Protein Alignment Cog8 and cogc-8

DIOPT Version :10

• Sequence 1: NP_609503.2
• Gene: Cog8 / 34571
• FlyBaseID: FBgn0287204
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_499883.1
• Gene: cogc-8 / 176841
• WormBaseID: WBGene00019820
• Length: 743
• Species: Caenorhabditis elegans
• Alignment Length: 608
• Identity: 142/608 - (23%)
• Similarity: 261/608 - (42%)
• Gaps: 116/608 - (19%)

  Fly    18 IFPDGVPDNLRGNPELDNYLAKLGTCKVEQLKKEQTRLAEEARTILEQTQDLAISNYRTFITTAE 82
            ||.:|  |::|          .:|   :|::::::..||.|.:.|..|..|||.:||.|:.....
 Worm     6 IFHNG--DDIR----------NMG---LEEMRRQKVLLASELKAIDAQISDLAFNNYGTYADAGR 55

  Fly    83 NSRSIFSEFLRSEQQLDTLVSKLPDLSVQCERFLQDSAELNEQRRLNSITLQKNAQLLEVLELPQ 147
            .:......|.....:...|..:..:|:.....|...:.:|:|::.|....|.|:..:.|:|.||.
 Worm    56 ATHDCSKTFGEMRDKTVNLSDQAEELTSAFVEFRAKAKQLSEEQDLVRKALDKSNPIWELLTLPS 120

  Fly   148 LMERCIREGRYEEALELAAYATRLGQHQGHI---PVVTSIV-RSVEALWHNMLVQLVAQLRTDLQ 208
            .|:.|||.|.|:.|..|..|..:| |.|..:   |::..:. ..|||..: :|.:|..:....|.
 Worm   121 RMDICIRAGYYDLAYTLTNYGLQL-QQQTQLYRNPLIKKVADHLVEARAY-LLEELFNKFAGPLD 183

  Fly   209 LPKCLQIVGYLRRMQAFGDNELRLKFLQARDAWLTSCLEAIPTADAQQHLSKTIEITRINLFNII 273
            |.:.:::|..:|:|.:...|:||:..||.||.:|..  :.:..:.....:.:.|||.|.::::.:
 Worm   184 LAESIKVVNNVRKMPSLTANQLRIAVLQHRDIYLEK--QILDISGNVDMIVQAIEIYRTSMYDTL 246

  Fly   274 TQYRAIFPEDEGTLKTQSS---------LRPLQGVSCNGDRLFQAWLHNKISDFLQTLER-DLQL 328
            ..|.|:|||:|...|..::         |.|        :.:...|:.:.:...|..:.: |::.
 Worm   247 VLYLAVFPENEVVRKNPNADPRWESWPVLPP--------NSILSQWVISNVKKMLDLITKADVKS 303

  Fly   329 GVGSVETVLGQCMYFGLSFSRVGADFRALMAPIFVGVIRRRFESSVEQVDEQFERELERFTLINK 393
            .| .:..|..:.|....||.|:|.|||.|:|.....:|.:||..:|::...:.........:|.
 Worm   304 AV-DLSAVWTKLMAMASSFGRMGIDFRPLIAGKLTKLIEQRFRQNVQEATSRLTGSSRDIVMIG- 366

  Fly   394 VALHSHARKQVDP------EQESYAPPEALLD---FYPLAALCNGYLSALNELR-LCAPLALATD 448
                      :||      |....:||.|..:   :..:....|..:.|||.|| :..|:.|:|.
 Worm   367 ----------IDPASLPQFETAPDSPPVAAAELSLWDDMTIYTNSVVDALNGLRFILTPVVLSTV 421

  Fly   449 VTRCLQHSLQQAAQRVLAFYRQEQQAFAGSEREAFVRLCSCLAYDLVPYIQRCIHGVFPPQSLTV 513
            |.     ||:.:.:.:|.:........|...|...: :|:.:|    |:.::|:...|||.:::.
 Worm   422 VV-----SLRDSIRSILTWLASSHSNSANFSRAVRI-VCTSVA----PFFEKCVAFFFPPATVSK 476

  Fly   514 HLGISL--------LQLEQQQLTY--------------LQQTRILEP--LKHLL-PTK------- 546
            ..|.|:        ::|:.:||..              |.|.|.||.  |:::| |||
 Worm   477 IFGSSISKRQYLQFIELDMKQLAASCDGAEKIEEIVKPLLQKRTLEEIGLENVLKPTKPEEEKTK 541

  Fly   547 -----------ALVQPQDKVMEA 558
                       .|.:||::..|:
 Worm   542 FFLEETVEDGPGLAEPQEEASES 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cog8	NP_609503.2	Dor1	37..355	CDD:427729	81/331 (24%)
cogc-8	NP_499883.1	Dor1	10..329	CDD:427729	84/346 (24%)
		2A1904	<506..738	CDD:273344	14/59 (24%)