DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cog8 and cog8

DIOPT Version :9

Sequence 1:	NP_609503.2	Gene:	Cog8 / 34571	FlyBaseID:	FBgn0287204	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001013524.1	Gene:	cog8 / 541379	ZFINID:	ZDB-GENE-050320-74	Length:	634	Species:	Danio rerio

Alignment Length:	549	Identity:	242/549 - (44%)
Similarity:	358/549 - (65%)	Gaps:	11/549 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MDLENERVLKLIFPDGVPDNLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAI 71
            :|:|:|.:|..||.|..|:|.|.||:...||::|..|.|::|.:|..||:||...||:||::||.
Zfish     4 VDVEDESILASIFKDSFPENWRENPDFAAYLSQLSACGVDELTREPERLSEERAQILQQTRELAF 68

  Fly    72 SNYRTFITTAENSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKN 136
            :||:|||.||:.::.|:::|...|..|..|:.|||..:.:|..|::::.|::..||:||:||.::
Zfish    69 TNYKTFIRTADCTQHIYTDFSTVENCLSKLLHKLPSFTEKCRGFIKEADEISVSRRMNSLTLNRH 133

  Fly   137 AQLLEVLELPQLMERCIREGRYEEALELAAYATRLGQHQGHIPVVTSIVRSVEALWHNMLVQLVA 201
            .::||:||:||||:.|:|.|.||||||||||..||.:....:||:..||..|......||.||:.
Zfish   134 TEILEILEIPQLMDTCVRNGYYEEALELAAYVKRLEKKHSSLPVIQGIVHEVRLSAQLMLNQLLQ 198

  Fly   202 QLRTDLQLPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITR 266
            |||::.|||.||:::||||||..|.:.|||:||||||.:||.|.|.|||..|...|::||||..|
Zfish   199 QLRSNSQLPVCLRVIGYLRRMDVFTEAELRVKFLQARGSWLRSILTAIPDEDPYFHITKTIETCR 263

  Fly   267 INLFNIITQYRAIFPEDEGTLKTQSSLRPLQGVSCNGDRLFQAWLHNKISDFLQTLERDLQLGVG 331
            ::||:|||||||||.:::       .|.|..|...|...:|..|:..:::.||:||.|||..|||
Zfish   264 VHLFDIITQYRAIFSDED-------PLLPPGGQVLNESAIFHGWVVQQVAQFLETLNRDLHRGVG 321

  Fly   332 S-VETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINKVA 395
            | ::::|||||||||||||||||||..:||||..|....|..::::..::|:.::..:|||:..:
Zfish   322 SRLDSLLGQCMYFGLSFSRVGADFRGQLAPIFQQVAMDTFRKAIQEAVDKFQEDMNLYTLISLPS 386

  Fly   396 LHSHARKQVDPEQE--SYAPPEALLDFYPLAALCNGYLSALNELRLCAPLALATDVTRCLQHSLQ 458
            :.........|..:  :..||.|||||.|||...|..|:|.|:||||.|:.||.:|:||::.:|.
Zfish   387 ILGSTIPPAIPSTQPGTLQPPMALLDFPPLACFLNNVLTAFNDLRLCCPIGLAQEVSRCIEEALI 451

  Fly   459 QAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTVHLGISLLQLE 523
            :..:.:|.|:|.|:.||:..|||.||:.||..|.|:||::.||:..:|||..|.:.||:...|:.
Zfish   452 KVTKLILVFHRAEESAFSSRERELFVQFCSAFAEDMVPFLNRCLQVLFPPAQLALILGVPPTQVS 516

  Fly   524 QQ-QLTYLQQTRILEPLKHLLPTKALVQP 551
            :. .|..:....:||||:.:||.|..|.|
Zfish   517 KYGSLGCINMNTVLEPLQFVLPQKEPVTP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..379	CDD:252394	163/342 (48%)
cog8	NP_001013524.1	Dor1	34..370	CDD:252394	163/342 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594046
Domainoid	1	1.000	321	1.000	Domainoid score	I1211
eggNOG	1	0.900	-	-		E1_KOG2069
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13018
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1460
OMA	1	1.010	-	-		QHG53892
OrthoDB	1	1.010	-	-		D1531483at2759
OrthoFinder	1	1.000	-	-		FOG0005159
OrthoInspector	1	1.000	-	-		oto41430
orthoMCL	1	0.900	-	-		OOG6_102872
Panther	1	1.100	-	-	LDO	PTHR21311
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R223
SonicParanoid	1	1.000	-	-		X4192
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800