DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sall3b

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001038615.1	Gene:	sall3b / 568041	ZFINID:	ZDB-GENE-030131-9140	Length:	1247	Species:	Danio rerio

Alignment Length:	1411	Identity:	367/1411 - (26%)
Similarity:	545/1411 - (38%)	Gaps:	445/1411 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EEEQPEEQSTSEQSIPEQSTPDHQL------ENDIKSEAKSEIEPVE----------------DN 123
            ::.:|:...:.|:......:||:.|      |.|..:|::|..|...                ::
Zfish     5 KQAKPQHLRSDEEGTQSDKSPDNALLLRGGDEEDSGTESRSGGEETHVCERCCAEFFKWSEMLEH 69

  Fly   124 NNRVAMTKP---SSEEREPNASGSMPSSPVAEASAEEAATERT-------------PEKEK--EK 170
            ..:.....|   ..|:.|...|...|:..:..|.::.|..|.:             ||:..  :.
Zfish    70 QQKCTEDPPVLIVKEKEEKVISRGSPTESLFSAQSDSAEMEASEINSELAEKVDEMPEETHIIDL 134

  Fly   171 DVEVDVEKP------------DEAPSSAVPSTEVT----LPGGAGAPVTLEAIQNMQMAIAQFAA 219
            |.::|:..|            |:..:::.|:..:|    :|   ...||||.:.:.::|:|||:.
Zfish   135 DEQMDISLPEHKTSNLSPLPLDDENATSPPAPPITNHYDMP---STNVTLEILHSTRVAVAQFSQ 196

  Fly   220 KTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQE 284
            .....||.|..|.||:..:  |:| |..|||||:.|:|||:|::||:|:...:..:.....|.:.
Zfish   197 SIHCAGSAGKLNSAAIPMI--LEQ-LMALQQQQVQQLQLIEQIRSQVAVMNRQPTQAALNPASKS 258

  Fly   285 QDQEQETDTYE--------EEERIADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLK 341
            ...:..|..::        ....:....:..:|....|...||..|::       |..|..:...
Zfish   259 LPSDSNTYNFQGIAPPPVLPLSGVMPSTVNGQASVSQASMLARPSLLS-------SQPSTGQIGS 316

  Fly   342 RRREHDHESQPNRRPSLDNTHKAD----TAQDALAKLKEME--NTPLPFGSDLASSIITNHDDLP 400
            |..:....|..:..|.|.:...|.    |...:|:.:...:  :||.|. |...||:::...:||
Zfish   317 RALDSATSSLTSSSPHLFSYSGASPLLPTCSGSLSNVSNTQSVSTPSPL-SACQSSLLSPSANLP 380

  Fly   401 -----EPNSLDLLQKRAQEVLDSASQGILANSMA-DDFAFGEKSGEGK-----------GRNEPF 448
                 .||.:         :..:....|.|.:.| |..|...|..:||           ...:||
Zfish   381 LLPQSPPNGV---------IFPNPLASIAATASALDPLAAMMKHRKGKLPSVSIFDSKPSSEDPF 436

  Fly   449 FKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNAT 513
            |||:||:|.||||||||||||:||||||||||||:||:||:||||||||||||.:|:|||.||..
Zfish   437 FKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHVQMNPY 501

  Fly   514 PIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPA---SFP--PAFPGLQNLYRPP-MEILK 572
            |:||::|..         ||.|...:..:.||..:.|.   |.|  |..|....|..|| :.|::
Zfish   502 PVPEYLDNI---------PTSSGIPYGMSFPPEKAGPTWLDSKPVLPTVPSSVGLQLPPTVPIIE 557

  Fly   573 SLG---AAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKD-------QREEHEQEMAECS 627
            ||.   .:.|.:..|       .:|||...|..|...|....|.|       .:...|.|:.:..
Zfish   558 SLSDSFTSTPSERSP-------HRPSPARGELAPSSPNPTGTETDVSTIAASPKSNREAEITQSF 615

  Fly   628 EPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQP 692
            ..|...||....|                     |..|.|:
Zfish   616 NTEEVHLPSNSLI---------------------RNGSNSN------------------------ 635

  Fly   693 AALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPG 757
             .|:       |||.|...|..|.:|...|          ..:.::.|            :.||.
Zfish   636 -ILL-------SQSMLTETPVKGNVPESTD----------VPSAIIKP------------SSPPL 670

  Fly   758 VPPPPHHHPHHMARSPF-FNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN--KK 819
            :        ....||.| |..::..|                     .|.||.||::|::|  ||
Zfish   671 I--------SDQFRSKFPFGGLQDSM---------------------QTSETSKLQQLVENIDKK 706

  Fly   820 ISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFH 884
            :.:|||||:|.|||||:|||:||||.|||||||||::||||||||||||||..||:.:||:|..|
Zfish   707 MMEPNQCVICHRVLSCQSALKMHYRIHTGERPFKCKVCGRAFTTKGNLKTHFGVHRAKPPLRIQH 771

  Fly   885 QCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGAL 949
            .||:|.||::||:|||||||:|.|                                      |.:
Zfish   772 SCPICQKKFTNAVVLQQHIRMHMG--------------------------------------GQI 798

  Fly   950 PGGPGGPPGPNHGAHNGALGSESSQGDMD-DNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDD 1013
            |..|              |.....:.|.| ::.|....||||.    |.:.:.|:|||...:.::
Zfish   799 PNTP--------------LAETIYEKDTDMESFDSMSTYDDDC----LDDISFEEEGDVVENSEN 845

  Fly  1014 FKSLLFEQKLRI------------------------DATGVVNTNPV-----RPRSSASS-HGHS 1048
            ..|...:....|                        :...:|..:|:     .|.:|... ..||
Zfish   846 TLSSFSDSPPPISSLPSSISESQNVGGDLSINLSQSNGKKMVRCDPMDNDLHAPHTSTGEMENHS 910

  Fly  1049 VGSTSAP-TSPSVHASSQVIKRSSSPARSEASQGALDL---TPRAAPTSSSSSRSPLPKEKPVSP 1109
            :|::..| :|.|:|..:.   .:|.|........:|:|   ||.||....|.| :..|....|:.
Zfish   911 MGNSLMPHSSSSIHIPTY---SNSQPEGQHEHSVSLNLSSKTPEAAAIVKSES-TDCPAANAVNG 971

  Fly  1110 PSLPRS---PSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHH 1171
            .:|.::   |..||....|        ...:.|        ..::|:::
Zfish   972 VTLNQTGIQPIKSSVKKEN--------PFNVQC--------FSKEHENV---------------- 1004

  Fly  1172 HHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPL 1236
                            :.:.|...|....|.....:..::..       ..:||       |.|.
Zfish  1005 ----------------QRSTEQDTKNLPTAVKLEMSICSRPY-------MLKEG-------PFPA 1039

  Fly  1237 MGARPPFG----MFPNLPLF----PPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGI 1293
            .|.:.|..    |.|.:...    ||..|....|                            |..
Zfish  1040 FGLQSPTSRSEVMIPGVTSLTGPPPPRRTPKQHN----------------------------CSA 1076

  Fly  1294 CYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            |.|.|...|||:||.|:||.|:||.||:|.|.||||||||.||.||
Zfish  1077 CGKNFSSASALQIHERTHTGEKPFGCSVCGRAFTTKGNLKVHMGTH 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	15/19 (79%)
		zf-H2C2_2	838..863	CDD:290200	20/24 (83%)
		zf-C2H2_2	854..922	CDD:289522	37/67 (55%)
		C2H2 Zn finger	854..874	CDD:275368	15/19 (79%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	10/19 (53%)
		zf-H2C2_2	1303..1328	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1319..1339	CDD:275368	14/19 (74%)
sall3b	NP_001038615.1	C2H2 Zn finger	441..461	CDD:275368	16/19 (84%)
		zf-H2C2_2	453..478	CDD:290200	21/24 (88%)
		C2H2 Zn finger	469..489	CDD:275368	16/19 (84%)
		C2H2 Zn finger	713..733	CDD:275368	15/19 (79%)
		zf-H2C2_2	725..750	CDD:290200	20/24 (83%)
		C2H2 Zn finger	741..761	CDD:275368	15/19 (79%)
		zf-C2H2	771..793	CDD:278523	15/21 (71%)
		C2H2 Zn finger	773..793	CDD:275368	14/19 (74%)
		zf-C2H2_jaz	1071..1093	CDD:288983	10/49 (20%)
		C2H2 Zn finger	1074..1094	CDD:275368	10/19 (53%)
		zf-H2C2_2	1086..1111	CDD:290200	15/24 (63%)
		C2H2 Zn finger	1102..1122	CDD:275368	14/19 (74%)
		zf-C2H2	1102..1122	CDD:278523	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1708
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.070