DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and Zfp658

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001008549.1	Gene:	Zfp658 / 210104	MGIID:	2652821	Length:	887	Species:	Mus musculus

Alignment Length:	1245	Identity:	232/1245 - (18%)
Similarity:	333/1245 - (26%)	Gaps:	591/1245 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 QEQDQEQE---------TDTYEEEERIADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAE 338
            |||:..:|         .|..:||.|..|...|...:..|.|..:  ||:..|.|:    .||..
Mouse    13 QEQEGSRERLVSFEDVTVDFSQEEWRRLDSVQRHLYQDVMLEIYS--HLLAVGYPV----PSPGA 71

  Fly   339 --SLKRRRE--------------HDHESQ---PNRRPSLD---NTHKA----------------- 364
              .:|:|:|              .:.||:   |.::.|.:   .|.||
Mouse    72 IFRIKKRKEARTGEAKLPHPCWCQEVESEFYRPQQKASEEAAFQTSKASAVTRHGLWCSILEELW 136

  Fly   365 ---DTAQ-----------------------DALAKLKEMENTPLPFGSDLASS------------ 391
               |.||                       |.....||...| .||.::|.|:
Mouse   137 QDPDPAQRDGQNQIPPWSPGASLNKKTARADRDCGWKEPGKT-TPFVANLFSTQKGAPRLLAKRL 200

  Fly   392 --------------------IITNHDDLPE-------------------------PNSLDLLQKR 411
                                ::|:...||:                         |....|.:|.
Mouse   201 NPNLEANGEEQGSVTKQLNGLVTSAHLLPQDSSNANCTILRETWNPCKGNQCRKVPTHKQLTEKE 265

  Fly   412 A--QEVLDSASQGILANSMADDFAF--------GE------KSGEGKGRNEPFFKHR-------- 452
            |  :|.||..::  ......|:.||        ||      |.||...:...|..|:
Mouse   266 AHSREKLDEGTE--CRKVFYDESAFCKHQAAHAGEGPFVCHKCGEAFLQKTEFASHQETHPEKPY 328

  Fly   453 -CRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIP 516
             |..|||.|...|.||:|.|.||||:|::|..||..|.....||||::.|..:.|:|
Mouse   329 ECPDCGKSFSRTSNLQVHHRIHTGEKPYECRDCGKSFNNTSQLKVHYRIHTGERPYV-------- 385

  Fly   517 EHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQ 581
                                      .|..|.|                     .|.....:.|
Mouse   386 --------------------------CPVCGKA---------------------FKQKSILSTH- 402

  Fly   582 YFPQELPTDLRKP-----SPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIK 641
               :.:.|. .||     ..:|.....::|   |..:...:|...|..:|.:.......|.|.
Mouse   403 ---ETIHTG-EKPYKCTVCGKLFSCTSRLK---VHYQIHMKEKPYECGDCGKAFKRKSSLTVH-- 458

  Fly   642 EERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQS 706
                          .:|..|:|           ||..|..|
Mouse   459 --------------QKIHIRQT-----------HHECSECG------------------------ 474

  Fly   707 HLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMAR 771
                                   ..|.....||
Mouse   475 -----------------------KTFNQKSELS-------------------------------- 484

  Fly   772 SPFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKISDPNQCVVCDRVLSCK 836
                   .|:      |.|...||                            ::|..|.:..:..
Mouse   485 -------THQ------RLHLGKNS----------------------------HRCSDCGKSFTYA 508

  Fly   837 SALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQ 901
            |.|:||.|.||||:|:|||.||::||....|..|..:||:..|    |:|.:|.|..::...|::
Mouse   509 SQLKMHRRVHTGEKPYKCRDCGKSFTYSFTLNVHRRIHKVEKP----HKCSICGKALASKYQLEE 569

  Fly   902 HIRLHTGEPTDLTPE------------QIQAAEIRDPP------------PSMMPGHFMNPFAAA 942
            |.|:||||...:..|            :.|....||.|            .|.:..|...
Mouse   570 HERIHTGEKPYVCTECGKGFHGRSGFLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQT----- 629

  Fly   943 AFHFGALPGGPGGPPGPNHGAHN-GALGSESSQGDMDDNMDCGE-DYDDDVSSEHLSNSNLEQEG 1005
              |.|..|          :..|. |...|.:||..:...:..|| .|..|..::..|||:..:|.
Mouse   630 --HTGEKP----------YTCHYCGKSFSHTSQLTVHHRIHTGERPYKCDYCAKSFSNSSQLKEH 682

  Fly  1006 DRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRS 1070
            .|..:|:
Mouse   683 LRIHTGE---------------------------------------------------------- 689

  Fly  1071 SSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTV 1135
                           ||.|......:.                     |..:|.|:.|.
Mouse   690 ---------------TPYACSECGKAF---------------------SRRSSLNLHTK------ 712

  Fly  1136 GIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAA 1200
                :..|.:||:..:......|:                 :.|..||   |....|...|.:..
Mouse   713 ----IHTGEKHHICSECGKAFSQK-----------------SVLRTHQ---RIHTGEKPYKCSDC 753

  Fly  1201 AAAAAAAAAAQRQTPPQARD-QRQEGGPGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAM 1264
            ..|.|:..        |.|| ||...|      ..|.|......|.|....|.           .
Mouse   754 GKALASKG--------QLRDHQRIHTG------EKPYMCPECGKGFFGRSSLH-----------R 793

  Fly  1265 NQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTK 1329
            :||..:  ...||            .|..|.|||...|||..|.:.||.|:|:.|..|.:||..|
Mouse   794 HQITHT--KERPF------------VCQKCGKTFIQKSALTSHQQIHTGEKPYVCPECGKGFYNK 844

  Fly  1330 GNLKQHMLTH 1339
            .:|.:|.:||
Mouse   845 SSLPRHQMTH 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	11/30 (37%)
		C2H2 Zn finger	453..473	CDD:275368	10/19 (53%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	826..846	CDD:275368	7/19 (37%)
		zf-H2C2_2	838..863	CDD:290200	15/24 (63%)
		zf-C2H2_2	854..922	CDD:289522	24/79 (30%)
		C2H2 Zn finger	854..874	CDD:275368	8/19 (42%)
		C2H2 Zn finger	886..906	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1291..1311	CDD:275368	9/19 (47%)
		zf-H2C2_2	1303..1328	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1319..1339	CDD:275368	7/19 (37%)
Zfp658	NP_001008549.1	KRAB	23..80	CDD:214630	16/62 (26%)
		C2H2 Zn finger	275..295	CDD:275368	3/21 (14%)
		COG5048	300..684	CDD:227381	120/614 (20%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	10/19 (53%)
		C2H2 Zn finger	358..378	CDD:275368	8/19 (42%)
		C2H2 Zn finger	386..406	CDD:275368	5/44 (11%)
		C2H2 Zn finger	414..434	CDD:275368	3/22 (14%)
		C2H2 Zn finger	442..462	CDD:275368	3/35 (9%)
		C2H2 Zn finger	470..490	CDD:275368	7/111 (6%)
		COG5048	493..887	CDD:227381	118/574 (21%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	2/19 (11%)
		C2H2 Zn finger	610..630	CDD:275368	2/26 (8%)
		C2H2 Zn finger	638..658	CDD:275368	5/19 (26%)
		C2H2 Zn finger	666..686	CDD:275368	6/19 (32%)
		C2H2 Zn finger	694..714	CDD:275368	4/50 (8%)
		C2H2 Zn finger	722..742	CDD:275368	5/39 (13%)
		C2H2 Zn finger	750..770	CDD:275368	7/27 (26%)
		C2H2 Zn finger	778..798	CDD:275368	5/30 (17%)
		C2H2 Zn finger	806..826	CDD:275368	9/19 (47%)
		C2H2 Zn finger	834..854	CDD:275368	7/19 (37%)
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000