DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and ZNF721

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_597731.2	Gene:	ZNF721 / 170960	HGNCID:	29425	Length:	923	Species:	Homo sapiens

Alignment Length:	1198	Identity:	209/1198 - (17%)
Similarity:	331/1198 - (27%)	Gaps:	467/1198 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 QQQLFQIQLIQQLQSQLALNQAKQEEDTEE----------------DADQEQDQEQETDTYEEEE 298
            |.::||.....::.|:.|.:...:...|.|                |..|.:........|..||
Human    77 QSKIFQCNARVKVFSKFANSNKDKTRHTGEKHFKCNECGKSFQKFSDLTQHKGIHAGEKPYTCEE 141

  Fly   299 RIADM----ELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDHESQPNRRPSLD 359
            |..|.    :|.|..:....|...:..  ..|.....|:...|    .:|.|:.|
Human   142 RGKDFGWYTDLNQHKKIHTGEKPYKCE--ECGKAFNRSTNLTA----HKRIHNRE---------- 190

  Fly   360 NTHKADTAQDA---------LAKLKEMENTPLPF------GSDLASSIITNHDDL---PEPNSLD 406
               ||.|.:|.         |.:.|::.....|:      .:.:.||.:..|:.:   .:|...
Human   191 ---KAYTGEDRDRAFGWSTNLNEYKKIHTGDKPYKCKECGKAFMHSSHLNKHEKIHTGEKPYKC- 251

  Fly   407 LLQKRAQEVLDSASQGILANSMADDFAFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIR 471
               |...:|:.|:|          .||..::...|:   :||   :|..|||.|...:.|..|.|
Human   252 ---KECGKVISSSS----------SFAKHKRIHTGE---KPF---KCLECGKAFNISTTLTKHRR 297

  Fly   472 SHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSS 536
            .||||:|:.|.|||..|....||.||.:.|..:.|:.
Human   298 IHTGEKPYTCEVCGKAFRQSANLYVHRRIHTGEKPYT---------------------------- 334

  Fly   537 PNHSPAPPPLGSAPASFPPAFPGLQNLY---------RPPM--EILKSLGA-AAPHQYFPQELPT 589
                     .|....:|..:    .|||         :|..  :..|:.|. .|.:|:  :::.|
Human   335 ---------CGECGKTFRQS----ANLYVHRRIHTGEKPYKCEDCGKAFGRYTALNQH--KKIHT 384

  Fly   590 DLRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQE 654
            .   ..|...|:..:..|........:..|.:|.....|.......|...:.|
Human   385 G---EKPYKCEECGKAFNSSTNLTAHKRIHTREKPYTCEDRGRAFGLSTNLNE------------ 434

  Fly   655 DHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLDHLPTPGQLPP 719
                                 ::..|.|..|........|.:|       ..||:
Human   435 ---------------------YKKIHTGDKPYKCKECGKAFIH-------SLHLN---------- 461

  Fly   720 REDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPF---------- 774
                                                       .|...|..:.|:
Human   462 -------------------------------------------KHEKIHTGKKPYKCKQCGKVIT 483

  Fly   775 --FNPIKHEMAALLPRPHSNDNSWENFIEVSN--TCETMKLKELMKNKKI---SDPNQCVVCDRV 832
              .:..||:      |.|:.:..:| .:|...  |..|    .|.|:::|   ..|..|.||.:.
Human   484 SSSSFAKHK------RIHTGEKPFE-CLECGKAFTSST----TLTKHRRIHTGEKPYTCEVCGKA 537

  Fly   833 LSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNAL 897
            ....:.|.:|.|.||||:|:.|..||:.|....||..|..:|....|    ::|..|.|.:....
Human   538 FRQSAILYVHRRIHTGEKPYTCEECGKTFRQSANLYVHRRIHTGEKP----YKCEECGKAFGRYT 598

  Fly   898 VLQQHIRLHTGEP--------------TDLTPE-QIQAAEIRDPPPSMMPGHFMNPFAAAAFHFG 947
            .|.||.::||||.              |||..: :|...|              .|:.....
Human   599 DLNQHKKIHTGEKLYKCEECGKDFVWYTDLNQQKKIYTGE--------------KPYKCEEC--- 646

  Fly   948 ALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDVS-SEHLSNSNLEQEGDRSRSG 1011
                |....|..:...|...|..|.|.    ...:||:.:...:: ::|......|:.......|
Human   647 ----GKAFAPSTDLNQHTKILTGEQSY----KCEECGKAFGWSIALNQHKKIHTGEKPYKCEECG 703

  Fly  1012 DDF---KSLLFEQKLRIDATGVVNTNPVRPRSSASSHGHSVG-STSAPTSPSVHAS--------- 1063
            ..|   ::|...:::.      ....|.:    ....|.|.| ||:......:|..
Human   704 KAFSRSRNLTTHRRVH------TREKPYK----CEDRGRSFGWSTNLNEYKKIHTGDKLYKCKEC 758

  Fly  1064 SQVIKRSSSPARSEASQGALDLTPRAAP----------TSSSSSRSPLPKEKPVSPPSLPRS--P 1116
            .:|.|:||...|.|      .:.....|          |||||    ..|.|.:.....|..  .
Human   759 GKVFKQSSHLNRHE------KIHTGKKPYKCKECGKVITSSSS----FAKHKRIHTGEKPFKCLE 813

  Fly  1117 SGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQ 1181
            .|.:..|:..||                      :|:.:...:.........:  ..:|.|.|:.
Human   814 CGKAFTSSTTLT----------------------KHRRIHTGEKPYTCEECGK--AFRQSAILYV 854

  Fly  1182 HQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMF 1246
            |:.                                                   :.....|:
Human   855 HRR---------------------------------------------------IHTGEKPY--- 865

  Fly  1247 PNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSH 1311
                                                       |||.|.|||...:.|..|.:.|
Human   866 -------------------------------------------TCGECGKTFRQSANLYAHKKIH 887

  Fly  1312 TKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            |.|:|:.|..|.:.|....||..|...|
Human   888 TGEKPYTCGDCGKTFRQSANLYAHKKIH 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	8/21 (38%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	13/24 (54%)
		C2H2 Zn finger	481..501	CDD:275368	9/19 (47%)
		C2H2 Zn finger	826..846	CDD:275368	6/19 (32%)
		zf-H2C2_2	838..863	CDD:290200	12/24 (50%)
		zf-C2H2_2	854..922	CDD:289522	23/82 (28%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1319..1339	CDD:275368	6/19 (32%)
ZNF721	NP_597731.2	C2H2 Zn finger	83..103	CDD:275368	2/19 (11%)
		COG5048	93..492	CDD:227381	93/576 (16%)
		C2H2 Zn finger	111..131	CDD:275368	2/19 (11%)
		C2H2 Zn finger	139..159	CDD:275368	6/19 (32%)
		zf-H2C2_2	151..176	CDD:290200	4/26 (15%)
		C2H2 Zn finger	167..187	CDD:275368	4/25 (16%)
		C2H2 Zn finger	223..243	CDD:275368	3/19 (16%)
		zf-H2C2_2	235..257	CDD:290200	3/25 (12%)
		C2H2 Zn finger	251..271	CDD:275368	6/33 (18%)
		C2H2 Zn finger	279..299	CDD:275368	8/19 (42%)
		zf-H2C2_2	292..316	CDD:290200	13/23 (57%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		zf-H2C2_2	319..344	CDD:290200	8/61 (13%)
		C2H2 Zn finger	335..355	CDD:275368	5/23 (22%)
		zf-H2C2_2	347..372	CDD:290200	5/24 (21%)
		C2H2 Zn finger	363..383	CDD:275368	4/21 (19%)
		zf-H2C2_2	375..400	CDD:290200	5/29 (17%)
		C2H2 Zn finger	391..411	CDD:275368	2/19 (11%)
		COG5048	442..885	CDD:227381	110/683 (16%)
		C2H2 Zn finger	447..467	CDD:275368	5/79 (6%)
		C2H2 Zn finger	475..495	CDD:275368	3/25 (12%)
		zf-H2C2_2	487..512	CDD:290200	6/31 (19%)
		C2H2 Zn finger	503..523	CDD:275368	5/23 (22%)
		zf-H2C2_2	516..540	CDD:290200	7/23 (30%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..568	CDD:290200	12/23 (52%)
		C2H2 Zn finger	559..579	CDD:275368	7/19 (37%)
		zf-H2C2_2	571..596	CDD:290200	8/28 (29%)
		C2H2 Zn finger	587..607	CDD:275368	6/19 (32%)
		C2H2 Zn finger	615..634	CDD:275368	3/18 (17%)
		C2H2 Zn finger	643..663	CDD:275368	3/26 (12%)
		C2H2 Zn finger	671..691	CDD:275368	3/19 (16%)
		zf-H2C2_2	683..708	CDD:290200	4/24 (17%)
		C2H2 Zn finger	699..719	CDD:275368	3/19 (16%)
		C2H2 Zn finger	755..775	CDD:275368	6/25 (24%)
		zf-H2C2_2	767..789	CDD:290200	3/27 (11%)
		C2H2 Zn finger	783..803	CDD:275368	7/23 (30%)
		zf-H2C2_2	795..820	CDD:290200	5/28 (18%)
		C2H2 Zn finger	811..831	CDD:275368	5/41 (12%)
		zf-H2C2_2	824..848	CDD:290200	3/47 (6%)
		C2H2 Zn finger	839..859	CDD:275368	4/72 (6%)
		zf-H2C2_2	852..876	CDD:290200	10/120 (8%)
		C2H2 Zn finger	867..887	CDD:275368	8/19 (42%)
		C2H2 Zn finger	895..915	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000