DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salm and Zfp219

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001240623.1	Gene:	Zfp219 / 69890	MGIID:	1917140	Length:	726	Species:	Mus musculus

Alignment Length:	832	Identity:	164/832 - (19%)
Similarity:	238/832 - (28%)	Gaps:	341/832 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 CRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVP-------- 509
            |..|||.|..:|.|.:|:|:|.|.:.|:|..||.|...:..|:.|.:.|..:.|..|
Mouse    63 CPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARLLLEL 127

  Fly   510 -------------------MNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPP 555
                               |.::|..|.:                      |.|.:.|:.|...|
Mouse   128 EERALLREARLGRARSSGGMQSSPAAEGL----------------------ARPQVPSSSAFRCP 170

  Fly   556 AFPG-----------LQNLYRPPMEILKSLGAAAPHQYFPQEL-----------PTDLRKPSPQL 598
            ...|           |..|:||....|.|.|::...:.....|           .|...:|.|.
Mouse   171 FCKGKFRTSAERERHLHILHRPWKCSLCSFGSSQEEELLHHSLTAHGASERPLAATSTPEPPPP- 234

  Fly   599 DEDEPQVKNEPVEEKDQREEHEQEMAEC---SEPEPEPLPLEVRIK------------------- 641
            .:.||:...||..|.:.|.|.::|....   :.||..|.|.|.|.:
Mouse   235 PQQEPRSALEPEPEPEPRPEPDREANPAPTPAPPEEPPAPPEFRCQVCGQSFTQSWFLKGHMRKH 299

  Fly   642 ---------------EERVEEQEQVKQEDHRIEPRRTPSP-SSEHRSPHHHRHSHMGYPPVVQPI 690
                           :|....:..:|....::.|.|.|.| |:..|:|.....|.:.|    :|:
Mouse   300 KASFDHACPVCGRCFKEPWFLKNHMKVHTSKLGPLRAPGPGSAPARAPQPPDLSLLAY----EPL 360

  Fly   691 QPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALP 755
            .||.|:.|..:|..:..          ||.        .|.:.:.:......:.....|.||...
Mouse   361 GPALLLAPAPAPAERRE----------PPS--------LLGYLSVRAGEVRPNGEGADPGGGRSY 407

  Fly   756 PGVPPPPHHHPHHMARSPFFNPIKHE------------------MAALLPRP------------- 789
            .|..|.|...|:...|.....|.:.|                  :.:|.|.|
Mouse   408 GGFRPLPSALPNRARRHRTEEPEEEEEVVEAEEESWARGRSLGSLTSLHPNPGEGSGQPAPAAGT 472

  Fly   790 --HSNDNSWENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPF 852
              .|.....||.:.|..|     ..|..:.....|   |..|.:.......|::|.|.||||||:
Mouse   473 QARSTATQEENGLLVGGT-----RSEAGRGATGKD---CPFCGKSFRSAHHLKVHLRVHTGERPY 529

  Fly   853 KCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQ 917
            ||..|..|.|..|:||.|                            ||:|.|           ||
Mouse   530 KCPHCDYAGTQSGSLKYH----------------------------LQRHHR-----------EQ 555

  Fly   918 IQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMD 982
            ..:|                              |||.||.|...:..|:|..:|.
Mouse   556 RSSA------------------------------GPGPPPEPPPPSQRGSLQPQSG--------- 581

  Fly   983 CGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGH 1047
                                                 .:..:..||.|..|...||.||::
Mouse   582 -------------------------------------AKPTQASATWVEGTASTRPPSSST---- 605

  Fly  1048 SVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSS---------------- 1096
            ..||...|.||.         |:....|...:: .|||:.||.|...:.
Mouse   606 GPGSRRKPASPG---------RTLRNGRGGEAE-PLDLSLRAGPGGEAGAGGALHRCLFCPFATG 660

  Fly  1097 -------------SRSPLPKEKP--VSPPSLPRSPSGSSHASANILTSPLPP 1133
                         ||....:.:|  .:.|:..|:|||.        |.|.||
Mouse   661 APELMALHLQVHHSRRARGRRQPRADTSPTYVRAPSGE--------TPPSPP 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	9/19 (47%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	10/24 (42%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		C2H2 Zn finger	826..846	CDD:275368	5/19 (26%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	14/67 (21%)
		C2H2 Zn finger	854..874	CDD:275368	8/19 (42%)
		C2H2 Zn finger	886..906	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1291..1311	CDD:275368
		zf-H2C2_2	1303..1328	CDD:290200
		C2H2 Zn finger	1319..1339	CDD:275368
Zfp219	NP_001240623.1	C2H2 Zn finger	63..83	CDD:275368	9/19 (47%)
		C2H2 Zn finger	91..111	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..164		5/46 (11%)
		C2H2 Zn finger	169..187	CDD:275368	2/17 (12%)
		C2H2 Zn finger	195..211	CDD:275368	3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..278		16/60 (27%)
		zf-C2H2	277..299	CDD:395048	1/21 (5%)
		C2H2 Zn finger	279..299	CDD:275368	0/19 (0%)
		zf-C2H2	305..327	CDD:395048	2/21 (10%)
		C2H2 Zn finger	307..327	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..498		19/111 (17%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		zf-C2H2	503..523	CDD:395048	5/19 (26%)
		zf-H2C2_2	515..537	CDD:404364	12/21 (57%)
		zf-H2C2_5	529..552	CDD:404746	11/50 (22%)
		C2H2 Zn finger	531..551	CDD:275368	10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..645		39/228 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..726		12/39 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930