DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and ZNF765-ZNF761

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001337425.1	Gene:	ZNF765-ZNF761 / 110116772	-ID:	-	Length:	746	Species:	Homo sapiens

Alignment Length:	1153	Identity:	210/1153 - (18%)
Similarity:	321/1153 - (27%)	Gaps:	513/1153 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 DTEEDADQEQ----DQEQET---DTYEEEER-IADMELRQKAEAR--MAEAKARQHLINAG-VPL 329
            |...:..||:    |..|.|   |...|..| :..:::..|...:  ::.|:..:.:.:|| :.:
Human    12 DVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCTMKEFLSTAQGNREVFHAGTLQI 76

  Fly   330 RES--SGSPAESLKRRREHDHES--QPNRRPSLDNTHKADTAQDALAKLKEM------------E 378
            .||  :|........:..||:|.  |.:.|    |.|:|     .:.|:|::            .
Human    77 HESHHNGDFCYQDVDKDIHDYEFQWQEDER----NGHEA-----PMTKIKKLTGITERYDQSHAR 132

  Fly   379 NTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEV--------LDSASQGI-------LANSM 428
            |.|:.  ..|.||.   |..|||.:.....:|...:|        |.|.:|.|       ::|:.
Human   133 NKPIK--DQLGSSF---HSHLPEMHIFQTEEKIDNQVVKSVHDASLVSTAQRISCRPKTHISNNH 192

  Fly   429 ADDF------------AFGEKSGE----GKGRNEPFF-----------KHRCRYCGKVFGSDSAL 466
            .::|            ...|||.:    ||..|....           |::|..|||:|.....|
Human   193 GNNFWNSSLLTQKQEVHMREKSFQCNESGKAFNYSSLLRKHQIIHLADKYKCDVCGKLFNQKRNL 257

  Fly   467 QIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDK-FHPPLLDQM 530
            ..|.|.||||.|:|||.||..|:...:|..|.:.|..:.|:.       .|..|| ||
Human   258 ACHRRCHTGENPYKCNECGKTFSQTSSLTCHRRLHTGEKPYK-------CEECDKAFH------- 308

  Fly   531 SPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLGAAAPHQYFPQELPTDLRKPS 595
                                      |..:...:|    |:.:
Human   309 --------------------------FKSILERHR----IIHT---------------------- 321

  Fly   596 PQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQEDHRIEP 660
                |::|...|                 ||.                :...|:.:....||:..
Human   322 ----EEKPYKCN-----------------ECG----------------KTFRQKSILTRHHRLHT 349

  Fly   661 RRTPSPSSE------HRS--PHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQ-SHLDHLPTPGQ 716
            ...|...:|      |:|  ..||| .|.|..|           :..:..|.. ||...|....:
Human   350 GEKPYKCNECGKTFSHKSSLTCHHR-LHTGEKP-----------YKCNECGKTFSHKSSLTCHRR 402

  Fly   717 LPPREDFF-------AERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPF 774
            |...|..:       |..|..||...:.:..|.::...:..|... ........|...|....|:
Human   403 LHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECGKTF-SRTSSLTCHRRRHTGEQPY 466

  Fly   775 FNPIKHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKNKKI---SDPNQCVVCDRVLSCK 836
                |.|......|..||                     |.::::|   ..|.:|..|.:..|.|
Human   467 ----KCEECDKAFRFKSN---------------------LERHRRIHTGEKPYKCNECGKTFSRK 506

  Fly   837 SALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQ 901
            |.|..|:|.||||:.:||..||:.|:.|.:|..|..:|....|    ::|..|.|.::..|.|::
Human   507 SYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKP----YKCKECGKTFNQQLTLKR 567

  Fly   902 HIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNG 966
            |.|||:||                           ||:..
Human   568 HRRLHSGE---------------------------NPYKC------------------------- 580

  Fly   967 ALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDATGVV 1031
                              ||.|...|.:    ||||                ..||:..:
Human   581 ------------------EDSDKAYSFK----SNLE----------------IHQKIHTE----- 602

  Fly  1032 NTNPVRPRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSS 1096
             .||.:    .:..|.:...||:.|      ..:.:.....|.:.|....|.     ...::...
Human   603 -ENPYK----CNECGKTFSRTSSLT------CHRRLHTGEKPYKCEECDKAF-----RVKSNLEG 651

  Fly  1097 SRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPPTVGIDCLPPGLQHHLQQQHQHLMQQQAA 1161
            .|.....|||.......::.|..|:               ..|
Human   652 HRRIHTGEKPYKCNECGKTFSRKSY---------------FIC---------------------- 679

  Fly  1162 VAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQARDQRQEGG 1226
                      ||:    ||
Human   680 ----------HHR----LH---------------------------------------------- 684

  Fly  1227 PGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTC 1291
                      .|.:|                                               ..|
Human   685 ----------TGEKP-----------------------------------------------YKC 692

  Fly  1292 GICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTH 1339
            ..|.|.|...|:|..|:|.||.|:|:||:.|.:.|:.|.||..|...|
Human   693 NECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFSQKSNLTCHRRLH 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	8/21 (38%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	14/24 (58%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	826..846	CDD:275368	8/19 (42%)
		zf-H2C2_2	838..863	CDD:290200	12/24 (50%)
		zf-C2H2_2	854..922	CDD:289522	20/67 (30%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1319..1339	CDD:275368	7/19 (37%)
ZNF765-ZNF761	NP_001337425.1	KRAB	7..48	CDD:307490	9/35 (26%)
		C2H2 Zn finger	217..237	CDD:275368	3/19 (16%)
		COG5048	242..617	CDD:227381	120/619 (19%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	8/56 (14%)
		C2H2 Zn finger	328..348	CDD:275368	6/52 (12%)
		C2H2 Zn finger	356..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	384..404	CDD:275368	4/19 (21%)
		C2H2 Zn finger	412..432	CDD:275368	4/19 (21%)
		C2H2 Zn finger	440..460	CDD:275368	2/20 (10%)
		C2H2 Zn finger	468..488	CDD:275368	5/40 (13%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	552..572	CDD:275368	7/19 (37%)
		C2H2 Zn finger	580..600	CDD:275368	10/82 (12%)
		C2H2 Zn finger	608..628	CDD:275368	4/25 (16%)
		C2H2 Zn finger	636..656	CDD:275368	3/24 (13%)
		SFP1	<651..737	CDD:227516	32/239 (13%)
		C2H2 Zn finger	664..684	CDD:275368	5/70 (7%)
		C2H2 Zn finger	692..712	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000