..|           .|..|.::|:|:   :..
Zfish   683 D----------VPASQLSVVSQHPIGP--FPRVQSP-----------NKAKPAQSSSPIPPPAPN 724

  Fly   817 VSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHS 881
            |.|  |||||...|    |..|..|        ...||...:|  .:|....|....|....|..
Zfish   725 VPA--PPGPPPPPP----PPLPPPS--------CPDKPTPSSP--ASNQHFVMVEVHRPNAEPDV 773

  Fly   882 NHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGV-GSGSMVGGTGPAAGEFPVRKQQVY 945
            |....|.....|...|...|||        ..|..:|..: .||.:...|.|.    |.|.:
Zfish   774 NEVRPLPQVRGGTLSQLSDSGQ--------TLSEDSGVDIPESGRLSKDTSPR----PARTR--- 823

  Fly   946 DVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAIS-EYGMY 1009
                   .|::..|..       ...:.||.:.:|...:       :....||.:..|: |.|..
Zfish   824 -------APRDGHGGG-------ETSAKPPGLLEPMSTL-------VRVAKSASTLGIAIEGGAN 867

  Fly  1010 AKRHVPQAV 1018
            .::.:|:.|
Zfish   868 TRQPLPRIV 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	47/190 (25%)
		CENP-F_leu_zip	229..360	CDD:287450	38/163 (23%)
		DUF1090	<326..408	CDD:284007	21/105 (20%)
		PDZ_signaling	439..516	CDD:238492	20/96 (21%)
		PDZ_signaling	533..592	CDD:238492	10/59 (17%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822	22/83 (27%)
		PDZ_signaling	174..255	CDD:238492	20/89 (22%)
		PDZ_signaling	314..394	CDD:238492	20/95 (21%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	10/80 (13%)
		PDZ_signaling	848..919	CDD:238492	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810