DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sem-4

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_491997.1	Gene:	sem-4 / 172435	WormBaseID:	WBGene00004773	Length:	744	Species:	Caenorhabditis elegans

Alignment Length:	952	Identity:	204/952 - (21%)
Similarity:	288/952 - (30%)	Gaps:	486/952 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 CGKVFGSDSALQIHI-RSHTGERP-FKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEH 518
            |.:.|.|.:||..|: .:|..|:. |.|:||.:.|:...:::.|   ..||
Worm   106 CSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFSNGQDIREH---KCQK-------------- 153

  Fly   519 MDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASF----PPAFPGLQNLYRPPMEILKSLGAAAP 579
                            :..:.|.:.|| .:.|:|.    .|..|.||      ..|.:|:|.:
Worm   154 ----------------TLASRSTSVPP-STIPSSVCFLSTPTTPCLQ------FSINESIGTS-- 193

  Fly   580 HQYFPQELPTDLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEER 644
                                              :.|||.|:|                   :..
Worm   194 ----------------------------------EIREEDEEE-------------------DMD 205

  Fly   645 VEEQEQVKQE--DHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSH 707
            ||:.|.|..:  .|.::       .|:.:|......:| .:||.
Worm   206 VEDGEHVANQLFGHLLQ-------KSDDKSKMASLFNH-AFPPF--------------------- 241

  Fly   708 LDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARS 772
                                                         |..|.:|||      .:.|.
Worm   242 ---------------------------------------------AAFPNMPPP------FLMRQ 255

  Fly   773 PFFNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKI--SDPNQCVVCDRVLSC 835
            | |:|.....||   ..|.||:.||..:|:|.:.|..|::.|:.:|.:  :|||||::|.|||||
Worm   256 P-FDPRADVFAA---GRHDNDDDWEALMEISTSDEAEKIRALVGDKAVPTTDPNQCILCRRVLSC 316

  Fly   836 KSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHK------------------------- 875
            |||||||||||||||||||:||.|||||||||||||.||:
Worm   317 KSALQMHYRTHTGERPFKCKICQRAFTTKGNLKTHMGVHRSKHSFRGLPISLPPQLAAMHQHQHQ 381

  Fly   876 IRPPMR-NFH--------------------QCPVCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQ 919
            |.||.| :.|                    |||:|.:::.||..|..||..|....|.
Worm   382 IAPPQRIHIHNPPTSAASAAAAVAQIQASQQCPICQQRFLNAGELAVHITEHRNSLTQ------- 439

  Fly   920 AAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCG 984
                   ||.:||
Worm   440 -------PPRVMP---------------------------------------------------- 445

  Fly   985 EDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSV 1049
                                                    ...|..|.|.|..|..:
Worm   446 ----------------------------------------TPTTTRVQTFPFVPFFT-------- 462

  Fly  1050 GSTSAPTSPSVHAS------------SQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLP 1102
                  |.||::|:            |..:|..|||                 .|.:||....:.
Worm   463 ------TPPSLNATDMSTQFNLANILSAQLKNDSSP-----------------NTDTSSVEEKIT 504

  Fly  1103 KEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAA 1167
            ::.|....||  |||.||.:|:::
Worm   505 RDDPPKMASL--SPSNSSDSSSSV----------------------------------------- 526

  Fly  1168 AQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPP 1232
                 .|.:....:.:|:|::                       .:.||....|       ....
Worm   527 -----RQDILESSEFEEKLKK-----------------------LEEPPILEQQ-------VSTT 556

  Fly  1233 PNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKT 1297
            |||                    ..:|...||.::.....|..|.....||    ...||:|:|.
Worm   557 PNP--------------------KNENPLLAMQKMWAETEPPPPRQMPVLS----KHQCGVCFKH 597

  Fly  1298 FPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            |...|||:||.|:||.::||||.:|.|.|||:||||.||.||
Worm   598 FSSSSALQIHMRTHTGDKPFKCDMCGRAFTTRGNLKVHMGTH 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	6/17 (35%)
		C2H2 Zn finger	453..473	CDD:275368	6/17 (35%)
		zf-H2C2_2	465..490	CDD:290200	10/26 (38%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		C2H2 Zn finger	826..846	CDD:275368	16/19 (84%)
		zf-H2C2_2	838..863	CDD:290200	22/24 (92%)
		zf-C2H2_2	854..922	CDD:289522	34/113 (30%)
		C2H2 Zn finger	854..874	CDD:275368	16/19 (84%)
		C2H2 Zn finger	886..906	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1291..1311	CDD:275368	11/19 (58%)
		zf-H2C2_2	1303..1328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1319..1339	CDD:275368	12/19 (63%)
sem-4	NP_491997.1	C2H2 Zn finger	307..327	CDD:275368	16/19 (84%)
		zf-H2C2_2	319..344	CDD:290200	22/24 (92%)
		C2H2 Zn finger	335..355	CDD:275368	16/19 (84%)
		lambda-1	553..>610	CDD:212564	20/80 (25%)
		zf-C2H2	589..611	CDD:278523	11/21 (52%)
		C2H2 Zn finger	591..611	CDD:275368	11/19 (58%)
		zf-H2C2_2	603..628	CDD:290200	14/24 (58%)
		C2H2 Zn finger	619..639	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166290
Domainoid	1	1.000	49	1.000	Domainoid score	I7969
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm14690
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.960