DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and Zfp26

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	1373	Identity:	236/1373 - (17%)
Similarity:	385/1373 - (28%)	Gaps:	572/1373 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LKDRARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPDHQL 105
            |.|..::.:||..:.|:|....|  ....||.:|:::.:|.....||. ||..::        :|
Mouse    30 LADCLKNCNKDFVTFQDEAVDFS--EEEWTTKAPTQNSKPGAVAVEEH-TSLAAV--------EL 83

  Fly   106 ENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASGSMPSSPVAEASAEEAATERTPEKEKEK 170
            |..::::   ::.|.:|...|...               |.:..|...:.|:.|.:.|.|:....
Mouse    84 EKQLQTK---DLAPEQDFLTRHTF---------------METQQVDAVTFEDVAVDFTQEEWTSL 130

  Fly   171 D-VEVDVEKPDEAPSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAA 234
            | |:.::.:                      .|.||..||:         .|:..
Mouse   131 DPVQRNLYR----------------------DVMLENYQNL---------ATVGG---------- 154

  Fly   235 MKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEER 299
                             |:|:..||..|:.::.|...            ||...||.:.:.:.:|
Mouse   155 -----------------QMFKPSLISWLEKKVELTVI------------EQGILQEWEMHLKTKR 190

  Fly   300 IADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDHESQPNRRPSLDNTH-- 362
            .|..:.|..::........|:|          |.|.|.:.::.......:|.|....|..||.
Mouse   191 TALQQDRFWSDMSNGMQLGREH----------SGGEPGDPVQVGAVFSEDSCPQTHSSTSNTGNT 245

  Fly   363 --------------KADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEP----------- 402
                          |..:.::.:.:|.:... ||.|..|::....|     ||.
Mouse   246 FACNLDGKDFQPLLKETSTEENIVQLNQCVK-PLIFTPDVSQKKCT-----PEKSVECSDCGETF 304

  Fly   403 -NSLDLLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGK-------GRNEPFFK--HRCRYCG 457
             |.|:|             |...::....:....|:.|:..       |...|..|  :.|:.|.
Mouse   305 VNQLEL-------------QTHSSSHREKNIHKSEECGQASTHPISHGGHVIPTEKKYYECKKCE 356

  Fly   458 KVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKF 522
            |.|.....|.||::|||.|:|:.|..||..||.:.:|.||.::|.:
Mouse   357 KFFTHPVYLNIHMQSHTVEKPYDCKECGKAFTERSSLIVHLRQHTR------------------- 402

  Fly   523 HPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQEL 587

Mouse   403 ----------------------------------------------------------------- 402

  Fly   588 PTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVK 652
                                          |...|..||.:...:|..|...::....|:..|..
Mouse   403 ------------------------------EKSYECKECGKTFIQPSRLTEHMRSHTGEKPYQCD 437

  Fly   653 QEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQL 717
            |..:..       .||.:.:.  |..:|.|..|....|...|...      |...|.|:.|....
Mouse   438 QCGNAF-------ASSSYLTT--HLRTHTGEKPFECNICGKAFTR------SSYLLGHIRTHTGE 487

  Fly   718 PPRE-----DFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNP 777
            .|.|     ..|:.|..|..                               |...|....|:
Mouse   488 KPYECKVCGKAFSGRSWLTI-------------------------------HLRKHTGERPY--- 518

  Fly   778 IKHEMAALLPRPHSN-DNSWENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCKSALQM 841
                       |.:. :.::.:|.:         |.|.:|......|.:|.||.|.....|.|:.
Mouse   519 -----------PCTECEKAFTSFAQ---------LTEHIKTHTGEKPFRCKVCARTFRNSSCLKT 563

  Fly   842 HYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLH 906
            |:|.|||.:|:||..||:|||.:..|..|:.:|....|    ::|..|.|.:|.:..|.:|||:|
Mouse   564 HFRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNGEKP----YECKECGKAFSTSSGLVEHIRIH 624

  Fly   907 TGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPF-----AAAAFHFGALPGGPGGPPGPNHGAHNG 966
            |||                           .||     ..|..|..:|.|        :...|.|
Mouse   625 TGE---------------------------KPFECYQCGKALAHSSSLVG--------HLRTHTG 654

  Fly   967 ALGSESSQGDMD--------------------DNMDCGEDYDD-DVSSEHLSNSNLEQEGDRSRS 1010
            ....|.:|.|..                    :..:||:.:.: ...::|:.....|:..:....
Mouse   655 EKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKEC 719

  Fly  1011 GDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRS----S 1071
            |..|.|  |.| |.:......:..|.:.:....|..:   |:|..|...:|...:..|.|    :
Mouse   720 GKGFIS--FAQ-LTVHIKTHSSERPFQCKVCTKSFRN---SSSLETHFRIHTGVKPYKCSYCGKA 778

  Fly  1072 SPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVG 1136
            ..|||
Mouse   779 FTARS------------------------------------------------------------ 783

  Fly  1137 IDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAA 1201
                  ||..||:   .|..::..|......|.......:|.:..|:.:   :..|......|.|
Mouse   784 ------GLTIHLR---NHTGEKSYACQECGKAFSTSSGLIAHIRSHKGE---KPFECDHCGKAFA 836

  Fly  1202 AAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQ 1266
            :::......:..|                       |.:|
Mouse   837 SSSYLNVHLKIHT-----------------------GEKP------------------------- 853

  Fly  1267 IAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGN 1331
                                  ..|.:|.|||.|.|.|.:|.|:||.|:||:|.||.:.|.....
Mouse   854 ----------------------FQCTVCGKTFTCSSYLPVHMRTHTGEKPFQCIICGKSFLWSSY 896

  Fly  1332 LKQHMLTH 1339
            |:.||..|
Mouse   897 LRVHMRIH 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	7/21 (33%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	826..846	CDD:275368	8/19 (42%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	22/67 (33%)
		C2H2 Zn finger	854..874	CDD:275368	8/19 (42%)
		C2H2 Zn finger	886..906	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1291..1311	CDD:275368	10/19 (53%)
		zf-H2C2_2	1303..1328	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1319..1339	CDD:275368	7/19 (37%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630	17/115 (15%)
		C2H2 Zn finger	297..317	CDD:275368	4/32 (13%)
		COG5048	325..760	CDD:227381	121/662 (18%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	380..400	CDD:275368	8/19 (42%)
		C2H2 Zn finger	408..428	CDD:275368	4/19 (21%)
		C2H2 Zn finger	436..456	CDD:275368	4/28 (14%)
		C2H2 Zn finger	464..484	CDD:275368	5/25 (20%)
		C2H2 Zn finger	492..512	CDD:275368	4/50 (8%)
		C2H2 Zn finger	520..540	CDD:275368	4/28 (14%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	8/19 (42%)
		COG5048	600..956	CDD:227381	83/492 (17%)
		C2H2 Zn finger	604..624	CDD:275368	8/19 (42%)
		C2H2 Zn finger	632..652	CDD:275368	4/27 (15%)
		C2H2 Zn finger	660..680	CDD:275368	2/19 (11%)
		C2H2 Zn finger	688..708	CDD:275368	3/19 (16%)
		C2H2 Zn finger	716..736	CDD:275368	6/22 (27%)
		C2H2 Zn finger	744..764	CDD:275368	4/22 (18%)
		C2H2 Zn finger	772..792	CDD:275368	8/88 (9%)
		C2H2 Zn finger	800..820	CDD:275368	2/19 (11%)
		C2H2 Zn finger	828..848	CDD:275368	2/19 (11%)
		C2H2 Zn finger	856..876	CDD:275368	10/19 (53%)
		C2H2 Zn finger	884..904	CDD:275368	7/19 (37%)
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000