DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and Sall3

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_006255047.1	Gene:	Sall3 / 364910	RGDID:	1310232	Length:	1322	Species:	Rattus norvegicus

Alignment Length:	1404	Identity:	392/1404 - (27%)
Similarity:	537/1404 - (38%)	Gaps:	494/1404 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 EEEQPEEQSTSEQSIPEQSTPDHQLENDIKSEAKSEIEP--------------VEDNNNRVAMTK 131
            :||.|.:...||..:|.....|    .|..||::|..|.              .:...::...||
  Rat    15 DEELPPQDGASEHGVPGDGAED----ADSSSESRSGSEETSVCEKCCAEFFKWADFLQHKKTCTK 75

  Fly   132 --------------PSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVE-VDVE-KPD 180
                          ||.:..||:.:.|......:|.:.|.|..|.:..|...|:|| :||| ..|
  Rat    76 NPLVLIVHDDEPAPPSEDFPEPSPASSPSDRTESEVAEEVAPPEGSEVKAVAKEVEPMDVEASAD 140

  Fly   181 EA-PSSAVPSTEVTL-----PGGAGAP---VTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMK 236
            :. |..:||.....|     |.....|   ||||.:.:.::|:|||:....|.|:.||.......
  Rat   141 QGPPGPSVPPPPPALPPQPEPAAFSMPSTNVTLETLLSTKVAVAQFSQGARAGGTTGAGGSVGAV 205

  Fly   237 QLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIA 301
            .:..:.:.|..|||||:.|:|||:|::||:||                            ..|..
  Rat   206 AIPMILEQLVALQQQQIHQLQLIEQIRSQVAL----------------------------MSRQP 242

  Fly   302 DMELRQKAEARMAEAKARQHL-------INAGVPLRESSGSPAESLKRRREHDHESQP------- 352
            ...|:..|.|..|.:.....|       ::|| |...|:||.:..........|.|||
  Rat   243 GPPLKPSASAPGAASVQLPGLTPHASLQLSAG-PATASAGSGSTLSAAFDGPQHLSQPQPASGTS 306

  Fly   353 -----NRRPSLDNTHKA----------DTAQDALAKLKEMEN--TPLPFGSDLASSIITNHDDLP 400
                 :..|:....|.|          ..|...:....:.:|  ||...|   ...::::...||
  Rat   307 TPCSTSAGPTDSGAHPACSTGPAPGAVAAASSTVGNTVQPQNASTPPALG---PGPLLSSASSLP 368

  Fly   401 EPNSLDLLQKRAQEVLDSASQGILANSMA---------DDFAFGEKSGEGKGRN----------- 445
            .|    ||.:      .|:|..|..|.:.         |..:...|..:||..|
  Rat   369 SP----LLPQ------TSSSSVIFPNPLVSIAATANALDPLSALMKHRKGKPPNVSVFEPKASAE 423

  Fly   446 EPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPM 510
            :|||||:||:|.||||||||||||:||||||||||||:||:||:||||||||||||.:|:||:.|
  Rat   424 DPFFKHKCRFCAKVFGSDSALQIHLRSHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQM 488

  Fly   511 NATPIPEHMDKFHPPLLDQMSPTDSSPNHSP------APPPLGSAPAS----FPPAFPGLQNLYR 565
            |..|:||::|  :.|....:....|.|...|      :.|.|.:.|.|    .||..||..|...
  Rat   489 NPYPVPEYLD--NVPTCSGIPYGMSLPPEKPVTTWLDSKPVLPTVPTSVGLQLPPTVPGTHNYTD 551

  Fly   566 PPMEILKSLGAAAPHQYFPQELPTDLRKPSPQLDED---EPQVKNEPVEEKDQREEHEQEMAECS 627
            .|        :..|....||       :|||...|.   .|.:.|             .|.....
  Rat   552 SP--------SITPISRSPQ-------RPSPASSECTSLSPGLNN-------------TESGITV 588

  Fly   628 EPE-PEPL----PLEVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVV 687
            .|| |:||    ||.                   :.||...|..|           :..|..|||
  Rat   589 RPESPQPLLGGPPLT-------------------KAEPVSLPCTS-----------TRTGDAPVV 623

  Fly   688 QPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGG 752
            .. |.:.|..|.::..:.|....|.:|| ||...|.|..:||.                    ||
  Rat   624 GG-QVSGLPTPAATTVTDSACTSLGSPG-LPAVSDQFKAQFPF--------------------GG 666

  Fly   753 ALPPGVPPPPHHHPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN 817
            .|                                              :...|.||.||::|::|
  Rat   667 LL----------------------------------------------DSMQTSETSKLQQLVEN 685

  Fly   818 --KKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPM 880
              ||::||||||:|.|||||:|||:||||||||||||||:|||||||||||||||..||:.:||:
  Rat   686 IDKKMTDPNQCVICHRVLSCQSALKMHYRTHTGERPFKCKICGRAFTTKGNLKTHFGVHRAKPPL 750

  Fly   881 RNFHQCPVCHKKYSNALVLQQHIRLHTGE--PTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAA 943
            |..|.||:|.||::||:|||||||:|.|.  |....||.:|.|...:.|
  Rat   751 RVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTPLPEGLQEAMDAELP---------------- 799

  Fly   944 FHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDD-NMDCGEDYDDDVSSEHLSNSNLEQEGD- 1006
                                             .|: |.:....:||||     ..:::|::.:
  Rat   800 ---------------------------------FDEKNAETLSSFDDDV-----DENSMEEDSEL 826

  Fly  1007 RSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIK--- 1068
            :..:.|..|.||                             |...:..|:.|||.:|...::
  Rat   827 KDTASDSSKPLL-----------------------------SYSGSCPPSPPSVISSIAALENQM 862

  Fly  1069 ---------------RSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSG 1118
                           :|......|:.:.:.|.:.......|.|:.||...|...|....|...:|
  Rat   863 KMIDSVMNCQQLASLKSVENGSGESDRLSNDSSSAVGDLESRSAGSPALSESSSSQALSPAHSNG 927

  Fly  1119 SSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQ 1183
            .|..|.:                |||.|  |:..|.:
  Rat   928 ESFRSKS----------------PGLSH--QEDPQEI---------------------------- 946

  Fly  1184 EQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPN 1248
             .|:.|..:                     :||.        |||.|       ||.......|.
  Rat   947 -PLKTERLD---------------------SPPP--------GPGNG-------GALDLTAGHPG 974

  Fly  1249 LPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRG---STTCGICYKTFPCHSALEIHYRS 1310
            .||                   :...|||:.|.||..||   ||.||:|.|.|.|.|||||||||
  Rat   975 RPL-------------------IKEEAPFSLLFLSRERGKCASTVCGVCGKPFACKSALEIHYRS 1020

  Fly  1311 HTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETF 1349
            |||||||.|::|.||.:|.||||||:||||::::..:.|
  Rat  1021 HTKERPFVCTVCRRGCSTMGNLKQHLLTHKLKELPSQVF 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	15/19 (79%)
		zf-H2C2_2	838..863	CDD:290200	22/24 (92%)
		zf-C2H2_2	854..922	CDD:289522	42/69 (61%)
		C2H2 Zn finger	854..874	CDD:275368	16/19 (84%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	14/19 (74%)
		zf-H2C2_2	1303..1328	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1319..1339	CDD:275368	12/19 (63%)
Sall3	XP_006255047.1	COG5048	421..776	CDD:227381	185/482 (38%)
		C2H2 Zn finger	431..451	CDD:275368	16/19 (84%)
		zf-H2C2_2	443..468	CDD:290200	21/24 (88%)
		C2H2 Zn finger	459..479	CDD:275368	16/19 (84%)
		COG5048	670..1170	CDD:227381	178/575 (31%)
		C2H2 Zn finger	696..716	CDD:275368	15/19 (79%)
		zf-H2C2_2	708..733	CDD:290200	22/24 (92%)
		C2H2 Zn finger	724..744	CDD:275368	16/19 (84%)
		zf-C2H2	754..776	CDD:278523	15/21 (71%)
		C2H2 Zn finger	756..776	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1001..1021	CDD:275368	14/19 (74%)
		zf-H2C2_2	1013..1038	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1029..1049	CDD:275368	12/19 (63%)
		zf-C2H2	1135..1157	CDD:278523
		C2H2 Zn finger	1137..1157	CDD:275368
		zf-H2C2_2	1149..1174	CDD:290200
		C2H2 Zn finger	1165..1185	CDD:275368
		zf-C2H2	1165..1185	CDD:278523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11173
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1903
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930