DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sall1a

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001139486.1	Gene:	sall1a / 555721	ZFINID:	ZDB-GENE-020228-2	Length:	1313	Species:	Danio rerio

Alignment Length:	1363	Identity:	365/1363 - (26%)
Similarity:	526/1363 - (38%)	Gaps:	479/1363 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 TASPSRSP-EPEEEQPEEQSTSEQS----IPEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMT 130
            |.||..|| .|:|:..:..:.::|:    :.||:..|.  |..:.:|......|..|.|.|:|.:
Zfish    83 TFSPGSSPHNPDEQMNDTTNNTDQAELTDLLEQNILDK--EEAMDTEMSGVSAPHNDGNGRMAGS 145

  Fly   131 KPSS----EEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPSTE 191
            .|.|    ......::||...|.|..||..:...                            .||
Zfish   146 SPLSGVGTGHGTLGSTGSNLGSSVISASLPQLGN----------------------------LTE 182

  Fly   192 VTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQI 256
            :.......:.|.:|.:|:.::|:|||:.:|.|.|.......|.|:|       |..|||||:.|:
Zfish   183 LGNFSMINSNVIIENLQSTKVAVAQFSQETRATGGQRVAVPALMEQ-------LLALQQQQIHQL 240

  Fly   257 QLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQET------DTYEEEERIADMELRQKAEARMAE 315
            |||:|::.|:.|..::..|.....:.........|      .::..::..|...|.|...::.|.
Zfish   241 QLIEQIRHQILLLASQSPELQAPPSSSPVTLGSGTSPLTTLSSHLSQQLAAAAGLAQSIASQSAS 305

  Fly   316 AKARQHLIN-AGVPLRESS-GSPAESLKRRREHDHESQP---------NRRPSLDNTHKADTAQD 369
            ..:.:.:.| |.:|...|| |..::||.........:||         :..|.|.|...|.::..
Zfish   306 ISSLKQMANVAQLPQSNSSVGESSQSLAAPGPAPVNAQPLEKRPGNAGSLHPPLGNPSLAKSSTP 370

  Fly   370 ALAK---LKEMENTPLP--------FGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGI 423
            |.|.   |..:.||.||        |.|.| .|:.:..:||   |||..|.::.:....:.|
Zfish   371 AFAMGNLLNPVANTLLPQPPPGNPIFSSAL-PSVGSTVEDL---NSLAALAQQRKGKPPNVS--- 428

  Fly   424 LANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRF 488
                     :|..||..    .:.||||:||:||||||||||||||:||||||||:|||:||:||
Zfish   429 ---------SFEPKSSS----EDTFFKHKCRFCGKVFGSDSALQIHLRSHTGERPYKCNICGNRF 480

  Fly   489 TTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKF-----------HPPLLDQMSPTDSSPNHSPA 542
            :|:||||||||||.:|:||:.||..|:|||:|..           .||.....|..||.|..|..
Zfish   481 STRGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNIPTSTGIPYGMSMPPEKPVTSWLDSKPVLSTL 545

  Fly   543 PPPLGSAPASFPPAFPGLQNLYRPPM---EILKSLGAAAP-HQYFPQELPTD--LRKPSPQLDED 601
            ...:|..   .||..|.|     ||.   |...||..::| |.......|.|  ::.....|:|.
Zfish   546 TSSVGML---LPPTIPSL-----PPFIKKEENNSLAISSPSHSAKSDSGPADTPMKNTDSVLEEG 602

  Fly   602 EP---QVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRT 663
            |.   ...|...||.:|.......|:...|                           ..||...:
Zfish   603 ESTTLPTSNGKAEENNQSSNLLSNMSSAVE---------------------------GTIEYTTS 640

  Fly   664 PSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERF 728
            .||                 |....|:.|                              ..:|:|
Zfish   641 NSP-----------------PMATNPLMP------------------------------LMSEQF 658

  Fly   729 PLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSND 793
            ...|                |.||.|.|
Zfish   659 KAKF----------------PFGGLLDP------------------------------------- 670

  Fly   794 NSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRI 856
                  ::.|   ||.||::|::|  :|::|||:||:|.|:|||:|||:||||||||||||||::
Zfish   671 ------LQGS---ETSKLQQLVENIDRKVADPNECVICHRILSCQSALKMHYRTHTGERPFKCKV 726

  Fly   857 CGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAA 921
            ||||||||||||||.:||:..||:|..|.||:|.||::||:|||||||:|.|.....||
Zfish   727 CGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTP------ 785

  Fly   922 EIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDM----DDNMD 982
                     :|.::.....:.|..|                       .|.:..|:    ||||:
Zfish   786 ---------LPDNYPESMGSDAGSF-----------------------DERNIDDLDNFSDDNME 818

  Fly   983 CGEDYDD----------DVSSEHLSNS-----------NLEQEGDRSRSGDDFKSLLFEQKLRID 1026
            ..||..|          |.|.:.|.:|           .::::.....:|::.:   ::|...::
Zfish   819 GIEDGPDSSIPDTPKSVDASQDSLCSSPTLHESFGMDERIQEKSANHGAGEEVQ---YDQGKSVE 880

  Fly  1027 ATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAP 1091
             .|:|..:  |..:.:||.|..:.|.||                .|||.||
Zfish   881 -NGLVEGD--RFTNDSSSLGGDIESQSA----------------GSPAVSE-------------- 912

  Fly  1092 TSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLM 1156
             |:||.::|              |||..                                   :.
Zfish   913 -STSSMQAP--------------SPSNG-----------------------------------IF 927

  Fly  1157 QQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQ 1221
            |||                           :..:.|.:|:.|.:....:|:........|.|.|
Zfish   928 QQQ---------------------------KSPSMEDRQQRALSLEHISASLMHSNSASPGALD- 964

  Fly  1222 RQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVR 1286
                                                      :..:..|..|.:...|....|..
Zfish   965 ------------------------------------------LTSVNSSKDPISMLFPFRERGTL 987

  Fly  1287 GSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETF 1349
            .:|.|.||.|||.|.|||:||||||||||||.|::|:|||:||||||||||||::||:..:.|
Zfish   988 KNTACDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPSQLF 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	18/21 (86%)
		C2H2 Zn finger	453..473	CDD:275368	17/19 (89%)
		zf-H2C2_2	465..490	CDD:290200	20/24 (83%)
		C2H2 Zn finger	481..501	CDD:275368	15/19 (79%)
		C2H2 Zn finger	826..846	CDD:275368	14/19 (74%)
		zf-H2C2_2	838..863	CDD:290200	21/24 (88%)
		zf-C2H2_2	854..922	CDD:289522	39/67 (58%)
		C2H2 Zn finger	854..874	CDD:275368	15/19 (79%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	14/19 (74%)
		zf-H2C2_2	1303..1328	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1319..1339	CDD:275368	15/19 (79%)
sall1a	NP_001139486.1	ZnF_C2H2	443..465	CDD:197676	18/21 (86%)
		C2H2 Zn finger	445..465	CDD:275368	17/19 (89%)
		zf-H2C2_2	457..482	CDD:290200	20/24 (83%)
		C2H2 Zn finger	473..493	CDD:275368	15/19 (79%)
		C2H2 Zn finger	696..716	CDD:275368	14/19 (74%)
		zf-H2C2_2	708..733	CDD:290200	21/24 (88%)
		C2H2 Zn finger	724..744	CDD:275368	15/19 (79%)
		zf-C2H2	754..776	CDD:278523	15/21 (71%)
		C2H2 Zn finger	756..776	CDD:275368	14/19 (74%)
		C2H2 Zn finger	992..1012	CDD:275370	14/19 (74%)
		zf-H2C2_2	1004..1029	CDD:290200	19/24 (79%)
		zf-C2H2	1018..1040	CDD:278523	16/21 (76%)
		C2H2 Zn finger	1020..1040	CDD:275370	15/19 (79%)
		zf-C2H2	1123..1145	CDD:278523
		C2H2 Zn finger	1125..1145	CDD:275368
		zf-H2C2_2	1137..1162	CDD:290200
		C2H2 Zn finger	1153..1173	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11625
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	428	1.000	Inparanoid score	I1708
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	11	11.550