DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and Zfp62

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001349654.1	Gene:	Zfp62 / 22720	MGIID:	99662	Length:	914	Species:	Mus musculus

Alignment Length:	1117	Identity:	184/1117 - (16%)
Similarity:	319/1117 - (28%)	Gaps:	404/1117 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 NQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQKAEARMAEAKARQHLINAGVPLRESS 333
            |...|...||.:..::.:..:..:.......|||.:|.:..|.
Mouse    94 NTMHQTIPTEPNCTKQGEHTENINGNVHPAHIADKKLHKCDEC---------------------- 136

  Fly   334 GSPAESLKRRREHDHESQPNRRPSLDNTHKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDD 398
            |...:...|..:|.......:|...|:......:..:|...|.:.....|:..|.......::..
Mouse   137 GKSFKYNSRLVQHKIMHTGEKRYECDDCRGTFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSYSS 201

  Fly   399 LPEPNSLDLLQKRAQEVLDSASQGILANSMADD---FAFGEKSGEGKGRNEPFFKHRCRYCGKVF 460
            |....|....:|..:  .|...:....:|:.|.   ...|||            .:.|..|||.|
Mouse   202 LINHKSTHSGEKNCK--CDECGKSFNYSSVLDQHKRIHTGEK------------PYECGECGKAF 252

  Fly   461 GSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPP 525
            .:.|.|::|.|.||||:|::|:.||..|:....|:||.:.|..:.|:.
Mouse   253 RNSSGLRVHKRIHTGEKPYECDTCGKTFSNSSGLRVHKRIHTGEKPYE----------------- 300

  Fly   526 LLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTD 590
             .|:..                       .||...:.|...     ||:       :|
Mouse   301 -CDECG-----------------------KAFITCRTLLNH-----KSI-------HF------- 322

  Fly   591 LRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQED 655
                     .|:|.                    :|.|.|.......:.|:.:.:...|:..:.|
Mouse   323 ---------GDKPY--------------------KCDECEKSFNYSSLLIQHKVIHTGEKPYECD 358

  Fly   656 HRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPPR 720
            ...:..|..|....|:..|                                       .|:.|.:
Mouse   359 ECGKAFRNSSGLIVHKRIH---------------------------------------TGEKPYK 384

  Fly   721 EDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIKHEMAAL 785
            .|...:.|  ::::...:....|               |....|......:|..:|.:
Mouse   385 CDICGKAF--SYSSGLAVHKSIH---------------PGKKAHECKDCGKSFSYNSL------- 425

  Fly   786 LPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKI---SDPNQCVVCDRVLSCKSALQMHYRTHT 847
                                        |:::|.|   ..|..|.||.:.....|.|::|.|.||
Mouse   426 ----------------------------LLQHKTIHTGERPYVCDVCGKTFRNNSGLKVHRRLHT 462

  Fly   848 GERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHTGEPTD 912
            ||:|:||.:||:|:.::.:||.|..:|....|    ::|..|.|.::.:..|:||.|:||.|
Mouse   463 GEKPYKCDVCGKAYISRSSLKNHKGIHMGEKP----YKCSYCEKSFNYSSALEQHKRIHTRE--- 520

  Fly   913 LTPEQIQAAEIRDPPPSMMPGHFMNPF----AAAAFHFGALPGGPGGPPGPNHG------AHNGA 967
                                    .||    ...||.             .|.|      .|.|.
Mouse   521 ------------------------KPFGCDECGKAFR-------------NNSGLKVHKRIHTGE 548

  Fly   968 LGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDD-------FKSLLFEQKLRI 1025
            ...:..        :||:.|   :|...|.|......|::....|:       :::||..:|:.:
Mouse   549 RPYKCE--------ECGKAY---ISLSSLINHKSVHPGEKPFKCDECEKAFITYRTLLNHKKIHL 602

  Fly  1026 DATGVVNTNPVR--------PRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSS-PARSEASQG 1081
                  ...|.:        ..:|..|....|.:...|.  ......:|.:.:|| ........|
Mouse   603 ------GEKPYKCDVCEKSFNYTSLLSQHKRVHTREKPF--ECDRCEKVFRNNSSLKVHKRIHTG 659

  Fly  1082 ----ALDLTPRAAPTSSSSSRSPLPKEKPVSP--PSLPRSPSGSSHASANILTSPLPPTVG---- 1136
                ..|:..:|     ..|.|.|...|...|  .|......|.:..|:..|.|.....:|
Mouse   660 EKPYECDICGKA-----YISHSSLINHKSTHPGKTSYTCDECGKAFFSSRTLISHKRVHLGEKPF 719

  Fly  1137 --IDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAA 1199
              ::|........|..||:.:...:.........:...:.....:|:.
Mouse   720 KCVECGKSFSYSSLLSQHKRIHTGEKPYVCDWCGKAFRNSSGLTVHKR----------------- 767

  Fly  1200 AAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAM 1264
                                                :.....|:|                |:..
Mouse   768 ------------------------------------IHTGEKPYG----------------CDEC 780

  Fly  1265 NQ--IAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFT 1327
            .:  |:.|.:    .|..::...:....|. |.|:|...|.|:.|.|.||.::|::|:.|.:.|.
Mouse   781 EKAYISHSSL----INHKSVHRGKQPYNCE-CGKSFNYRSVLDQHKRIHTGKKPYRCNDCGKAFN 840

  Fly  1328 TKGNLKQHMLTH 1339
            .:.||.:|...|
Mouse   841 IRSNLTKHKRIH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	9/21 (43%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	826..846	CDD:275368	7/19 (37%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	19/67 (28%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1319..1339	CDD:275368	6/19 (32%)
Zfp62	NP_001349654.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..101		2/6 (33%)
		COG5048	127..542	CDD:227381	114/674 (17%)
		C2H2 Zn finger	133..153	CDD:275368	4/41 (10%)
		C2H2 Zn finger	161..181	CDD:275368	3/19 (16%)
		C2H2 Zn finger	189..209	CDD:275368	3/19 (16%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		C2H2 Zn finger	245..265	CDD:275368	9/19 (47%)
		C2H2 Zn finger	273..293	CDD:275368	7/19 (37%)
		C2H2 Zn finger	301..321	CDD:275368	6/54 (11%)
		C2H2 Zn finger	329..349	CDD:275368	4/19 (21%)
		C2H2 Zn finger	357..377	CDD:275368	4/19 (21%)
		SFP1	<379..458	CDD:227516	18/130 (14%)
		C2H2 Zn finger	385..405	CDD:275368	2/21 (10%)
		C2H2 Zn finger	413..433	CDD:275368	4/54 (7%)
		COG5048	437..850	CDD:227381	102/554 (18%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		C2H2 Zn finger	525..545	CDD:275368	4/32 (13%)
		C2H2 Zn finger	553..573	CDD:275368	6/30 (20%)
		C2H2 Zn finger	581..601	CDD:275368	4/19 (21%)
		C2H2 Zn finger	609..629	CDD:275368	2/19 (11%)
		C2H2 Zn finger	637..657	CDD:275368	3/19 (16%)
		C2H2 Zn finger	665..685	CDD:275368	6/24 (25%)
		C2H2 Zn finger	693..713	CDD:275368	4/19 (21%)
		C2H2 Zn finger	721..741	CDD:275368	4/19 (21%)
		C2H2 Zn finger	749..769	CDD:275368	1/72 (1%)
		C2H2 Zn finger	777..797	CDD:275368	4/23 (17%)
		C2H2 Zn finger	805..824	CDD:275368	8/19 (42%)
		C2H2 Zn finger	832..852	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000