DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and bcl11bb

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_002667906.3	Gene:	bcl11bb / 100330974	ZFINID:	ZDB-GENE-110201-2	Length:	794	Species:	Danio rerio

Alignment Length:	877	Identity:	179/877 - (20%)
Similarity:	281/877 - (32%)	Gaps:	303/877 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 EHEQEM-----------AEC---SEPEPEPL---------PLEVRIKEERVEEQEQVKQEDHRIE 659
            ||::.:           ::|   ..|.|.||         |:||.|:....||:|:      |:.
Zfish    71 EHKRRLCPGPSSCFDKPSDCGGSGSPSPRPLRPDVCRRSGPVEVGIQVSPREEEEK------RLT 129

  Fly   660 PRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPA--ALMHPQSSPGSQSHLDHLPTPGQLPPR-- 720
            |.|...|..|.........|........||...|  .|.|.|::.|.:.:||..||...|.||
Zfish   130 PARGICPKQEGVPTGKDEPSSYICTTCKQPFTSAWFLLQHAQNTHGIRIYLDTHPTSCSLTPRMA 194

  Fly   721 --EDFFAERFPLN------------FTTAKMLSPEHHSPVRSPAGG-------ALPPGVPPPPHH 764
              ....|:..|.:            |...:|.:|    .:|.|..|       :.||.|.|||..
Zfish   195 LPPPLGADALPRSPLASFLGDGSNPFQLLRMGAP----LLREPPHGYIETRLPSTPPFVSPPPPR 255

  Fly   765 HPHHMARSPFFNPIKHEMAALLPRPHSNDNSWENFIEVS-------NTCETMKLKELMKNKKISD 822
            ||  :.|   ..|  .||..|...|    :::|..:.::       :...:.:|:||..|.....
Zfish   256 HP--LER---LGP--EEMGLLSQHP----SAFERVMRMTPMGIHEPSMGFSQRLRELAGNNNNGG 309

  Fly   823 P--------------------------------------------------NQ------CVVCDR 831
            |                                                  ||      |..|.:
Zfish   310 PTPPLSPNRVPPMHRLLSPTLFQHGSKALPFLPTPSQPPSIPSRGNSSSPLNQVGKAKSCEFCGK 374

  Fly   832 VLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNA 896
            ....:|.|.:|.|:||||||:||.:|..|.:....||.||..|
Zfish   375 TFKFQSNLIVHRRSHTGERPYKCHLCDHACSQASKLKRHMKTH---------------------- 417

  Fly   897 LVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNH 961
                    :|.......:|||                            .|....|.|.....::
Zfish   418 --------MHKSGSMGSSPEQ----------------------------GGQDSAGEGLKSCEDN 446

  Fly   962 GAHNGALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKL--- 1023
            |...| :.:|..:.|.::..:  |:.:::..:....:|||..:.:.||:.::......|.|.
Zfish   447 GTREG-IDNEEEEDDEEEEEE--EEEEEEQQNGSRPDSNLSMDSELSRNRENGPRTTPEDKPLAT 508

  Fly  1024 -RIDATGVVN-TNPVR-PRSSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDL 1085
             |:..:...| .|.:| |..|....|....|           .::.|.|...|..:....|..|
Zfish   509 DRVTESQYNNLDNHLRLPPGSRPCEGMDRDS-----------QAREIDRDRQPMVNGRGCGPED- 561

  Fly  1086 TPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANI---LTSPLPPTVGIDCLPPGLQHH 1147
                 ..|:...|.|:    |:|..||    ||||.....:   :..|..|.:.    |..:...
Zfish   562 -----SISAMFHRKPM----PISSSSL----SGSSAKRIKVEKDVELPQVPVIS----PENVYSQ 609

  Fly  1148 LQQQHQHLMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQR 1212
            |             :|..||::|...:.....:..::......:|         .:::...:.:.
Zfish   610 L-------------LAGYAASRHFIREPFLGFNDSRQSPFGTPSE---------HSSSETGSLRF 652

  Fly  1213 QTPPQARDQRQEGG--PGAGPPPNPLMGARPPFGMFPNLPLFPPATTQNMCNAMNQIAQSVMPAA 1275
            .|||   .:..|||  .|......|.:..|.|.      |..||::.::
Zfish   653 STPP---GEILEGGGMSGRSDSSTPHLHLRGPG------PGRPPSSKES---------------- 692

  Fly  1276 PFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHK 1340
                      |.|.||..|.|.|...|.|.:|.||||.|||:||.:|.........|.:||.||
Zfish   693 ----------RRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCDLCSYACAQSSKLTRHMKTH- 746

  Fly  1341 IRDMEQETFR-----------NRAVKYMSEWN 1361
             ....:|.:|           :...|::.:|:
Zfish   747 -GQFGKEVYRCDICHMPFSVYSTLEKHVKKWH 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523
		C2H2 Zn finger	453..473	CDD:275368
		zf-H2C2_2	465..490	CDD:290200
		C2H2 Zn finger	481..501	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368	6/19 (32%)
		zf-H2C2_2	838..863	CDD:290200	13/24 (54%)
		zf-C2H2_2	854..922	CDD:289522	12/67 (18%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1291..1311	CDD:275368	8/19 (42%)
		zf-H2C2_2	1303..1328	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1319..1339	CDD:275368	5/19 (26%)
bcl11bb	XP_002667906.3	zf-C2H2	368..389	CDD:278523	6/20 (30%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	381..406	CDD:290200	13/24 (54%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		zf-C2H2	697..718	CDD:278523	9/20 (45%)
		C2H2 Zn finger	698..718	CDD:275368	8/19 (42%)
		zf-H2C2_2	710..735	CDD:290200	12/24 (50%)
		C2H2 Zn finger	726..746	CDD:275368	5/19 (26%)
		C2H2 Zn finger	756..774	CDD:275368	1/17 (6%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930