DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salm and YY1

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_003394.1	Gene:	YY1 / 7528	HGNCID:	12856	Length:	414	Species:	Homo sapiens

Alignment Length:	414	Identity:	87/414 - (21%)
Similarity:	130/414 - (31%)	Gaps:	146/414 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 EHEQEMAECSEPEPEPLPLE------VRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHH 676
            |...|:.|..|.|.|.:|:|      |..:||..::.|.....||      .......|...|||
Human    15 EMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDH------GGGGGHGHAGHHHH 73

  Fly   677 RHSHMGYPPVV--QPI---QPAALMHPQ---------------------SSPGSQSHLDHLPTPG 715
            .|.|..:||::  ||:   .|..:.|.|                     :..|.:..: .:|.|.
Human    74 HHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQI-LIPVPA 137

  Fly   716 QLPPREDFFAERF-------------------------------------------------PLN 731
            .....:|:..:..                                                 |.|
Human   138 PAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKSGKKSYLSGGAGAAGGGGADPGN 202

  Fly   732 ----------------FTTAKMLSPE-----HHSPV-------RSP-------AGGALPP-GVPP 760
                            |:.....|.|     |.:.|       .||       .|..||| |:|.
Human   203 KKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPG 267

  Fly   761 PPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETM--KLKELMKNKKISDP 823
            .....|..:|          |.|.:.||....|::..........|..|  ....:.|:.....|
Human   268 IDLSDPKQLA----------EFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGP 322

  Fly   824 --NQCVVCDRVLSCKSALQMHYRTHTGERPFKCRI--CGRAFTTKGNLKTHMAVHKIRPPMRNFH 884
              :.|..|.:.....|.|:.|...||||:||:|..  ||:.|:...||:||:.:|....|    :
Human   323 RVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRP----Y 383

  Fly   885 QCPV--CHKKYSNALVLQQHIRLH 906
            .||.  |:||::.:..|:.||..|
Human   384 VCPFDGCNKKFAQSTNLKSHILTH 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523
		C2H2 Zn finger	453..473	CDD:275368
		zf-H2C2_2	465..490	CDD:290200
		C2H2 Zn finger	481..501	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368	5/19 (26%)
		zf-H2C2_2	838..863	CDD:290200	12/26 (46%)
		zf-C2H2_2	854..922	CDD:289522	19/57 (33%)
		C2H2 Zn finger	854..874	CDD:275368	8/21 (38%)
		C2H2 Zn finger	886..906	CDD:275368	8/21 (38%)
		C2H2 Zn finger	1291..1311	CDD:275368
		zf-H2C2_2	1303..1328	CDD:290200
		C2H2 Zn finger	1319..1339	CDD:275368
YY1	NP_003394.1	Interaction with the SMAD1/SMAD4 complex	1..170		31/161 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..81		13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..203		1/45 (2%)
		Involved in nuclear matrix association	257..341		20/93 (22%)
		COG5048	<268..407	CDD:227381	40/152 (26%)
		Binding to DNA	295..414		34/117 (29%)
		C2H2 Zn finger	298..320	CDD:275368	3/21 (14%)
		C2H2 Zn finger	327..347	CDD:275368	5/19 (26%)
		Involved in repression of activated transcription	333..371		14/37 (38%)
		C2H2 Zn finger	355..377	CDD:275368	8/21 (38%)
		Involved in masking transactivation domain	371..397		9/29 (31%)
		C2H2 Zn finger	385..407	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030