Protein Alignment Cog8 and COG8

DIOPT Version :9

• Sequence 1: NP_609503.2
• Gene: Cog8 / 34571
• FlyBaseID: FBgn0287204
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_013640.1
• Gene: COG8 / 854904
• SGDID: S000004536
• Length: 607
• Species: Saccharomyces cerevisiae
• Alignment Length: 610
• Identity: 123/610 - (20%)
• Similarity: 213/610 - (34%)
• Gaps: 210/610 - (34%)

  Fly     8 DLENERVLKLIFPDGVPDNLRGN-PELDNYLAKLG-----TCKVEQLKKEQTRLAEEAR-TILEQ 65
            ||..|:  |.:..|.:.|.|:.| .:.::|.:...     |..:.::..|.:.|..:.| |:|:.
Yeast    12 DLTEEQ--KRLSLDFLQDILQSNTKDYESYFSSRAVPGSITEDIAEIDAELSALDRKIRKTLLDN 74

  Fly    66 TQDLAISNYRTFITTAEN-SRSIFSEFLRSEQQ---LDTLVSKLPDL----------SVQCERFL 116
            |..: |.|      ..|| .|:...:..:|.:|   |||.::|..|.          ||..:.||
Yeast    75 TSQI-IGN------ILENDDRAQLDDIAKSLEQLWELDTNINKAADRNVTNDDINNESVSIDDFL 132

  Fly   117 QDSAELNEQRRLNS-----------------------------------------ITLQKNA-QL 139
            :|..|.|:..|:.:                                         :|:.:|. .:
Yeast   133 EDDKEDNDTGRIMTTESNNLARKKKEDEFHKALSRLRNRISTKEDDKDDIRSDTLVTVLENLDSI 197

  Fly   140 LEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSV-EALWHNMLVQLVAQL 203
            .:::|||.|...|||.|.|:||:.|..:.|.|........:|..:...| ..:...||..||..|
Yeast   198 TDLMELPFLARTCIRTGHYQEAVMLYTHTTSLRSRFPGSTIVDEVCEKVLNEISTTMLSGLVKLL 262

  Fly   204 RTDLQLPKCLQIVGYLRRMQAFG---DNELRLKFLQARDAWLTSCLEAIPTADAQQH-------- 257
            .|::.:....:|:.||..:..|.   :..|...||..|..::|..:.:.| .|.:..
Yeast   263 STNVSVNSLKKILQYLNSIPPFDGKTNKSLLSVFLAMRYKFITDEIASYP-LDVESSNESLIEMM 326

  Fly   258 LSKTIEITRINLFNIITQYRAIFPEDEGTL------KTQSSLRPLQGVSCNGDRLF--------- 307
            :.:.||:.|.:::..:..:...|..|...|      :.:|::..:.|.  |.::..
Yeast   327 VKRKIEVLREHVYMSLNVFLKSFLYDTNDLEIPFPEELESTVLRINGT--NEEKEIEEKEKETKK 389

  Fly   308 -----QAWLHNKISDF-----LQTLERDLQLGVGSVETVLGQCMYFGLSFSRVGADFRALMAPIF 362
                 |..:.|...|.     ::.::.::|   |.||                |.|..|
Yeast   390 EEYQKQDSVANNEEDVTENKSIEDVQEEVQ---GKVE----------------GEDDGA------ 429

  Fly   363 VGVIRRRFESSVEQ--------------------VDEQFERELERFTLINKV---------ALHS 398
                .|:.|:.:|.                    .|.:.|:|.|.   ||||         ::.:
Yeast   430 ----ERKTENEIENETVNKTEDKAEKEKEEEVNTKDNKAEKEEEE---INKVEVTPEEPSKSIDN 487

  Fly   399 HARK--------QVDPEQ----------ESYAPPEA-LLDF------YPLAALCNGYLSALNELR 438
            .|.|        :|.||:          |:..|..| :|.|      |.|..|..|    ||.::
Yeast   488 KAEKEEEEINKVEVTPEEPSKKIRTSKRENKIPTNAVMLQFVDKCITYVLKDLTRG----LNSIK 548

  Fly   439 L----CAPLALAT----DVTRCLQH 455
            |    |..|...:    |:.|...|
Yeast   549 LSDSVCLQLVYCSFRLCDLNRNYHH 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..379	CDD:252394	84/460 (18%)
COG8	NP_013640.1	Dor1	28..375	CDD:252394	73/356 (21%)
		PTZ00341	<244..517	CDD:173534	53/307 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2069
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21311
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4192
TreeFam	0	0.000	Not matched by this tool.
	5	4.930