Protein Alignment Cog8 and Cog8

DIOPT Version :10

• Sequence 1: NP_609503.2
• Gene: Cog8 / 34571
• FlyBaseID: FBgn0287204
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_631975.3
• Gene: Cog8 / 97484
• MGIID: 2142885
• Length: 640
• Species: Mus musculus
• Alignment Length: 601
• Identity: 256/601 - (42%)
• Similarity: 358/601 - (59%)
• Gaps: 45/601 - (7%)

  Fly     8 DLENERVLKLIFPDGVPD-NLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAI 71
            ::|:|.:|..:|.|..|: ..|..|::..||.:|....:::|::|..|||||....|:||:|||.
Mouse    26 EVEDEGLLASLFRDRFPEAQWREKPDVGRYLRELSGSGLDRLRREPERLAEERAQRLQQTRDLAF 90

  Fly    72 SNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKN 136
            :||:|||..||.:..|...|...|..|..|:.:||.....|..|::::.|::..||:|::||.::
Mouse    91 ANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPRFQQSCRNFVKEAEEISSSRRMNTLTLNRH 155

  Fly   137 AQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVA 201
            .::||:||:||||:.|:|...:|||||||||..||.:....|||:..||..|......||.||:.
Mouse   156 TEILEILEIPQLMDTCVRNSYHEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQ 220

  Fly   202 QLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITR 266
            ||||::|||.||:::||||||..|.:.|||:||||||||||.|.|.|||..|...|::||||..|
Mouse   221 QLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEACR 285

  Fly   267 INLFNIITQYRAIFPEDEGTLKTQSSLRPLQG-VSCNGDRLFQAWLHNKISDFLQTLERDLQLGV 330
            ::||:||||||||| .||..|     |.|..| .:.|...:|..|:..|||.|||.||.||..|:
Mouse   286 VHLFDIITQYRAIF-SDEDPL-----LPPAMGEYTVNEGAIFHGWVLQKISQFLQVLETDLYRGI 344

  Fly   331 GS-VETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKV 394
            |. ::::|||||||||||||||||||..:||:|..|....|:.:||:..|:|:.|:..:|||:..
Mouse   345 GGRLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAISTFQKAVEEAVEKFQDEMTSYTLISTA 409

  Fly   395 AL--HSHARKQVDPEQE-SYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHS 456
            |:  .|:....|...|. :..||..||||.|||...|..|.|.|:||||.|:|||.|||..|:::
Mouse   410 AILGSSNTPATVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGTLENA 474

  Fly   457 LQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGISLLQ 521
            |.:..:.:|||:|.|:..|:..|.|.||:.|:....|||||:.||:..:|||..:...||||..|
Mouse   475 LTKVTKTILAFHRAEEAVFSSGEHEIFVQFCTAFLEDLVPYLNRCLQVLFPPAQIAQTLGISPTQ 539

  Fly   522 LEQQ-QLTYLQQTRILEPLKHLLPTKA-------------LVQP------QDKVME--------- 557
            |.:. .|.::..:.|.|||..:||.:.             ||.|      :.:.||
Mouse   540 LSKHGNLGHVNISAIQEPLAFILPKRETVFCLDEQELGPDLVAPAPELPAEQRSMEPVTEKREPG 604

  Fly   558 ----AKPSAGVPVTAE 569
                .:|..|.|:.||
Mouse   605 EPLPQEPMEGEPLPAE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..355	CDD:427729	158/319 (50%)
Cog8	NP_631975.3	Dor1	56..370	CDD:427729	154/315 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	580..640		4/8 (50%)