DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and magi3

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_012811019.1 Gene:magi3 / 100036692 XenbaseID:XB-GENE-981179 Length:1595 Species:Xenopus tropicalis


Alignment Length:1639 Identity:305/1639 - (18%)
Similarity:496/1639 - (30%) Gaps:612/1639 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   439 LLEVELSGYEHTS--DLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMV 501
            |||:. .|.||..  .||     ..:..:...:....|:.|     ||:.:||......|:.|..
 Frog    30 LLEIR-GGAEHGEFPYLG-----RQREDVASFIVGKVPSQG-----DVLLEVNGTPVSGLTHRDT 83

  Fly   502 LDEIRACAPRSLLLVSRTRHSK------RHAYSVQLKTRDRDCPHGLQ--LDMGVFIAKIEQNSL 558
            |..||..  |..:.:...:..|      ||..|:|.:....|  |.||  :...:::..|...:.
 Frog    84 LAVIRHF--REPIRLKTVKPGKVINKDLRHYLSLQFQKGSID--HKLQQVIRDNLYLRTIPCTTR 144

  Fly   559 AFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDG-----------LNLFALKYVQDQL 612
            :..:.|:...|    .|..|::..:::|:...|:.....||           .|.|....|...|
 Frog   145 SPRDGEVPGVD----YNFISVEQFKALEDSGVLLESGTYDGNFYGTPKPPAEPNPFQADPVDQVL 205

  Fly   613 PPG---MTTSSAQTDSIDSMQHVSSA-------------GGGGGSGPSSATKHPSRFAEFF---- 657
            ..|   ..|...:|.|:..||...|:             .|..||......:.||.:.:..    
 Frog   206 FDGEFDTETQRKRTTSVSKMQRTDSSLPEEEDEEEREAVNGSSGSTDHRDRQEPSEWGKTVPSYN 270

  Fly   658 --FRKLKFSKPGTPEDNFEQ------------------EHDDAIAA-LDSVLSENSS-------- 693
              ...:.|....|.::|.|.                  :|:..... ||..|.:.:.        
 Frog   271 QTNSSMDFRNYLTRDENLEPLPKNWEMAYTEAGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDG 335

  Fly   694 ------EKSKENLF--------NRKKRTKK---EKEASKSMGTWPRTNISHENPTGT-------- 733
                  ||.::..:        |:|.:...   |.:..|.:...|.....|:.|..:        
 Frog   336 ELPYGWEKIEDPQYGTYYVDHINQKTQFDNPVLEAKRKKQLNPAPSEGTVHQEPENSQFTRDPSQ 400

  Fly   734 MRG-----NEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAA---------LIQD------- 777
            ::|     :.||.|:...||.  |..|:.||.:....|.:..|||         :|.|       
 Frog   401 LKGALLHTSLKKSAMGFGFTI--IGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGTCVL 463

  Fly   778 -----------QLPP-------------PLPPQMSKPLAHIRGSNGGAIKTHP------------ 806
                       ||.|             |||.....|:|.|       :.|.|            
 Frog   464 GHTHAEVVQMFQLIPINQYVNMTLCRGYPLPEDSDDPVADI-------VNTVPPIINGQMLTQGD 521

  Fly   807 -NRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMP 870
             |..|..:.|||..|...|.|.                                ||..|.|:..|
 Frog   522 INMGSQELKSGVIDLDQRGKPG--------------------------------LMVVNGRLNGP 554

  Fly   871 SQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVG--GTGPA 933
                           ||:|              |.|:..|.:|..|....|....:.|  |.|.|
 Frog   555 ---------------SLDI--------------QDQRTSMASSGNSLPELVTIPLLKGPKGFGFA 590

  Fly   934 AGEFPV--RKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESI- 995
            ..:.|:  :.:.:.|....|.|.|.                         ||:......::::: 
 Frog   591 IADSPMGQKVKMILDSQWCPGLQKG-------------------------DVIKEICHQNVQNLT 630

  Fly   996 ------LSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHT 1054
                  :..:.|..:|..:...|..|.:...|.|..||.:.:...:.                  
 Frog   631 HIQVVEVLKQFPVGAEVPLLILRGGPPSPSKVTKVKSDKQELMGSIE------------------ 677

  Fly  1055 QLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHP 1119
                ...||     ...|..||.||      .|..:.:|        .||....:....|.. ..
 Frog   678 ----AIAPG-----EPLPQPLPFPP------NLARSCSP--------KLDPSEVYKKSKNIF-ED 718

  Fly  1120 HPHPHAPYLDY-------GHGLGIGPYMGVGGGVSGVGGAIYEGGTFP---RKKDNQRLRIPSNP 1174
            .| |:...||.       |.|..:     :||  .|...|||.|...|   .:||. |||     
 Frog   719 KP-PNTKDLDVFLRKQESGFGFRV-----LGG--DGPDQAIYIGAIIPLGAAEKDG-RLR----- 769

  Fly  1175 SVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNS----------YG 1229
                           :.|........||.|      .|.:..:.||:::..|.          |.
 Frog   770 ---------------AADELICIDGVPVKG------KSHKQVLDLMTNAARNGHVLLTVRRQIYY 813

  Fly  1230 ANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSH---GGGGSGKRN----SNVPADFLCP 1287
            .:                           .|...|.|.|   ...||.:.|    |.:|.   .|
 Frog   814 TD---------------------------KQQEEEELQHTPPAHNGSPRLNRIEVSAIPK---LP 848

  Fly  1288 GDLRRVTIDKRD-KSLGITIQCNNN--GGGIF---VSTVADKSTAMRA-GLQVGDQLLEVCGINM 1345
            .:...|.:.::| :..|..|..:.|  ..|:.   :..|.:.|.|.|. .|:|||::..|.|.::
 Frog   849 AEAYDVILQRKDNEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCRKLKVGDRISAVNGQSI 913

  Fly  1346 RAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARN 1410
            ...:.:....:::..|::.|:.|....|                    |.|.|:..||.|     
 Frog   914 VELSHDNIVQLIKDAGNTVTLTVIAEEE--------------------HRGPPSGSNSAR----- 953

  Fly  1411 SLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATST 1475
                   |..||..||..:...::.::...|::|   :::|..                      
 Frog   954 -------QSPAPQHRPMGQTQPTYGTLDRYSWSD---HKADCG---------------------- 986

  Fly  1476 VYDEEPKPSLPPPPASVPAETLRYVTLHMDKS-KNLGIKLFGGNK--VGIYVHDVAVGSPSDHAG 1537
                   |:|  |..|..|:::....:.:::. :..|..|.||.:  :|:::..:|...|:...|
 Frog   987 -------PAL--PAGSWQAQSVGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDG 1042

  Fly  1538 -IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDR 1601
             |..||||:|.|.....|:|..:|...|......|.:|::            ||           
 Frog  1043 RIHVGDQIVEINNEPTQGITHTRAIELIQAGGSKVLLLLR------------PG----------- 1084

  Fly  1602 TG---ELNE-DDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSG 1662
            ||   :.|| |........|::.|.|.|:.|........:..:.:..| |.:        |:...
 Frog  1085 TGLIPDYNELDSAHPSSTSVVFEDLTTFSSTSFTTPVPGVSCLKNYDE-GFV--------EVPEK 1140

  Fly  1663 EVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQ 1727
            ::|                     .|:....||:.|.:.||| ||            |....|:|
 Frog  1141 DIV---------------------PKDNIQKSRNVTSLPSFS-TQ------------DQEMESFQ 1171

  Fly  1728 RVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAME--EGLKENIFVDYR 1790
            :    |:|:.                   ||.|..|..:.:....:..:|.  |..|||    .:
 Frog  1172 Q----DNPVS-------------------DFLNNSKTKDASVSPRNTISMNQLEAAKEN----GK 1209

  Fly  1791 RRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGT 1855
            |||.     :|....:..||...|         ::.||..:.|         .:|:||| |....
 Frog  1210 RRGR-----SVSPKKSINKNSSSH---------LDGLQEHREY---------VSKEIRD-RSTSP 1250

  Fly  1856 DKISAKAAKEMYER 1869
            .|:..|..:.:.::
 Frog  1251 RKVHTKTTEGVADK 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492 20/78 (26%)
PDZ_signaling 533..592 CDD:238492 10/60 (17%)
PDZ_signaling 1290..1369 CDD:238492 18/85 (21%)
PDZ_signaling 1497..1576 CDD:238492 21/82 (26%)
SH3_DLG5 1594..1657 CDD:212794 12/66 (18%)
Guanylate_kin 1737..1904 CDD:279019 26/135 (19%)
NK <1773..1905 CDD:302627 22/99 (22%)
magi3XP_012811019.1 PDZ_signaling 31..97 CDD:238492 19/78 (24%)
NK 119..>193 CDD:388413 13/79 (16%)
WW 290..322 CDD:197736 3/31 (10%)
WW 337..368 CDD:197736 4/30 (13%)
PDZ 410..490 CDD:214570 18/81 (22%)
PDZ 574..655 CDD:214570 15/105 (14%)
PDZ_signaling 727..808 CDD:238492 24/114 (21%)
PDZ_signaling 852..937 CDD:238492 18/84 (21%)
PDZ_signaling 1004..1082 CDD:238492 21/77 (27%)
PTZ00121 <1202..1571 CDD:173412 21/91 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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