DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and ZNF226

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens

Alignment Length:	892	Identity:	175/892 - (19%)
Similarity:	285/892 - (31%)	Gaps:	288/892 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 KSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEK 178
            |.::.|:|.|.....||  ::..|:.|         :.|.:..:..|.:..|.|:|
Human    53 KQDVSPIERNEQLWIMT--TATRRQGN---------LGEKNQSKLITVQDRESEEE--------- 97

  Fly   179 PDEAPSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQ 243
                                     |...|..|.         |||            .|...|.
Human    98 -------------------------LSCWQIWQQ---------IAN------------DLTRCQD 116

  Fly   244 TLFNLQQ---QQLFQIQLIQQLQSQLA------LNQAKQEEDT---EEDADQEQDQEQETDTYEE 296
            ::.|..|   |..|..|:..:|..|::      :|:|....:|   |....:.||..::|...|.
Human   117 SMINNSQCHKQGDFPYQVGTELSIQISEDENYIVNKADGPNNTGNPEFPILRTQDSWRKTFLTES 181

  Fly   297 EERIADMELRQKAEARMAEAKARQHLINAGV-PL----RESSGSPAESLKRRREHDHESQPNRRP 356
            :....|.::..|  .::.:.|       .|| |:    ........:|.|..|.:|:|....:..
Human   182 QRLNRDQQISIK--NKLCQCK-------KGVDPIGWISHHDGHRVHKSEKSYRPNDYEKDNMKIL 237

  Fly   357 SLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPE-PNSLDLLQKRA-------- 412
            :.|:.....|.|    |..:......|| |||:|..:  |..|.. ..||..:::..
Human   238 TFDHNSMIHTGQ----KSYQCNECKKPF-SDLSSFDL--HQQLQSGEKSLTCVERGKGFCYSPVL 295

  Fly   413 ---QEVLDSASQGILANSMADDFAFG------------------EKSGEGKGRNEPFFKH----- 451
               |:|  ...:.:..:....:|:.|                  ::.|:|..|......|
Human   296 PVHQKV--HVGEKLKCDECGKEFSQGAHLQTHQKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHT 358

  Fly   452 -----RCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPH---- 507
                 .|..||:.|...|.||.|.|.||||:||||:.||..|:...:|:.|.:.|..:.|:
Human   359 AEKPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGKSFSRNSHLQSHQRVHTGEKPYKCEE 423

  Fly   508 -----VPMNATPIPEHMDKFHPPL-LDQMSPTDSSPNHSPAPPPLGSAPASF-----PPAFPGLQ 561
                 :..:...|.:.:.....|. .::.....|.|:...|...:.:...|:     ...|....
Human   424 CGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQAHQGVHTGEKSYICTVCGKGFTLSS 488

  Fly   562 NLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAEC 626
            ||              ..||               ::...|...|.....:..:|..|.|.....
Human   489 NL--------------QAHQ---------------RVHTGEKPYKCNECGKSFRRNSHYQVHLVV 524

  Fly   627 SEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQ 691
            ...| :|...|:..|........|:.|:.|.||            .|........|:
Human   525 HTGE-KPYKCEICGKGFSQSSYLQIHQKAHSIE------------KPFKCEECGQGF-------- 568

  Fly   692 PAALMHPQSSPGSQSHLDHLPTPGQLPPR-EDF---FAERFPLNFTTAKMLSPEHHSPVRSPAGG 752
                     :..|:..:..|...|:.|.: |:.   |:.|..|..
Human   569 ---------NQSSRLQIHQLIHTGEKPYKCEECGKGFSRRADLKI-------------------- 604

  Fly   753 ALPPGVPPPPHHHPHHMARSPF------------FNPIKHEMAALLPRPHSNDNSWENFIEVSNT 805
                       |...|....|:            .|.:.|:      |.||.:..::
Human   605 -----------HCRIHTGEKPYNCEECGKVFRQASNLLAHQ------RVHSGEKPFK-------- 644

  Fly   806 CETM-----KLKELMKNKKI---SDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFT 862
            ||..     :...|..::|:   ..|.:|..|.:.......|.||.|.||||:|:||..||:.|:
Human   645 CEECGKSFGRSAHLQAHQKVHTGDKPYKCDECGKGFKWSLNLDMHQRVHTGEKPYKCGECGKYFS 709

  Fly   863 TKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGE 909
            ...:|:.|.:||....|    ::|.||.|.:|.:..||.|.|:||||
Human   710 QASSLQLHQSVHTGEKP----YKCDVCGKVFSRSSQLQSHQRVHTGE 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	10/31 (32%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	15/24 (63%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	826..846	CDD:275368	6/19 (32%)
		zf-H2C2_2	838..863	CDD:290200	14/24 (58%)
		zf-C2H2_2	854..922	CDD:289522	22/56 (39%)
		C2H2 Zn finger	854..874	CDD:275368	6/19 (32%)
		C2H2 Zn finger	886..906	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1291..1311	CDD:275368
		zf-H2C2_2	1303..1328	CDD:290200
		C2H2 Zn finger	1319..1339	CDD:275368
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630	4/13 (31%)
		C2H2 Zn finger	256..302	CDD:275370	12/50 (24%)
		SUF4-like	306..>357	CDD:411020	6/50 (12%)
		C2H2 Zn finger	309..334	CDD:411020	2/24 (8%)
		C2H2 Zn finger	309..329	CDD:275368	2/19 (11%)
		C2H2 Zn finger	337..357	CDD:411020	4/19 (21%)
		C2H2 Zn finger	337..357	CDD:275368	4/19 (21%)
		COG5048	359..774	CDD:227381	106/502 (21%)
		C2H2 Zn finger	365..385	CDD:275368	9/19 (47%)
		C2H2 Zn finger	393..413	CDD:275368	6/19 (32%)
		C2H2 Zn finger	421..441	CDD:275368	1/19 (5%)
		C2H2 Zn finger	449..469	CDD:275368	3/19 (16%)
		C2H2 Zn finger	477..497	CDD:275368	5/48 (10%)
		C2H2 Zn finger	505..525	CDD:275368	3/19 (16%)
		C2H2 Zn finger	533..553	CDD:275368	4/19 (21%)
		C2H2 Zn finger	561..581	CDD:275368	3/36 (8%)
		C2H2 Zn finger	589..609	CDD:275368	5/50 (10%)
		C2H2 Zn finger	617..637	CDD:275368	3/25 (12%)
		C2H2 Zn finger	645..665	CDD:275368	4/19 (21%)
		C2H2 Zn finger	673..693	CDD:275368	6/19 (32%)
		C2H2 Zn finger	701..721	CDD:275368	6/19 (32%)
		C2H2 Zn finger	729..749	CDD:275368	9/19 (47%)
		C2H2 Zn finger	757..777	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000