DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and SALL4

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_065169.1	Gene:	SALL4 / 57167	HGNCID:	15924	Length:	1053	Species:	Homo sapiens

Alignment Length:	1369	Identity:	332/1369 - (24%)
Similarity:	484/1369 - (35%)	Gaps:	541/1369 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EEEQPEEQSTSEQSIPEQSTPD-------------------HQLENDIKSEAKSEIEPVEDNNNR 126
            ||:|.|:|       |:|.||:                   |...:::.||.::.::.:......
Human    15 EEDQGEQQ-------PQQQTPEFADAAPAAPAAGELGAPVNHPGNDEVASEDEATVKRLRREETH 72

  Fly   127 VAMTKPSSE--------EREPNASGSMP-------SSPVAEASAEEAATERTPEKEKEKDV---- 172
            |. .|..:|        |.:.|.:.:.|       ..||.......|.....|.....||.
Human    73 VC-EKCCAEFFSISEFLEHKKNCTKNPPVLIMNDSEGPVPSEDFSGAVLSHQPTSPGSKDCHREN 136

  Fly   173 ----EVDVEKPDEAPSSAVPSTEVTLPGG------------AGAPVTLEAIQNMQMAIAQFAAKT 221
                |...|||| |.|.....||..||..            |...|||:|::..::|:.|.:|..
Human   137 GGSSEDMKEKPD-AESVVYLKTETALPPTPQDISYLAKGKVANTNVTLQALRGTKVAVNQRSADA 200

  Fly   222 IANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQL------ALNQAKQEEDTEED 280
            :.....||::      :.::.:.:..||||||.||||.:|::.|:      ||:.:....||.:.
Human   201 LPAPVPGANS------IPWVLEQILCLQQQQLQQIQLTEQIRIQVNMWASHALHSSGAGADTLKT 259

  Fly   281 ADQEQDQEQETDTYEEEERIADMELRQKA--EARMAEAKARQHLINAGVPLRESSGSPAESLKRR 343
            ......|:...         |...|.|||  :....:|..:..|.:|.:|...||.||
Human   260 LGSHMSQQVSA---------AVALLSQKAGSQGLSLDALKQAKLPHANIPSATSSLSP------- 308

  Fly   344 REHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLL 408
                                      .||..     |..|.|:.:..::::.   ||
Human   309 --------------------------GLAPF-----TLKPDGTRVLPNVMSR---LP-------- 331

  Fly   409 QKRAQEVLDSASQGILANSMADDFAFG-EKSGEGKGRN------EP-----FFKHRCRYCGKVFG 461
                ..:|..|...:|..|.....|.. .|.|:||..|      :|     .:||:|:||.||||
Human   332 ----SALLPQAPGSVLFQSPFSTVALDTSKKGKGKPPNISAVDVKPKDEAALYKHKCKYCSKVFG 392

  Fly   462 SDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPL 526
            :||:||||:|||||||||.|:|||.||||||||||||.||    |.|..|.....|..||
Human   393 TDSSLQIHLRSHTGERPFVCSVCGHRFTTKGNLKVHFHRH----PQVKANPQLFAEFQDK----- 448

  Fly   527 LDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQEL---- 587
               ::..:..|.....|.|:..         |.| :|...|:.:..|:|       .||.|
Human   449 ---VAAGNGIPYALSVPDPIDE---------PSL-SLDSKPVLVTTSVG-------LPQNLSSGT 493

  Fly   588 -PTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQV 651
             |.||...|                                      ||.:::
Human   494 NPKDLTGGS--------------------------------------LPGDLQ------------ 508

  Fly   652 KQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPT-PG 715
                        |.||                              |:|..|        || ||
Human   509 ------------PGPS------------------------------PESEGG--------PTLPG 523

  Fly   716 QLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKH 780
                                  :.|.::||   .|||....|.|.|
Human   524 ----------------------VGPNYNSP---RAGGFQGSGTPEP------------------- 544

  Fly   781 EMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHY 843
                                    ..||:||::|::|  |..:|||:|::|.|||||:|:|:|||
Human   545 ------------------------GSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHY 585

  Fly   844 RTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTG 908
            |||||||||:|:||||||:||||||||:.||:....::..|.||:|.||::||::||||||:|.|
Human   586 RTHTGERPFQCKICGRAFSTKGNLKTHLGVHRTNTSIKTQHSCPICQKKFTNAVMLQQHIRMHMG 650

  Fly   909 EPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPG--PNHGAHNGALGSE 971
            .....||                                 ||..|....|  |.....||:.|:
Human   651 GQIPNTP---------------------------------LPENPCDFTGSEPMTVGENGSTGA- 681

  Fly   972 SSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPV 1036
                      .|.:|..:.:..|.:|:    ||...|
Human   682 ----------ICHDDVIESIDVEEVSS----QEAPSS---------------------------- 704

  Fly  1037 RPRSSASSHGHSVGSTSAPTS-PSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSP 1100
                          |:..||. ||:|        |:||....|...:||...:..|
Human   705 --------------SSKVPTPLPSIH--------SASPTLGFAMMASLDAPGKVGP--------- 738

  Fly  1101 LPKEKPVSPPSLPRSPS---GSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAV 1162
                   :|.:|.|..|   ||..:..  ||:.....:|        ....|.:...:::..:
Human   739 -------APFNLQRQGSRENGSVESDG--LTNDSSSLMG--------DQEYQSRSPDILETTS-- 784

  Fly  1163 AAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGP 1227
                      .|.::..:...|.::.::.:|..||               ::...:|.:.:
Human   785 ----------FQALSPANSQAESIKSKSPDAGSKA---------------ESSENSRTEME---- 820

  Fly  1228 GAGPPPNPLMGARPPF------GMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVR 1286
            |....|:..:.|.|.:      |.|..     |:|          ::..:.|.....|...:...
Human   821 GRSSLPSTFIRAPPTYVKVEVPGTFVG-----PST----------LSPGMTPLLAAQPRRQAKQH 870

  Fly  1287 GSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETFRN 1351
            |.|.||   |.|...|||:||.|:||.|:||.|:||.|.||||||||.|.:||...:......|.
Human   871 GCTRCG---KNFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRK 932

  Fly  1352 RAVK 1355
            .|::
Human   933 LAIE 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	15/21 (71%)
		C2H2 Zn finger	453..473	CDD:275368	14/19 (74%)
		zf-H2C2_2	465..490	CDD:290200	19/24 (79%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	13/19 (68%)
		zf-H2C2_2	838..863	CDD:290200	20/24 (83%)
		zf-C2H2_2	854..922	CDD:289522	35/67 (52%)
		C2H2 Zn finger	854..874	CDD:275368	15/19 (79%)
		C2H2 Zn finger	886..906	CDD:275368	13/19 (68%)
		C2H2 Zn finger	1291..1311	CDD:275368	10/19 (53%)
		zf-H2C2_2	1303..1328	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1319..1339	CDD:275368	13/19 (68%)
SALL4	NP_065169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		12/53 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..149		9/33 (27%)
		zf-C2H2	382..404	CDD:306579	15/21 (71%)
		C2H2 Zn finger	384..404	CDD:275368	14/19 (74%)
		zf-H2C2_2	396..421	CDD:316026	19/24 (79%)
		C2H2 Zn finger	412..432	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..546		29/237 (12%)
		C2H2 Zn finger	568..588	CDD:275368	13/19 (68%)
		zf-H2C2_2	580..605	CDD:316026	20/24 (83%)
		C2H2 Zn finger	596..619	CDD:275368	17/22 (77%)
		zf-C2H2	626..648	CDD:306579	14/21 (67%)
		C2H2 Zn finger	628..648	CDD:275368	13/19 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..714		8/65 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..776		11/65 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..828		7/58 (12%)
		C2H2 Zn finger	872..892	CDD:275368	11/22 (50%)
		zf-C2H2	872..892	CDD:306579	11/22 (50%)
		zf-H2C2_2	884..909	CDD:316026	15/24 (63%)
		C2H2 Zn finger	900..920	CDD:275368	13/19 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12034
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1625
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm41403
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.930