DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and Sall1

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001100885.2	Gene:	Sall1 / 307740	RGDID:	1309916	Length:	1315	Species:	Rattus norvegicus

Alignment Length:	1424	Identity:	370/1424 - (25%)
Similarity:	556/1424 - (39%)	Gaps:	489/1424 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KQLKDRARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQ-----------------PE 86
            ||.|.:...:|.::.|....:|.       |....|||..:.::..                 .:
  Rat     5 KQAKPQHFQSDPEVASLPRRDGD-------TEKGQPSRPTKSKDAHVCGRCCAEFFELSDLLLHK 62

  Fly    87 EQSTSEQSI------------------PEQSTPDHQLENDIKSEAKSEIEPVEDNNNRVAMTKPS 133
            :..|..|.:                  |..:.||.|::   ...:|::.|...|.:....:.:..
  Rat    63 KSCTKNQLVLIVNESPASPPKTFPPGPPSLNNPDEQMK---FVASKADQEDCGDLSEHKGLDREE 124

  Fly   134 SEERE-PNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVPST-----EV 192
            |.|.| |.|:.|..|:....:|....||.             .........:||:.::     ::
  Rat   125 SMETEVPVATSSSSSNGGTLSSVTNIATP-------------SCHSGSSTGTSAITTSLPQLGDL 176

  Fly   193 TLPGG---AGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQTLFNLQQQQLF 254
            |..|.   ..:.|.:|.:|:.::|:|||:.:....|::|     ....::.|.:.|..|||||:.
  Rat   177 TTLGNFSVINSNVIIENLQSTKVAVAQFSQEARCGGASG-----GKLLISALMEQLLALQQQQIH 236

  Fly   255 QIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQET-------DTYEEEERIADMELRQKAEAR 312
            |:|||:|::.|:.| .|.|..|....:...|...:.:       .::..::......|.|...::
  Rat   237 QLQLIEQIRHQILL-LASQNADLSASSVPSQGTLRTSANPLTTLSSHLSQQLAVAAGLAQSLASQ 300

  Fly   313 MAEAKARQHL-------INAGVPLRESSG-SP-------------AESLKRRREHDHESQPNRRP 356
            .|.....:.|       .::|..:..||| ||             :|.:.......|.|.|....
  Rat   301 SANISGVKQLPPVQLPQSSSGTIIPPSSGPSPNVSMVTATVPTPSSEKVASNAGASHVSPPAVSA 365

  Fly   357 SLDNTHKADTAQDALAKLKEMEN---------------TPLPFGSDLASSIITNHDDLPEPNSLD 406
            |      :..|..|::.|....:               ||||       :|.|..:||   |:|.
  Rat   366 S------SSPAAFAISSLLSPASNPLLPQPTPANAVFPTPLP-------NIATTAEDL---NALS 414

  Fly   407 LLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIR 471
            .|.::.:....:.:            ||..||..    :|.||||:||:|.||||||||||||:|
  Rat   415 ALAQQRKSKPPNVT------------AFEAKSTS----DEAFFKHKCRFCAKVFGSDSALQIHLR 463

  Fly   472 SHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSS 536
            |||||||||||:||:||:||||||||||||.:|:||:.||..|:|||:|..         ||.:.
  Rat   464 SHTGERPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNV---------PTSTG 519

  Fly   537 PNHSPAPPPLGSAPASFPPAFPGLQNLYRPPM--EILKSLGAAAPHQYFPQELPTDLRKPSPQLD 599
                   .|.|   .|.||..|....|...|:  .:..|:|...|                |.|.
  Rat   520 -------IPYG---MSIPPEKPVTSWLDTKPVLPTLTTSVGLPLP----------------PTLP 558

  Fly   600 EDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEPRRTP 664
            ...|.:|.|                     ||.|:|    |.......|..||.:        :.
  Rat   559 SLTPFIKTE---------------------EPAPIP----ISHSAASPQGSVKSD--------SG 590

  Fly   665 SPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSH-LDHLPTPGQLPPREDFFAERF 728
            :|....|:|       .|.|...:    .:.:.|....|..|. :..:||.|
  Rat   591 APDLATRNP-------SGVPEEAE----GSAVPPFGGKGEDSSVVSSIPTAG------------- 631

  Fly   729 PLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPI----KHEMAALLPRP 789
                      |...:|||..  |||                ..:.|.||:    ..:..|..|
  Rat   632 ----------SSALNSPVAD--GGA----------------GGTTFTNPLLPLMSEQFKAKFP-- 666

  Fly   790 HSNDNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMHYRTHTGERPF 852
                  :...::.:...||.||::|::|  ||.:|||:||:|.|||||:|||:||||||||||||
  Rat   667 ------FGGLLDSAQASETSKLQQLVENIDKKATDPNECVICHRVLSCQSALKMHYRTHTGERPF 725

  Fly   853 KCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQ 917
            ||:|||||||||||||||.:||:..||:|..|.||:|.||::||:|||||||:|.|.....||
  Rat   726 KCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHMGGQIPNTP-- 788

  Fly   918 IQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMD 982
                 :.|..|..|                                       ||..|..|:
  Rat   789 -----VPDNYPESM---------------------------------------ESDTGSFDE--- 806

  Fly   983 CGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGH 1047
              :::||   .::.|:.|:|
  Rat   807 --KNFDD---LDNFSDENME--------------------------------------------- 821

  Fly  1048 SVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSS-SRSPLPKEKPVSPPS 1111
                                         |..:|::..||::|..|..| |.||||.|.
  Rat   822 -----------------------------ECPEGSIPDTPKSADASQDSLSSSPLPLEM------ 851

  Fly  1112 LPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQM 1176
                   ||.|:                    |::.::..:..|.:|   :.|:..:..:...:.
  Rat   852 -------SSIAA--------------------LENQMKMINAGLAEQ---LQASLKSVENGSVEG 886

  Fly  1177 AALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTP----------PQARDQRQEGGPGA-- 1229
            ..|......:   ..:.:.:::.:.|.:.:.::.|..:|          |...::.|..|||.
  Rat   887 DVLTNDSSSV---GGDVESQSSGSPAISESTSSMQALSPSNSTQEFHKSPNVEEKPQRVGPGEFA 948

  Fly  1230 -GPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRG---STT 1290
             |..|.|:.|..        |.|    |:.:....:.:.:..::  .||..      ||   :|.
  Rat   949 NGLSPTPVNGGA--------LDL----TSSHAEKIIKEDSLGIL--FPFRD------RGKFKNTA 993

  Fly  1291 CGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQETF 1349
            |.||.|||.|.|||:||||||||||||.|::|.|||:||||||||||||::||:..:.|
  Rat   994 CDICGKTFACQSALDIHYRSHTKERPFICTVCSRGFSTKGNLKQHMLTHQMRDLPSQLF 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	15/19 (79%)
		zf-H2C2_2	838..863	CDD:290200	22/24 (92%)
		zf-C2H2_2	854..922	CDD:289522	40/67 (60%)
		C2H2 Zn finger	854..874	CDD:275368	16/19 (84%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	14/19 (74%)
		zf-H2C2_2	1303..1328	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1319..1339	CDD:275368	15/19 (79%)
Sall1	NP_001100885.2	C2H2 Zn finger	445..465	CDD:275368	16/19 (84%)
		zf-H2C2_2	457..482	CDD:290200	21/24 (88%)
		C2H2 Zn finger	473..493	CDD:275368	16/19 (84%)
		COG5048	692..1160	CDD:227381	163/548 (30%)
		C2H2 Zn finger	699..719	CDD:275368	15/19 (79%)
		zf-H2C2_2	711..736	CDD:290200	22/24 (92%)
		C2H2 Zn finger	727..747	CDD:275368	16/19 (84%)
		zf-C2H2	757..779	CDD:278523	15/21 (71%)
		C2H2 Zn finger	759..779	CDD:275368	14/19 (74%)
		C2H2 Zn finger	994..1014	CDD:275370	14/19 (74%)
		zf-H2C2_2	1006..1031	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1022..1042	CDD:275370	15/19 (79%)
		lambda-1	1055..>1146	CDD:212564
		zf-C2H2	1125..1147	CDD:278523
		C2H2 Zn finger	1127..1147	CDD:275368
		zf-H2C2_2	1139..1164	CDD:290200
		C2H2 Zn finger	1155..1175	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11173
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.970