DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and ZNF227

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	1269	Identity:	216/1269 - (17%)
Similarity:	348/1269 - (27%)	Gaps:	576/1269 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VEDNNNRVAMTKPSSEEREPNASGSMPSSP--VAEASAEEAATERTPEKEKEKDVEVDVEKPDEA 182
            ||:..|.||:             |.:|..|  |::..||          ||...:|.:.::..:.
Human    53 VENFKNLVAV-------------GHLPFQPDMVSQLEAE----------EKLWMMETETQRSSKH 94

  Fly   183 PSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFN 247
                                     ||....:.:||.|.::|
Human    95 -------------------------QNKMETLQKFALKYLSN----------------------- 111

  Fly   248 LQQQQLFQIQLIQQLQSQLA-LNQAKQEEDTEEDADQEQDQEQ-------ETDTYEEEERIADME 304
               |:|...|:.:|:.|:|. ..|.|..:..:.|:.|..:.|.       ::..|.|.:......
Human   112 ---QELSCWQIWKQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNPKGDSSIYIENQEFPFWR 173

  Fly   305 LRQK------AEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDH---ESQPNRRPSLDN 360
            .:..      :|::: :::.:|..:...:.:.|      :.:|:...|:|   :::|  :|...|
Human   174 TQHSCGNTYLSESQI-QSRGKQIDVKNNLQIHE------DFMKKSPFHEHIKTDTEP--KPCKGN 229

  Fly   361 THKADTAQDALAKLKEMENTPLPFGS-----------DLASSIITNHDDLPEPNSLDLLQK---- 410
            .:....:..:..|| .:...|.|.|.           .|..::.|......:.:.|...|:
Human   230 EYGKIISDGSNQKL-PLGEKPHPCGECGRGFSYSPRLPLHPNVHTGEKCFSQSSHLRTHQRIHPG 293

  Fly   411 ----RAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIR 471
                |..|..|..::....:..::.  .||||            :||..|||.|.|.:.|.||.|
Human   294 EKLNRCHESGDCFNKSSFHSYQSNH--TGEKS------------YRCDSCGKGFSSSTGLIIHYR 344

  Fly   472 SHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSS 536
            :||||:|:||..||..|:...|.:.|.:.|.::.|:
Human   345 THTGEKPYKCEECGKCFSQSSNFQCHQRVHTEEKPY----------------------------- 380

  Fly   537 PNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDED 601
                                         ...|..|..|.:.
Human   381 -----------------------------KCEECGKGFGWSV----------------------- 393

  Fly   602 EPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSP 666
                 |..|.::..|.|...:..||.:
Human   394 -----NLRVHQRVHRGEKPYKCEECGK-------------------------------------- 415

  Fly   667 SSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLN 731
             ...::.|.|.|..:                            |   .|:.|.:.|...:.|
Human   416 -GFTQAAHFHIHQRV----------------------------H---TGEKPYKCDVCGKGF--- 445

  Fly   732 FTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSW 796
                     .|:||:                               |.|.      |.|:.:.
Human   446 ---------SHNSPL-------------------------------ICHR------RVHTGEK-- 462

  Fly   797 ENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAF 861
                                      |.:|..|.:..:..:.|.:|:|.||||:|:||:.||:.|
Human   463 --------------------------PYKCEACGKGFTRNTDLHIHFRVHTGEKPYKCKECGKGF 501

  Fly   862 TTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDP 926
            :...||:.|..||   ...:.| :|..|.|.:|.:..||.|.|:||||
Human   502 SQASNLQVHQNVH---TGEKRF-KCETCGKGFSQSSKLQTHQRVHTGE----------------- 545

  Fly   927 PPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDV 991
                      .|:....                                       ||:|:
Human   546 ----------KPYRCDV---------------------------------------CGKDF---- 557

  Fly   992 SSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPT 1056
              .:.||..|.|                          |::|.....:......|.|..|
Human   558 --SYSSNLKLHQ--------------------------VIHTGEKPYKCEECGKGFSWRS----- 589

  Fly  1057 SPSVHASSQVIKRSSSPARSEA-----SQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSP 1116
              ::|| .|.:.....|.:.|.     || |:|........:.         |||.......:..
Human   590 --NLHA-HQRVHSGEKPYKCEQCDKSFSQ-AIDFRVHQRVHTG---------EKPYKCGVCGKGF 641

  Fly  1117 SGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAA---AAQHHHHQQMAA 1178
            |.||                      |||.| |:.|......:..|....   ::|..:||
Human   642 SQSS----------------------GLQSH-QRVHTGEKPYKCDVCGKGFRYSSQFIYHQ---- 679

  Fly  1179 LHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPF 1243
                    |....|...|.                         :|.|.|.|...|.....|...
Human   680 --------RGHTGEKPYKC-------------------------EECGKGFGRSLNLRHHQRVHT 711

  Fly  1244 GMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGST---TCGICYKTFPCHSALE 1305
            |..|::           |....:..     :.|.|.....||....   .|..|.|.|...:.||
Human   712 GEKPHI-----------CEECGKAF-----SLPSNLRVHLGVHTREKLFKCEECGKGFSQSARLE 760

  Fly  1306 IHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            .|.|.||.|:|:||.|||:.|..:..|..|...|
Human   761 AHQRVHTGEKPYKCDICDKDFRHRSRLTYHQKVH 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	11/21 (52%)
		C2H2 Zn finger	453..473	CDD:275368	10/19 (53%)
		zf-H2C2_2	465..490	CDD:290200	14/24 (58%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	826..846	CDD:275368	5/19 (26%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	22/67 (33%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1319..1339	CDD:275368	7/19 (37%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630	13/52 (25%)
		C2H2 Zn finger	326..346	CDD:275368	10/19 (53%)
		zf-H2C2_2	342..363	CDD:316026	12/20 (60%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	382..402	CDD:275368	5/47 (11%)
		COG5048	406..779	CDD:227381	121/715 (17%)
		C2H2 Zn finger	410..430	CDD:275368	5/86 (6%)
		C2H2 Zn finger	438..458	CDD:275368	8/68 (12%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		C2H2 Zn finger	494..514	CDD:275368	7/19 (37%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
		C2H2 Zn finger	550..570	CDD:275368	8/90 (9%)
		C2H2 Zn finger	578..598	CDD:275368	6/27 (22%)
		C2H2 Zn finger	606..626	CDD:275368	5/20 (25%)
		C2H2 Zn finger	634..654	CDD:275368	8/42 (19%)
		C2H2 Zn finger	662..682	CDD:275368	5/31 (16%)
		C2H2 Zn finger	690..710	CDD:275368	6/44 (14%)
		C2H2 Zn finger	718..738	CDD:275368	4/24 (17%)
		C2H2 Zn finger	746..766	CDD:275368	8/19 (42%)
		C2H2 Zn finger	774..794	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000