DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and si:ch211-212k18.5

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_021333427.1	Gene:	si:ch211-212k18.5 / 562900	ZFINID:	ZDB-GENE-030131-379	Length:	1139	Species:	Danio rerio

Alignment Length:	1424	Identity:	318/1424 - (22%)
Similarity:	489/1424 - (34%)	Gaps:	464/1424 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LTTATTTASPSRSP-------EPEEEQPEEQSTSEQSIP-EQSTPDHQLENDIKSEAKSEIEPVE 121
            |.:..|::|.|.||       .|...:|........|:| |.|:|.| ..|.|.|.:.|
Zfish    38 LASEATSSSSSSSPTSLQDCQPPLAPRPSPGGLHAPSLPNESSSPPH-WPNHIASYSTS------ 95

  Fly   122 DNNNRVAMTKPSSEEREPNASGSM-PSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSS 185
                            .|||..|: |..|....|::    ..:|...::|...:...:|.
Zfish    96 ----------------LPNAHSSLSPDFPHPSLSSQ----THSPPPGQQKSTRISSHQPH----- 135

  Fly   186 AVPSTEVTLPGGAGAPVTLEAIQNMQMAIA---QFAAKTI-ANGSNGADNEAAMKQLAFLQQTLF 246
               ||..:.|.|..|..|..::.:.....|   |.:...| ...|:.::.......||.|.:.|.
Zfish   136 ---STVTSPPMGISATTTTSSLSSSSSLGAPPHQGSPSPIHQTPSSPSEQLQVPPTLAVLLEELR 197

  Fly   247 NLQQQQLFQIQLIQQLQSQ-LALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAE 310
            .|||:|:.|:|:.:::..| |.|.......|..:.:  .:.|:::..:......::...|..:|.
Zfish   198 VLQQRQIHQMQITEEICRQVLRLGGMVSAPDAPQGS--VEGQQRDAGSSSPPNGVSGASLINQAP 260

  Fly   311 ARMAEAKARQHLINAG-VPLRESSGSPAES----LKRRREHDHESQPNRRPSLDNTHKADTAQDA 370
            .    :|......|.| .|...:|.|.:.|    ......|.........|...|...|
Zfish   261 V----SKPNLSQTNGGRAPYSTTSSSTSSSSSLVTSTATVHPLSLTLGLPPRYLNEKSA------ 315

  Fly   371 LAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILANSMADDFAFG 435
                    |||:..|:.|      |....|.|..             |.||..|::|.....:.|
Zfish   316 --------NTPISHGNGL------NFQTSPLPTV-------------SISQDQLSHSSTVSTSNG 353

  Fly   436 EKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQR 500
             .|....||.:    |.||:||||..|||:||||:||||||||::|.||.|||||:||||.||.|
Zfish   354 -SSSSSSGRQQ----HICRFCGKVLSSDSSLQIHLRSHTGERPYQCPVCLSRFTTRGNLKAHFLR 413

  Fly   501 HAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSPA--------PPPLG-----SAPAS 552
            |.::.|.:.::..          ||.|.:.|.:.|....|..        ..|.|     ..|.|
Zfish   414 HREQNPELSLSLL----------PPALSEQSQSGSGSGGSQRRRKRRAEDEEPFGVKGSVGVPDS 468

  Fly   553 FP------PAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDEDEPQVKNEPVE 611
            ..      ||.|...:|..||...|..|..|.......:.........||.:......:.:..:
Zfish   469 LALGFLSGPAHPSPSSLPLPPSVDLALLSTAHSLLQLNRASAAAAASVSPSVQSSSSSITSSAM- 532

  Fly   612 EKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVK-QEDHRIEPRRTPSPSSEHRSPHH 675
                                                ..|:| .:..|.:....|.|:..|.|| :
Zfish   533 ------------------------------------TGQLKGSKQQRFDENTPPHPTLHHGSP-Y 560

  Fly   676 HRHSHMGYPPVVQPIQPA------ALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTT 734
            .:.:|:  |.::.|..|:      ||:.|          .||.:|            ..||.|..
Zfish   561 SQLAHL--PKILFPSGPSAHHPSLALLRP----------PHLTSP------------HLPLTFPF 601

  Fly   735 AKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALL---PRPHSND--- 793
            :....|::.|                ||...|...:.:...:.:: .:|..|   |.|.|.:
Zfish   602 SSYPKPQNSS----------------PPSSSPSSSSATSDTSKLQ-RLAQKLEKQPLPKSTNEGQ 649

  Fly   794 -NSWENFIEVSNTCETMKLKELM-------------KNKKISD-------PNQCVVCDRVLSCKS 837
             |:..|.|..|:...:...:|:|             .:::|..       ||||.||.|||||..
Zfish   650 TNTQANDISTSSNAISAYRREMMAALGLNPNPSSEPTSQEIQGSAASSLVPNQCGVCLRVLSCPR 714

  Fly   838 ALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPP-MRNFHQCPVCHKKYSNALVLQQ 901
            ||::|..||.|||||.|::|||:|:|||:|:.|:|.|:.||. .|..:.||:|.:|::||:|||.
Zfish   715 ALRLHQATHLGERPFPCKLCGRSFSTKGSLRAHLATHRARPANARGQNSCPLCQRKFTNAVVLQH 779

  Fly   902 HIRLHTGEPTDLTPE---QIQAAEIRDP------PPSM--MPGHFMNPFAAAAFHFGALPGGPGG 955
            |||:|.|  ..|.||   .:|:.:....      |.|:  :|.:.....||:....||:...|
Zfish   780 HIRMHLG--GQLPPEVNGDLQSEDAHSQIDGISLPKSLQSLPLNMSMSSAASLLDSGAILRDP-- 840

  Fly   956 PPGPNHGAHNGALGSESSQGDMDDNMDCGED-YDDDVSSEHLSNSNLEQEGDRSRSGDDF-KSLL 1018
                             :.||.|..|:..:| |::  :||:.....||:: |.||..... .|:.
Zfish   841 -----------------TSGDTDQLMESDQDPYEN--TSENSPTFTLEKQ-DPSRENSPLDNSVA 885

  Fly  1019 FEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQ----------------VI 1067
            .|:...:         .|....|...:|.:......|.|.....|||                ||
Zfish   886 LEENHYV---------TVHHSKSQVVNGSAHKDEDTPLSLCTRTSSQDPLFDKKWQNGASHHTVI 941

  Fly  1068 KRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLP 1132
               |.|..|.:|: ||||:|...|.||               |.|...|..||..:...:.
Zfish   942 ---SGPKPSLSSE-ALDLSPALTPPSS---------------PGLESKPDQSSEQTTLHVN---- 983

  Fly  1133 PTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKA 1197
               |||.:|     ..:....|           .|.::....::.|....:.::...|.|..:|.
Zfish   984 ---GIDHVP-----EFKDADSH-----------PAPENVIEHKLKADDTQESKMEESAVEDHKKD 1029

  Fly  1198 AAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCN 1262
            :......::.|       |.|:.||
Zfish  1030 SEKTEVTSSEA-------PVAQPQR---------------------------------------- 1047

  Fly  1263 AMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFT 1327
                                                              .|:|:.|:.|.:.:.
Zfish  1048 --------------------------------------------------SEKPYSCTECGKEYA 1062

  Fly  1328 TKGNLKQHMLTH------------------KIRD-MEQET---FRNRAVKYMSEWNEDR 1364
            ::..||.||..|                  |:.: ||:.|   .|....|.:||.:.|:
Zfish  1063 SRSGLKGHMKIHSGSMNQVAGTASSQSSGGKVAERMEESTHRKLRGEDAKNLSEESTDK 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	15/21 (71%)
		C2H2 Zn finger	453..473	CDD:275368	14/19 (74%)
		zf-H2C2_2	465..490	CDD:290200	18/24 (75%)
		C2H2 Zn finger	481..501	CDD:275368	14/19 (74%)
		C2H2 Zn finger	826..846	CDD:275368	11/19 (58%)
		zf-H2C2_2	838..863	CDD:290200	15/24 (63%)
		zf-C2H2_2	854..922	CDD:289522	33/71 (46%)
		C2H2 Zn finger	854..874	CDD:275368	11/19 (58%)
		C2H2 Zn finger	886..906	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1291..1311	CDD:275368	0/19 (0%)
		zf-H2C2_2	1303..1328	CDD:290200	4/24 (17%)
		C2H2 Zn finger	1319..1339	CDD:275368	6/19 (32%)
si:ch211-212k18.5	XP_021333427.1	EBV-NA3	<58..268	CDD:332796	50/250 (20%)
		C2H2 Zn finger	366..386	CDD:275368	14/19 (74%)
		zf-H2C2_2	378..403	CDD:316026	18/24 (75%)
		C2H2 Zn finger	394..414	CDD:275368	14/19 (74%)
		C2H2 Zn finger	703..723	CDD:275368	11/19 (58%)
		zf-H2C2_2	715..740	CDD:316026	15/24 (63%)
		C2H2 Zn finger	731..751	CDD:275368	11/19 (58%)
		C2H2 Zn finger	764..784	CDD:275368	12/19 (63%)
		C2H2 Zn finger	1054..1074	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020