DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and salr

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster

Alignment Length:	1352	Identity:	412/1352 - (30%)
Similarity:	581/1352 - (42%)	Gaps:	365/1352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SRSPEPEEEQPEEQSTSEQSIPEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREP 139
            :||...|.|:..::....         |...|.|..:....|::...:||.    |:|..|
  Fly    17 TRSGSGERERDRDRDRDR---------DRDRERDRDTLLAKELDADSNNNG----TEPQME---- 64

  Fly   140 NASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTL 204
              :.::|.|.....:|||...|:.||...|   .:|:.........::|        |:| .|:|
  Fly    65 --AEAVPESDTERETAEERGEEQEPENSNE---ALDLSLISSGGRESLP--------GSG-HVSL 115

  Fly   205 EAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQL--- 266
            ||:|:.::|:|||||..:|.....||       ||.:|.|:||:|:|.|.|:||||.|||||
  Fly   116 EALQHTKVAVAQFAATAMAGNHQSAD-------LAMVQSTIFNVQRQHLMQLQLIQHLQSQLKRA 173

  Fly   267 ---ALNQAKQEEDTEEDADQE-QDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHLINAGV 327
               ||.:....::.||:.:.| :.::|.|:..:||     :||.|..|:
  Fly   174 EAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEE-----LELEQGPES---------------- 217

  Fly   328 PLRESSGSPAESLKRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSI 392
                             |.|.||   ||.....|.|..| :|..|:.:..::......|.|||||
  Fly   218 -----------------EQDQES---RREENSKTDKRGT-EDRKAEPEGYQSMMCDISSSLASSI 261

  Fly   393 ITNHDDLP---EPNSLDLLQKRAQEVLDSASQGILANSMADDFA-FGEKSGEGKGRNEPFFKHRC 453
            |||||..|   |||.|::||:|.:||||||||.:.|..|.:::: :..|..:.:|.   .|||||
  Fly   262 ITNHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGE---IFKHRC 323

  Fly   454 RYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEH 518
            :||||:|||.||||||:|||||||||.||||||:||||||||||:|||.|.||
  Fly   324 KYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFP------------ 376

  Fly   519 MDKFHPPLLDQMSPTDSSPN--HSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAP-- 579
                 |.||    |...:||  ||......|.   .:|...|     :.||:         ||
  Fly   377 -----PMLL----PPGVAPNVGHSGQGQVQGE---QYPIRLP-----FAPPV---------APVG 415

  Fly   580 ---HQYFPQELPTDLRK--PSPQLDE-DEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEV 638
               ||...:| |.::|:  |.||.:: .:|.||                     |.|....|:
  Fly   416 QEQHQNQVEE-PEEIRQEIPVPQAEDLSKPMVK---------------------EKEKSHSPV-- 456

  Fly   639 RIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPG 703
                |||:..::||.:        ...||||  .|    ...:..|.|....:..::...|:|..
  Fly   457 ----ERVKTPKEVKTD--------AALPSSE--KP----EKEISKPVVTSSRRNGSVRKRQTSAV 503

  Fly   704 SQSHLDHLPTPGQLPPREDFFAER-FPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPH 767
            |             ||:||  .|| ...:...||::.....|....||..:|.
  Fly   504 S-------------PPQED--RERDLVEHLHIAKLVRRSSASRESQPAEYSLA------------ 541

  Fly   768 HMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCD 830
                         :|..::      |.|||:.||:..|.||.||::|:.|  .|::|||||:.|.
  Fly   542 -------------QMERII------DKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQ 587

  Fly   831 RVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSN 895
            :|:||:|:||||.|||||||||:|:||||||.||||||.||::|||:||||:..:|||||:|:||
  Fly   588 KVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSN 652

  Fly   896 ALVLQQHIRLHT--------GEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGG 952
            .::||||||:||        |.|. ..|.:.:...|.|...:...|      .:....|..
  Fly   653 GIILQQHIRIHTMDDGSGGQGAPA-ANPGEAERLGIEDQNSNKSLG------TSDTLDFST---- 706

  Fly   953 PGGPPGPNHGAHNGALGSESSQGDMDD--NMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFK 1015
                   ....|:|.....|..||.|:  .||..:|..|:.|:...:...||:|.||.:
  Fly   707 -------TISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREK------ 758

  Fly  1016 SLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQ 1080
                |::.||            |...:....||....:...|.|....:..:   |||:.:....
  Fly   759 ----ERERRI------------PNDCSDERSHSNPDLTGGRSESGEMPAMDL---SSPSSNSGRI 804

  Fly  1081 GALDLTPRAAPTSSSSSRSPLPKEKPVSPPSL--------PRSPSGSSHASANILT-SPL----- 1131
            .|..|...||  ...|....||......||:|        .....|.:||...:|. .||
  Fly   805 FATGLANGAA--GGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGL 867

  Fly  1132 --PPTVGIDC---LP--PGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMA-ALHQHQEQLRR 1188
              ||.|...|   ||  ..|:.|||.:|          |...|..|....|.: |...:..:|..
  Fly   868 HPPPNVCNLCFKMLPSLAALESHLQSEH----------AKEPATGHAQRPQCSDAGSPYGAKLTL 922

  Fly  1189 EAAEAQQKAAAAAAAAAAAAAAQRQTPP------------QARDQRQ----EG-----GPGAGPP 1232
            ......:|..:::::::.....:...||            :..||.|    ||     |.|.|..
  Fly   923 NPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGAT 987

  Fly  1233 PN----------PLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRG 1287
            .|          .||..:.....||..||              ...|::|.|.|........|..
  Fly   988 SNYPQEAGDAEQSLMKMQLHAHRFPASPL--------------DFQQALMSAGPPTSSLDPPVNN 1038

  Fly  1288 STTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            ...|.:|.:.|...|||:||.|:||.::||:|::|.:.||||||||.||.||
  Fly  1039 KHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	15/19 (79%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	17/19 (89%)
		C2H2 Zn finger	826..846	CDD:275368	11/19 (58%)
		zf-H2C2_2	838..863	CDD:290200	20/24 (83%)
		zf-C2H2_2	854..922	CDD:289522	41/75 (55%)
		C2H2 Zn finger	854..874	CDD:275368	15/19 (79%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	9/19 (47%)
		zf-H2C2_2	1303..1328	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1319..1339	CDD:275368	12/19 (63%)
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	17/21 (81%)
		C2H2 Zn finger	323..343	CDD:275368	15/19 (79%)
		zf-H2C2_2	335..360	CDD:290200	21/24 (88%)
		C2H2 Zn finger	351..371	CDD:275368	17/19 (89%)
		C2H2 Zn finger	583..603	CDD:275368	11/19 (58%)
		zf-H2C2_2	595..620	CDD:290200	20/24 (83%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	14/19 (74%)
		lambda-1	1013..>1061	CDD:212564	15/61 (25%)
		zf-C2H2	1040..1062	CDD:278523	9/21 (43%)
		C2H2 Zn finger	1042..1062	CDD:275368	9/19 (47%)
		zf-H2C2_2	1054..1079	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1070..1090	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468523
Domainoid	1	1.000	47	1.000	Domainoid score	I12034
eggNOG	1	0.900	-	-		E1_KOG1074
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5659
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm14690
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
	10	9.800