DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salm and SPAC25B8.19c

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_594479.2	Gene:	SPAC25B8.19c / 2542738	PomBaseID:	SPAC25B8.19c	Length:	522	Species:	Schizosaccharomyces pombe

Alignment Length:	503	Identity:	111/503 - (22%)
Similarity:	169/503 - (33%)	Gaps:	116/503 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 TATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPDHQLENDIKS--------EAKSEIEPVEDN 123
            |.:.:|:.|| |.|....|    ....:.|..|..:..|||::.|        .|..::|.....
pombe    66 TVSESANVSR-PTPAPVPP----AGNTNTPTTSNSNQNLENNVTSAASMPAILNAAGQLEFSPST 125

  Fly   124 NNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEKDVEVDVEKPDEAPSSAVP 188
            ||  |:...::....|:    ||.:.:|.:||.    .|.|                  |.|
pombe   126 NN--ALCCCTTVHGHPH----MPPNLLAASSAR----LRLP------------------PIS--- 159

  Fly   189 STEVTLPGGAGAPVTLEAIQNMQMAIAQFA------AKTIANGSNGADNEAA-----MKQLAFLQ 242
                |:.||..|..|..|.. ...|:..:|      |...:|.|||..|.||     :...:.|.
pombe   160 ----TILGGTFADPTFLAAA-AAAAVPHYAHATTGSATDASNTSNGNSNPAAVPAGFLSGYSPLS 219

  Fly   243 QTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQ 307
            ...|..:..:|   .|..|.||..|..|...:.:| ..|:......||..:.........:..:|
pombe   220 YAYFVAKANEL---ALANQRQSSEAAEQPSSKNNT-SGANPPSSNNQEVTSAPIPAAPIVLPFQQ 280

  Fly   308 KAEARM----AEAKARQHLINAGVPLRESSGSPAESLKRRREH---DHESQPNRRPSLDNT---- 361
            .....:    |:....||:   .||..........|.:..:.|   |.....:..|...||
pombe   281 PFYPIVCPGCAQGALPQHI---PVPHNTEFAQYQPSSRDLQNHPTVDESRLSSVAPPASNTLNHA 342

  Fly   362 --HKADTAQDALAKLKE----MENTPLPFGSDLASSIITNH-----DDLPEPNSLDLLQKRAQEV 415
              ::|:.|.::......    ..||..|....|.:....||     ..:|..|..|.:......|
pombe   343 NGNQAENASESSTSQSNDSQGPANTSYPVSVPLPNDAENNHTLSRNPYIPSLNFKDNMSAELSVV 407

  Fly   416 LDSASQGILANSMA-------DDFAFGEK------------------SGEGKGRNEPFFKHRCRY 455
            ...||....|:.|.       .|....:|                  :|.....:....::||..
pombe   408 ATLASNSAQAHPMGQQSDSNYSDHHNNDKRAHVSRRHSTSRKIAQSHTGSSSTSSAANVRYRCTE 472

  Fly   456 CGKVFGSDSALQIHIRSHTGERPFKCNV--CGSRFTTKGNLKVHFQRH 501
            |.:.|...|:|:||..||||||||.|:.  ||..|..:.|::.|.:.|
pombe   473 CLQGFSRPSSLKIHTYSHTGERPFVCDYAGCGKAFNVRSNMRRHQRIH 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	8/21 (38%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	15/26 (58%)
		C2H2 Zn finger	481..501	CDD:275368	6/21 (29%)
		C2H2 Zn finger	826..846	CDD:275368
		zf-H2C2_2	838..863	CDD:290200
		zf-C2H2_2	854..922	CDD:289522
		C2H2 Zn finger	854..874	CDD:275368
		C2H2 Zn finger	886..906	CDD:275368
		C2H2 Zn finger	1291..1311	CDD:275368
		zf-H2C2_2	1303..1328	CDD:290200
		C2H2 Zn finger	1319..1339	CDD:275368
SPAC25B8.19c	NP_594479.2	C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..508	CDD:290200	14/25 (56%)
		C2H2 Zn finger	498..520	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030