Protein Alignment Cog8 and COG8

DIOPT Version :10

• Sequence 1: NP_609503.2
• Gene: Cog8 / 34571
• FlyBaseID: FBgn0287204
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_001366190.1
• Gene: COG8 / 84342
• HGNCID: 18623
• Length: 659
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 251/613 - (40%)
• Similarity: 356/613 - (58%)
• Gaps: 61/613 - (9%)

  Fly     8 DLENERVLKLIFPDGVPD-NLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAI 71
            ::|:|.:|..:|.|..|: ..|..|::..||.:|....:|:|::|..|||||...:|:||:|||.
Human    20 EVEDEGLLASLFRDRFPEAQWRERPDVGRYLRELSGSGLERLRREPERLAEERAQLLQQTRDLAF 84

  Fly    72 SNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKN 136
            :||:|||..||.:..|...|...|..|..|:.:||.....|..|::::.|::..||:||:||.::
Human    85 ANYKTFIRGAECTERIHRLFGDVEASLGRLLDRLPSFQQSCRNFVKEAEEISSNRRMNSLTLNRH 149

  Fly   137 AQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVA 201
            .::||:||:||||:.|:|...||||||||||..||.:....|||:..||..|......||.||:.
Human   150 TEILEILEIPQLMDTCVRNSYYEEALELAAYVRRLERKYSSIPVIQGIVNEVRQSMQLMLSQLIQ 214

  Fly   202 QLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITR 266
            ||||::|||.||:::||||||..|.:.|||:||||||||||.|.|.|||..|...|::||||.:|
Human   215 QLRTNIQLPACLRVIGYLRRMDVFTEAELRVKFLQARDAWLRSILTAIPNDDPYFHITKTIEASR 279

  Fly   267 INLFNIITQYRAIFPEDEGTLKTQSSLRPLQGV-SCNGDRLFQAWLHNKISDFLQTLERDLQLGV 330
            ::||:||||||||| .||..|     |.|..|. :.|...:|..|:..|:|.|||.||.||..|:
Human   280 VHLFDIITQYRAIF-SDEDPL-----LPPAMGEHTVNESAIFHGWVLQKVSQFLQVLETDLYRGI 338

  Fly   331 GS-VETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKV 394
            |. ::::|||||||||||||||||||..:||:|..|....|:.::::..|:|:.|:..:.||:..
Human   339 GGHLDSLLGQCMYFGLSFSRVGADFRGQLAPVFQRVAISTFQKAIQETVEKFQEEMNSYMLISAP 403

  Fly   395 AL--HSHARKQVDPEQE-SYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHS 456
            |:  .|:....|...|. :..||..||||.|||...|..|.|.|:||||.|:|||.|||..|:.:
Human   404 AILGTSNMPAAVPATQPGTLQPPMVLLDFPPLACFLNNILVAFNDLRLCCPVALAQDVTGALEDA 468

  Fly   457 LQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGIS--- 518
            |.:..:.:|||:|.|:.||:..|:|.||:.|:....|||||:.||:..:|||..:...||.|
Human   469 LAKVTKIILAFHRAEEAAFSSGEQELFVQFCTVFLEDLVPYLNRCLQVLFPPAQIAQTLGSSDSP 533

  Fly   519 ---------------------------LLQLEQQQLTYL-------QQTR-----------ILEP 538
                                       .|::.|..|.:|       |.::           |.||
Human   534 ALAFPSSWDYRPAPPSPANVVFLREMGFLRVGQAGLEFLTSGIPPTQLSKYGNLGHVNIGAIQEP 598

  Fly   539 LKHLLPTK-ALVQPQDKVMEAKPSAGVP 565
            |..:||.: .|....|:.:..:.:|..|
Human   599 LAFILPKRETLFTLDDQALGPELTAPAP 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..355	CDD:427729	160/319 (50%)
COG8	NP_001366190.1	Dor1	50..364	CDD:427729	160/319 (50%)