DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sall2

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	XP_004910803.1	Gene:	sall2 / 100038135	XenbaseID:	XB-GENE-494377	Length:	1114	Species:	Xenopus tropicalis

Alignment Length:	1388	Identity:	328/1388 - (23%)
Similarity:	492/1388 - (35%)	Gaps:	481/1388 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KQLKDRARSADKDIGSDQEENGGCSPLTTATTTASPSRSPEPEEEQPEEQSTSEQSIPEQSTPDH 103
            ||.|.:...:|.| .|...|||     .||.......|....:.::|.:.:..:    |..|.|
Frog     5 KQRKPQQLISDCD-NSTSSENG-----DTAGEEVQVCRKCCAQFDEPSDFARHK----EYCTLD- 58

  Fly   104 QLENDIKSEAKSEIEPVEDNNNRVAMTKPSSEEREPNASG--SMPSSPVAEASAEEAATERTPEK 166
                       |::..:.||..     :|...::...:.|  |.||||....:     ..:|...
Frog    59 -----------SQVVVIVDNQE-----EPLKNQQTIISEGVNSTPSSPDCRRT-----VHKTLVT 102

  Fly   167 EKEKDVE---VDVEKPDEAPSSAVPSTEVTLPGGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNG 228
            |.::|..   :...:.|....:...|....:|.|:   :.::.:...:..:|....:|::.|...
Frog   103 EHDRDPSTGIIGATRQDLGKKAVGLSQGFLIPNGS---LIMDGLSGPKFGLAPMNQETLSGGQAA 164

  Fly   229 ADNEAAMKQLAFLQQTLFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDT 293
                ||...:..:.:.|..|||:|:.|:|:.:|:..|:.:
Frog   165 ----AAPINIPMILEELRVLQQRQIHQMQITEQICQQVLM------------------------- 200

  Fly   294 YEEEERIADMELRQKAEARMAEAKARQHLINAGVPLRESSGSPAESLKRRREHDHESQPNRRPSL 358
                                        |.:..:|....:.||||.          :..|:.||.
Frog   201 ----------------------------LGSLTMPSLIQNTSPAEG----------TIGNKSPSA 227

  Fly   359 DN----THKADTAQ----DALAK--LKEMENTPLPFGSDLASSIITNHDD-----LPE------- 401
            .|    :|.|::|:    |..:|  |..:.|   |.|..|::..|.|..|     .||
Frog   228 FNPPKQSHLAESAKTFCGDDASKQALLHLYN---PMGQSLSTRTIANGKDKLLGGFPEKPSPGQN 289

  Fly   402 -----------------PNSLDLLQK---RAQEVLDSASQGILANSMADDFAFGEKSGE-GKGRN 445
                             |.||..||.   ....||::|..  |......|...||...| ..||
Frog   290 SLPTSPQNQLLSPHAIFPPSLPTLQTGLFLGARVLETAPS--LLKQKNSDSLRGESQQERASGR- 351

  Fly   446 EPFFKHRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPM 510
                 |:||:|.||||||||||||:||||||||:|||:||:||||:|||||||.||.:|:||:.|
Frog   352 -----HKCRFCAKVFGSDSALQIHLRSHTGERPYKCNICGNRFTTRGNLKVHFHRHREKYPHIQM 411

  Fly   511 NATPIPEHMDKFHPPLLDQMSPTDSSPNHSPAPPPLGSAPASFPPAFPGLQNLYRPPMEILKSLG 575
            |..|:|||:|                                                .:|.|.|
Frog   412 NPHPVPEHLD------------------------------------------------YVLTSTG 428

  Fly   576 AAAPHQYFPQELPTDLRKPSPQLDED----EPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPL 636
                       ||..:..|..:.||:    :|.|  .||...|       .::..|....:.||
Frog   429 -----------LPYGMSVPPEKADEETVDKKPLV--SPVLATD-------SLSLFSTSSIQGLP- 472

  Fly   637 EVRIKEERVEEQEQVKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSS 701
                   .:.....:|..|                          |.|         ||..|..|
Frog   473 -------SLNRMVLMKTGD--------------------------GVP---------ALKGPSGS 495

  Fly   702 PGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHP 766
            |  ::.:|....||:                              ||..||.   ||       .
Frog   496 P--KTKIDENTPPGE------------------------------RSDNGGT---GV-------G 518

  Fly   767 HHMARSPFFNPI-------KHEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMK--NKKISD 822
            ..:..|.....:       .|..:..||.|::        :|.....||.||::|::  :|:.:.
Frog   519 SRVQLSKLVTSLPSWALLASHFKSGALPFPYT--------VEPLGYSETSKLQQLVEKIDKQATV 575

  Fly   823 PNQCVVCDRVLSCKSALQMHYRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCP 887
            |||||:|.|||||..||::||..|.|||||||::|||||:||||||.|...||.....:..:.||
Frog   576 PNQCVICLRVLSCPRALRLHYNQHGGERPFKCKVCGRAFSTKGNLKAHFVGHKTSLSSKPQNSCP 640

  Fly   888 VCHKKYSNALVLQQHIRLHTGEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGG 952
            :|.||::||:.||||||:|.|                                      |.:|.|
Frog   641 ICQKKFTNAVTLQQHIRMHLG--------------------------------------GQIPNG 667

  Fly   953 P-----GGPPGPNHGAHNGALGSESSQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGD 1012
            .     .|........||.                   |:.|:||::..|....|.|.:::...|
Frog   668 ELTEVGEGKTEVQPAKHNA-------------------DFSDEVSTDVDSLEGTESESEKTALVD 713

  Fly  1013 -DFKSLLFEQKLRIDATGVVNTNPVRPRSSASSHG--HSVGS----TSA--PTSPSVHASSQVIK 1068
             :..||       .|.....:|:.....::.||..  |.:.|    ||:  |.||:.....|...
Frog   714 TEISSL-------DDDAAAGSTDKKNDENNISSFASIHPIPSIAKDTSSPEPISPTETVPLQTTN 771

  Fly  1069 RSSSPARSEASQGALDLTPRAAPTSSSSSRSPLPKEKPVSPPSLPRSPSGSSHASANILTSPLPP 1133
            :..:..:.:..:....:..:...|..|...:...|::.:.......|........|:|.......
Frog   772 QQMNNEKEDKMETESSMYEQNINTKDSVDENKTGKKEDLEAKVTNISEESPQEMEAHICNLCSDK 836

  Fly  1134 TVGIDCLPPGLQHHLQQQHQH-LMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKA 1197
            ....:.|....:.|.:....| |:.||:.:..:...:|       .||.||
Frog   837 FSTYESLEDHAKSHTKDGLFHCLICQQSFLEVSILKKH-------VLHVHQ-------------- 880

  Fly  1198 AAAAAAAAAAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPNL-----------PL 1251
                        ..:..|.|                 |:...:.|.|..|.|           .:
Frog   881 ------------VSQNFPSQ-----------------PVSSPKCPAGDLPTLTQTFLLSSVKSEV 916

  Fly  1252 FPPATTQNMCNAMNQIAQSVMPAAPFNPLALSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERP 1316
            ..|  :||:  |:.|..:..:|:....||..|..:  ..|.:|.|||...|||:||.|.||.|:|
Frog   917 VSP--SQNL--ALVQFPRLQVPSHVSPPLRRSPKQ--HLCMVCKKTFSSASALQIHERIHTGEKP 975

  Fly  1317 FKCSICDRGFTTKGNLKQHMLTH 1339
            |.|::|.|.|||:||||.||.||
Frog   976 FICNMCGRAFTTRGNLKVHMSTH 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	20/24 (83%)
		C2H2 Zn finger	481..501	CDD:275368	15/19 (79%)
		C2H2 Zn finger	826..846	CDD:275368	12/19 (63%)
		zf-H2C2_2	838..863	CDD:290200	17/24 (71%)
		zf-C2H2_2	854..922	CDD:289522	30/67 (45%)
		C2H2 Zn finger	854..874	CDD:275368	13/19 (68%)
		C2H2 Zn finger	886..906	CDD:275368	13/19 (68%)
		C2H2 Zn finger	1291..1311	CDD:275368	11/19 (58%)
		zf-H2C2_2	1303..1328	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1319..1339	CDD:275368	12/19 (63%)
sall2	XP_004910803.1	C2H2 Zn finger	354..374	CDD:275368	16/19 (84%)
		zf-H2C2_2	366..391	CDD:372612	20/24 (83%)
		C2H2 Zn finger	382..402	CDD:275368	15/19 (79%)
		C2H2 Zn finger	579..599	CDD:275368	12/19 (63%)
		zf-H2C2_2	591..616	CDD:372612	17/24 (71%)
		C2H2 Zn finger	607..630	CDD:275368	15/22 (68%)
		zf-C2H2	638..659	CDD:333835	13/20 (65%)
		C2H2 Zn finger	639..659	CDD:275368	13/19 (68%)
		C2H2 Zn finger	830..850	CDD:275370	1/19 (5%)
		C2H2 Zn finger	858..879	CDD:275370	6/27 (22%)
		C2H2 Zn finger	950..970	CDD:275368	11/19 (58%)
		zf-H2C2_2	962..987	CDD:372612	14/24 (58%)
		zf-C2H2	976..998	CDD:333835	13/21 (62%)
		C2H2 Zn finger	978..998	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm48607
Panther	1	1.100	-	-	O	PTHR23233
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020