DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sall2

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_017207469.2	Gene:	sall2 / 568044	ZFINID:	ZDB-GENE-030829-32	Length:	1254	Species:	Danio rerio

Alignment Length:	1499	Identity:	326/1499 - (21%)
Similarity:	484/1499 - (32%)	Gaps:	525/1499 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EENGGCSPLTTATTTASPSRS----------PEPEEEQPEEQSTSEQS-----IPEQ-------- 98
            ||:.....||:.....|.|.|          |.|..|:.:..|.:..|     ||.|
Zfish    26 EEHPAVKSLTSTLGHNSSSHSTRQSCKSTLNPTPPIERLKTSSPTRASHRVVHIPCQPLQLTLNL 90

  Fly    99 ---------STPDHQLENDIKSEAKSEIEPVEDNNNR----------VAMTKPSSEEREPNASGS 144
                     ..|.|.....||:.|.:    |..:.:.          |:.|..||......||..
Zfish    91 KGSHLSHIPDIPSHLTNQCIKTTAST----VSTHKHSCLLMASPKLGVSATTTSSSSSSVAASLC 151

  Fly   145 MPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTLEAIQN 209
            :|..|.:.:|..:.                   .|.....|:.|||..:.|  |.|||:
Zfish   152 VPPHPGSPSSGPQG-------------------PPSPVTPSSSPSTVPSAP--ACAPVS------ 189

  Fly   210 MQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQ-LALNQAKQ 273
                                        :||:.:.|..|||:|:.|:|:.:::..| |.|.....
Zfish   190 ----------------------------IAFILEELRVLQQRQIHQMQMTEEICRQVLRLGGGPC 226

  Fly   274 EEDTE------------EDADQEQDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHLINAG 326
            |.|::            :.:|                                         |..
Zfish   227 EVDSKPCILPSLPQFCLKGSD-----------------------------------------NNP 250

  Fly   327 VPLRESSGSPAESL------------KRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMEN 379
            .|.|..|.||..|:            .:..:|.:......||     |||..............:
Zfish   251 RPSRPKSSSPPSSVAPLLACFSSLLPPQSSKHSNPLLNVLRP-----HKAQYDSVVTTPTNYTSH 310

  Fly   380 TPLPFGSDLASSIITNHDDLPEPNSLDL-LQKRAQEVLDSASQGI-----------LANSMADDF 432
            |.....|.:::.:.:|:   |...||.| .||.:.....|...|:           :.:..:.|.
Zfish   311 TSASTSSSMSTPVASNY---PLTLSLGLPTQKSSNTTGASGHSGLPFQNQSLPVAAVPSGPSQDL 372

  Fly   433 AFGEKSGE---GKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNL 494
            ....::|.   ..||    .:|.||:|.|:|.|||:||||:||||||||::|.||.|||||:|||
Zfish   373 KLSAQAGSSVLSSGR----MQHACRFCRKLFSSDSSLQIHLRSHTGERPYQCPVCFSRFTTRGNL 433

  Fly   495 KVHFQRHAQKFPHVPMNATPIP-----------------------EHMDKFHPPLLDQMSPTDSS 536
            ||||.||.::.|.:..:..|..                       .:..:.|....|.....||.
Zfish   434 KVHFLRHREQNPELSFSLFPCSLFASVTGGSMGGSAQTQTVTSTNTNTTQRHQKQQDDDLCVDSL 498

  Fly   537 PNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDED 601
            ..   |.....:..:|.||:..  ..|......:|:...|||..........|.....|......
Zfish   499 EG---ATASTRATASSLPPSID--LALLTTAHSLLQLNCAAAAAAAAAASTSTTSSITSSSSSSL 558

  Fly   602 EPQVKNEPVEEKDQ-----REEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPR 661
            ...:.:.|......     :...:|...|.:.|.|..||
Zfish   559 ASTLLSSPASSTSSIAGVYKGVKQQRFDENTPPIPTLLP-------------------------- 597

  Fly   662 RTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAE 726
                         |..:|.:...|        .:..|.||  |..||.|    |.|.|
Zfish   598 -------------HTAYSQLANLP--------KIFFPASS--SHHHLGH----GFLRP------- 628

  Fly   727 RFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHH-----------PHHMARSPFFNPIKH 780
                  ||              |||..|     |.|.||           |.....:...:.::.
Zfish   629 ------TT--------------PAGSFL-----PSPQHHITFPFTSSSTAPSISTPTSDTSKLQR 668

  Fly   781 EMAALLPRPHSNDNSWENFI--------EVSNT-----------------------CETMKL--- 811
            .:..|...||...| ||:.|        .||.|                       ..|:::
Zfish   669 LVEKLEKEPHGQTN-WESSIGETSTSGNSVSGTLTYSSSGLMSTSTYSTNVVTSLPSSTVQIPSS 732

  Fly   812 ---KE-----LMKNKKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLK 868
               ||     ||.:.....||||.||.|||||..||::|..||.|||||.|::|||:|:|||:|:
Zfish   733 LFSKESPYMGLMNSAGTLAPNQCSVCLRVLSCPRALRLHQATHLGERPFPCKLCGRSFSTKGSLR 797

  Fly   869 THMAVHKIRPP-MRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMP 932
            .|:|.|:.||| .|..:.||:|.:|::||||||.|||:|.|...               ||..||
Zfish   798 AHLATHRARPPNSRAQNSCPLCQRKFTNALVLQHHIRMHLGGQL---------------PPEHMP 847

  Fly   933 GHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDVSSEHLS 997
                                                         |.:.:|.       |..|
Zfish   848 ---------------------------------------------DTSTECD-------SQSH-- 858

  Fly   998 NSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHA 1062
            :.::|..|     .::..|.:..|.|..|          |...|.|||..|:..:.|||...| .
Zfish   859 SQSIEPSG-----SENTPSTVDVQLLHAD----------RQTISDSSHTESLAVSIAPTVCPV-T 907

  Fly  1063 SSQVIKRSSSPARS-EASQG-ALDLTPRAAPT-----SSSSSRSPLPKEKPVS---PPSLPRSPS 1117
            ||....|||.|..: :.|.| :|:|||::.||     ...|...|.|.|...|   |.|...|.|
Zfish   908 SSLPASRSSGPIPAFDLSPGPSLNLTPQSPPTFIADPPELSLNIPSPVESAASLFPPTSQSASTS 972

  Fly  1118 GS--------------------SHASANILTSP------LPPTVGIDCLP-PGLQHHLQQQHQHL 1155
            |:                    |..||.:.|||      :.....:..:| .|.:.:|:.    |
Zfish   973 GTTANDEVCFELSSNTAYLGDISSTSALMNTSPQENDCEVSENRSLSAVPCSGSRSNLED----L 1033

  Fly  1156 MQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARD 1220
            :..||..|:.|:..|......:.|     .||.|:..:|.  ........:.....:..|.:..:
Zfish  1034 LSIQAHNASRASRTHPVSPPSSPL-----VLRSESVSSQN--VRLEEPDQSLVQTSKSLPQEFPN 1091

  Fly  1221 QRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAM---------------NQIAQS 1270
            :::....|...|.|   |.:.|..:..:..:.....|:...:|:               ...:..
Zfish  1092 EQKTEDKGRKTPKN---GQKTPPELSTDQDMLSDTVTKTSEDAVESEEADTHVQKITKDTHFSSD 1153

  Fly  1271 VMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQH 1335
            .|..|..|....:.: ..|...:|....|....      ...:::.:.||.|.:.:.::..||.|
Zfish  1154 AMDKADLNDATATEI-DRTEPTVCISLTPSLPP------PMPEKKIYHCSECGKEYASRSGLKGH 1211

  Fly  1336 MLTH 1339
            |..|
Zfish  1212 MKHH 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	14/21 (67%)
		C2H2 Zn finger	453..473	CDD:275368	13/19 (68%)
		zf-H2C2_2	465..490	CDD:290200	18/24 (75%)
		C2H2 Zn finger	481..501	CDD:275368	15/19 (79%)
		C2H2 Zn finger	826..846	CDD:275368	11/19 (58%)
		zf-H2C2_2	838..863	CDD:290200	15/24 (63%)
		zf-C2H2_2	854..922	CDD:289522	31/68 (46%)
		C2H2 Zn finger	854..874	CDD:275368	11/19 (58%)
		C2H2 Zn finger	886..906	CDD:275368	13/19 (68%)
		C2H2 Zn finger	1291..1311	CDD:275368	2/19 (11%)
		zf-H2C2_2	1303..1328	CDD:290200	3/24 (13%)
		C2H2 Zn finger	1319..1339	CDD:275368	7/19 (37%)
sall2	XP_017207469.2	C2H2 Zn finger	392..412	CDD:275368	13/19 (68%)
		zf-H2C2_2	404..429	CDD:316026	18/24 (75%)
		C2H2 Zn finger	420..440	CDD:275368	15/19 (79%)
		C2H2 Zn finger	755..775	CDD:275368	11/19 (58%)
		zf-H2C2_2	767..792	CDD:316026	15/24 (63%)
		C2H2 Zn finger	783..803	CDD:275368	11/19 (58%)
		C2H2 Zn finger	816..836	CDD:275368	13/19 (68%)
		XPG_I	<838..>1149	CDD:331126	77/409 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9042
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020