DRSC/TRiP Functional Genomics Resources

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Protein Alignment salm and SALL4

DIOPT Version :10

Sequence 1:NP_723670.2 Gene:salm / 34569 FlyBaseID:FBgn0261648 Length:1365 Species:Drosophila melanogaster
Sequence 2:NP_065169.1 Gene:SALL4 / 57167 HGNCID:15924 Length:1053 Species:Homo sapiens


Alignment Length:1369 Identity:332/1369 - (24%)
Similarity:484/1369 - (35%) Gaps:541/1369 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 EEEQPEEQSTSEQSIPEQSTPD-------------------HQLENDIKSEAKSEIEPVEDNNNR 126
            ||:|.|:|       |:|.||:                   |...:::.||.::.::.:......
Human    15 EEDQGEQQ-------PQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETH 72

  Fly   127 VAMTKPSSE--------EREPNASGSMP-------SSPVAEASAEEAATERTPEKEKEKDV---- 172
            |. .|..:|        |.:.|.:.:.|       ..||.......|.....|.....||.    
Human    73 VC-EKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHREN 136

  Fly   173 ----EVDVEKPDEAPSSAVPSTEVTLPGG------------AGAPVTLEAIQNMQMAIAQFAAKT 221
                |...|||| |.|.....||..||..            |...|||:|::..::|:.|.:|..
Human   137 GGSSEDMKEKPD-AESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADA 200

  Fly   222 IANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQL------ALNQAKQEEDTEED 280
            :.....||::      :.::.:.:..||||||.||||.:|::.|:      ||:.:....||.:.
Human   201 LPAPVPGANS------IPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKT 259

  Fly   281 ADQEQDQEQETDTYEEEERIADMELRQKA--EARMAEAKARQHLINAGVPLRESSGSPAESLKRR 343
            ......|:...         |...|.|||  :....:|..:..|.:|.:|...||.||       
Human   260 LGSHMSQQVSA---------AVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSP------- 308

  Fly   344 REHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLL 408
                                      .||..     |..|.|:.:..::::.   ||        
Human   309 --------------------------GLAPF-----TLKPDGTRVLPNVMSR---LP-------- 331

  Fly   409 QKRAQEVLDSASQGILANSMADDFAFG-EKSGEGKGRN------EP-----FFKHRCRYCGKVFG 461
                ..:|..|...:|..|.....|.. .|.|:||..|      :|     .:||:|:||.||||
Human   332 ----SALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFG 392

  Fly   462 SDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPL 526
            :||:||||:|||||||||.|:|||.||||||||||||.||    |.|..|.....|..||     
Human   393 TDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRH----PQVKANPQLFAEFQDK----- 448

  Fly   527 LDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQEL---- 587
               ::..:..|.....|.|:..         |.| :|...|:.:..|:|       .||.|    
Human   449 ---VAAGNGIPYALSVPDPIDE---------PSL-SLDSKPVLVTTSVG-------LPQNLSSGT 493

  Fly   588 -PTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQV 651
             |.||...|                                      ||.:::            
Human   494 NPKDLTGGS--------------------------------------LPGDLQ------------ 508

  Fly   652 KQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPT-PG 715
                        |.||                              |:|..|        || ||
Human   509 ------------PGPS------------------------------PESEGG--------PTLPG 523

  Fly   716 QLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKH 780
                                  :.|.::||   .|||....|.|.|                   
Human   524 ----------------------VGPNYNSP---RAGGFQGSGTPEP------------------- 544

  Fly   781 EMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHY 843
                                    ..||:||::|::|  |..:|||:|::|.|||||:|:|:|||
Human   545 ------------------------GSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHY 585

  Fly   844 RTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTG 908
            |||||||||:|:||||||:||||||||:.||:....::..|.||:|.||::||::||||||:|.|
Human   586 RTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMG 650

  Fly   909 EPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPG--PNHGAHNGALGSE 971
            .....||                                 ||..|....|  |.....||:.|: 
Human   651 GQIPNTP---------------------------------LPENPCDFTGSEPMTVGENGSTGA- 681

  Fly   972 SSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPV 1036
                      .|.:|..:.:..|.:|:    ||...|                            
Human   682 ----------ICHDDVIESIDVEEVSS----QEAPSS---------------------------- 704

  Fly  1037 RPRSSASSHGHSVGSTSAPTS-PSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSP 1100
                          |:..||. ||:|        |:||....|...:||...:..|         
Human   705 --------------SSKVPTPLPSIH--------SASPTLGFAMMASLDAPGKVGP--------- 738

  Fly  1101 LPKEKPVSPPSLPRSPS---GSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAV 1162
                   :|.:|.|..|   ||..:..  ||:.....:|        ....|.:...:::..:  
Human   739 -------APFNLQRQGSRENGSVESDG--LTNDSSSLMG--------DQEYQSRSPDILETTS-- 784

  Fly  1163 AAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGP 1227
                      .|.::..:...|.::.::.:|..||               ::...:|.:.:    
Human   785 ----------FQALSPANSQAESIKSKSPDAGSKA---------------ESSENSRTEME---- 820

  Fly  1228 GAGPPPNPLMGARPPF------GMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVR 1286
            |....|:..:.|.|.:      |.|..     |:|          ::..:.|.....|...:...
Human   821 GRSSLPSTFIRAPPTYVKVEVPGTFVG-----PST----------LSPGMTPLLAAQPRRQAKQH 870

  Fly  1287 GSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETFRN 1351
            |.|.||   |.|...|||:||.|:||.|:||.|:||.|.||||||||.|.:||...:......|.
Human   871 GCTRCG---KNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRK 932

  Fly  1352 RAVK 1355
            .|::
Human   933 LAIE 936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
salmNP_723670.2 SUF4-like 450..520 CDD:411020 46/69 (67%)
C2H2 Zn finger 453..474 CDD:411020 15/20 (75%)
C2H2 Zn finger 453..473 CDD:275368 14/19 (74%)
C2H2 Zn finger 481..501 CDD:411020 16/19 (84%)
C2H2 Zn finger 481..501 CDD:275368 16/19 (84%)
SUF4-like 826..>876 CDD:411020 38/49 (78%)
C2H2 Zn finger 826..847 CDD:411020 14/20 (70%)
C2H2 Zn finger 826..846 CDD:275368 13/19 (68%)
C2H2 Zn finger 854..874 CDD:411020 15/19 (79%)
C2H2 Zn finger 854..874 CDD:275368 15/19 (79%)
C2H2 Zn finger 886..906 CDD:275368 13/19 (68%)
SUF4-like 1291..>1341 CDD:411020 30/49 (61%)
C2H2 Zn finger 1291..1312 CDD:411020 10/20 (50%)
C2H2 Zn finger 1291..1311 CDD:275368 10/19 (53%)
zf-C2H2 1317..1339 CDD:395048 14/21 (67%)
C2H2 Zn finger 1319..1339 CDD:411020 13/19 (68%)
C2H2 Zn finger 1319..1339 CDD:275368 13/19 (68%)
SALL4NP_065169.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 12/53 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..149 9/33 (27%)
SUF4-like 381..>429 CDD:411020 38/47 (81%)
C2H2 Zn finger 384..405 CDD:411020 15/20 (75%)
C2H2 Zn finger 384..404 CDD:275368 14/19 (74%)
C2H2 Zn finger 412..432 CDD:275368 16/19 (84%)
C2H2 Zn finger 412..429 CDD:411020 14/16 (88%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 483..546 29/237 (12%)
C2H2 Zn finger 568..588 CDD:275368 13/19 (68%)
zf-H2C2_2 580..605 CDD:463886 20/24 (83%)
C2H2 Zn finger 596..619 CDD:275368 17/22 (77%)
zf-C2H2 626..648 CDD:395048 14/21 (67%)
C2H2 Zn finger 628..648 CDD:275368 13/19 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..714 8/65 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 736..776 11/65 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 788..828 7/58 (12%)
SUF4-like 872..>919 CDD:411020 29/49 (59%)
C2H2 Zn finger 872..893 CDD:411020 11/23 (48%)
C2H2 Zn finger 872..892 CDD:275368 11/22 (50%)
C2H2 Zn finger 900..920 CDD:275368 13/19 (68%)
C2H2 Zn finger 900..919 CDD:411020 13/18 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1018..1039
Blue background indicates that the domain is not in the aligned region.

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