DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and sall1

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001090646.1	Gene:	sall1 / 100036618	XenbaseID:	XB-GENE-491393	Length:	1330	Species:	Xenopus tropicalis

Alignment Length:	1433	Identity:	384/1433 - (26%)
Similarity:	553/1433 - (38%)	Gaps:	492/1433 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KQLKDRARSADKDI---GSDQEENGGCSPLTTATTTASPSRSPEPEE---EQPEEQSTSEQSIPE 97
            ||.|.:...:|..:   ||    :|....|....:..|.....||||   :...|::|....|
Frog     5 KQAKPQHFQSDPGLALPGS----HGTLDLLQLRISRESEEMKSEPEEIKLKFNHERNTERGQI-- 63

  Fly    98 QSTPDHQLENDIKSEAKSEIEPVED-----------------NNN-----RVAMTKPSSEEREPN 140
            ..||.:: |..:.|...:|...:.|                 |.|     ..:...|.|:..:.:
Frog    64 HRTPKNK-EAHVCSRCCAEFFELSDLLQHKKNCTKNQLVLIVNENPPPPAEASSPIPPSDNPDEH 127

  Fly   141 ASGSMPSSPVAEAS-AEEAATERTPEKEKEKDVEVD-----------VEKPDEA---PSSAVPST 190
            .:.::.:|..|:.| ..|......|:||:..:||..           |:..|.:   |:....:.
Frog   128 MNDTVNNSDQADCSDLSEHGEHGKPDKEESMEVEFSETNNSSSGSNKVDNGDSSSNNPTLGTSAI 192

  Fly   191 EVTLP-----------GGAGAPVTLEAIQNMQMAIAQFAAKTIANGSNGADNEAAMKQLAFLQQT 244
            ..:||           ....:.|.:|.:|:.::|:|||:.:....|:  |:|:.|:..   |.:.
Frog   193 TTSLPQVRDLTALGNFSMINSNVIIENLQSTRVAVAQFSQEAKTKGA--ANNKLAVPA---LMEQ 252

  Fly   245 LFNLQQQQLFQIQLIQQLQSQLALNQAKQEEDTEEDADQEQDQEQETDTYEEEERIADMELRQK- 308
            |..|||||:.|:.||:|::.|:.| .|.|..|....|...|...:.:.|   ........|.|:
Frog   253 LLALQQQQIHQLHLIEQIRHQILL-LASQSADMPTSASGPQGALRVSAT---PLTTLSSHLSQQL 313

  Fly   309 -AEARMAEAKARQHLINAGV----PLRESSGSPAESLKRRREHDHESQPNRR--------PSLDN 360
             |.|.:|::.|.|....:|:    |::....:|..::    .....|.||..        ||.|.
Frog   314 AAAAGLAQSLASQSASISGMKQLPPIQLPQSNPVNTV----PSISSSSPNMNALASTVTSPSSDK 374

  Fly   361 THKADTAQDALAKLKEMENTPLPFGSDLASSIITNHDDLPEPNSLDLLQKRAQEVLDSASQGILA 425
            ...:...       .::.|.|.|..|..|.:|    ..|..|.|..||.:.|...  :...|.|.
Frog   375 VPSSTGG-------SQVSNPPAPVTSSPAFAI----SSLLSPASNPLLPQPAPNT--TPFPGTLP 426

  Fly   426 N--SMADDF------------AFGEKSGEGKGRNEPFFKHRCRYCGKVFGSDSALQIHIRSHTGE 476
            :  :.|:|.            ||..||..    :|.||||:||:|.||||||||||||:||||||
Frog   427 SIGTTAEDLNSLRKSKPPSVTAFETKSTS----DEAFFKHKCRFCAKVFGSDSALQIHLRSHTGE 487

  Fly   477 RPFKCNVCGSRFTTKGNLKVHFQRHAQKFPHVPMNATPIPEHMDKFHPPLLDQMSPTDSSPNHSP 541
            ||||||:||:||:||||||||||||.:|:||:.||..|:|||:|..         ||.:...:..
Frog   488 RPFKCNICGNRFSTKGNLKVHFQRHKEKYPHIQMNPYPVPEHLDNI---------PTSTGIPYGM 543

  Fly   542 APPP-------LGSAPA----------SFPPAFPGLQNLYR--PPMEILKSLGAAAPHQYFPQEL 587
            :.||       |.:.|.          ..||..|.|.:..:  .|..|..|...|:|......|.
Frog   544 SIPPEKPVTNWLDTKPVLPTLTTSVGMPLPPTIPTLTSFIKTEEPQPIAISHPTASPPDSVKSET 608

  Fly   588 PTD--LRKPSPQLDEDEPQVKNEPVEEKDQREEHEQEMAECSEPEPEPLPLEVRIKEERVEEQEQ 650
            .|:  |:|.|...||.|..:   |:.:|   ||.:.:.::|
Frog   609 ATEPLLKKTSDLPDEAEAAM---PILDK---EEQQSQNSDC------------------------ 643

  Fly   651 VKQEDHRIEPRRTPSPSSEHRSPHHHRHSHMGYPPVVQPIQPAALMHPQSSPGSQSHLD-HLPTP 714
                                                :|.:..:|     .||.:.|.:. ..|.|
Frog   644 ------------------------------------IQNLNTSA-----CSPTTGSGISASFPNP 667

  Fly   715 GQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPAGGALPPGVPPPPHHHPHHMARSPFFNPIK 779
             .||...:.|..:||.                    ||.|
Frog   668 -LLPLMSEQFKAKFPF--------------------GGLL------------------------- 686

  Fly   780 HEMAALLPRPHSNDNSWENFIEVSNTCETMKLKELMKN--KKISDPNQCVVCDRVLSCKSALQMH 842
                                 :|:...||.||::|::|  ||.||||:||:|.|||||:|||:||
Frog   687 ---------------------DVAPASETSKLQQLVENIDKKSSDPNECVICRRVLSCQSALKMH 730

  Fly   843 YRTHTGERPFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQHIRLHT 907
            ||||||||||||:|||||||||||||||.:||:..||:|..|.||:|.||::||:|||||||:|.
Frog   731 YRTHTGERPFKCKICGRAFTTKGNLKTHYSVHRAMPPLRVQHSCPICQKKFTNAVVLQQHIRMHM 795

  Fly   908 GEPTDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHFGALPGGPGGPPGPNHGAHNGALGSES 972
            |                                      |.:|..|.....|:        ..||
Frog   796 G--------------------------------------GQIPNTPIAESYPD--------SMES 814

  Fly   973 SQGDMDDNMDCGEDYDDDVSSEHLSNSNLEQEGDRSRSGDDFKSLLFEQKLRIDAT-GVVNTNPV 1036
            ..|..|      |...||:  ::.|:.|:|...| |...|..||        :||: ..::::|:
Frog   815 DTGSFD------EKTIDDL--DNFSDENMEDCPD-SSVPDTPKS--------VDASQDSLSSSPL 862

  Fly  1037 RPR-SSASSHGHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSP 1100
            .|. ||.::..:.:...:|..:..:.||    .:|:.....|......|.:.......|.|:.||
Frog   863 PPEVSSITALENQMKLINAGLAEQLQAS----LKSTENGSIEGDGMTNDSSSLGGDMESQSAGSP 923

  Fly  1101 LPKEKPVSPPSLPRSPSGSSHASANILTSP-----------LPPTVGIDCLPPGLQHHLQQQHQH 1154
            ...|...|..:|  |||.|::   :.|.||           |.||.|:...|
Frog   924 AASESTYSMHAL--SPSNSTN---DYLKSPNTDEKIHRALSLDPTSGLSPTP------------- 970

  Fly  1155 LMQQQAAVAAAAAAQHHHHQQMAALHQHQEQLRREAAEAQQKAAAAAAAAAAAAAAQRQTPPQAR 1219
                                                           |...|.......|....:
Frog   971 -----------------------------------------------ANGGALDLTSSNTDKVIK 988

  Fly  1220 DQRQEGGPGAGPPPNPLMGARPPF---GMFPNLPLFPPATTQNMCNAMNQIAQSVMPAAPFNPLA 1281
            |:.              :|...||   |.:.|
Frog   989 DEH--------------LGVLFPFRERGKYKN--------------------------------- 1006

  Fly  1282 LSGVRGSTTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLTHKIRDMEQ 1346
                   |.|.||.|||.|.|||:||||||||||||.|::|:|||:||||||||||||::||:..
Frog  1007 -------TICDICGKTFACQSALDIHYRSHTKERPFICTVCNRGFSTKGNLKQHMLTHQMRDLPS 1064

  Fly  1347 ETF 1349
            :.|
Frog  1065 QLF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	17/21 (81%)
		C2H2 Zn finger	453..473	CDD:275368	16/19 (84%)
		zf-H2C2_2	465..490	CDD:290200	21/24 (88%)
		C2H2 Zn finger	481..501	CDD:275368	16/19 (84%)
		C2H2 Zn finger	826..846	CDD:275368	15/19 (79%)
		zf-H2C2_2	838..863	CDD:290200	22/24 (92%)
		zf-C2H2_2	854..922	CDD:289522	38/67 (57%)
		C2H2 Zn finger	854..874	CDD:275368	16/19 (84%)
		C2H2 Zn finger	886..906	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1291..1311	CDD:275368	14/19 (74%)
		zf-H2C2_2	1303..1328	CDD:290200	19/24 (79%)
		C2H2 Zn finger	1319..1339	CDD:275368	15/19 (79%)
sall1	NP_001090646.1	PHA03247	<278..683	CDD:223021	140/529 (26%)
		PRK10856	<326..>438	CDD:236776	26/128 (20%)
		SUF4-like	461..543	CDD:411020	57/90 (63%)
		C2H2 Zn finger	464..485	CDD:411020	17/20 (85%)
		C2H2 Zn finger	464..484	CDD:275368	16/19 (84%)
		C2H2 Zn finger	492..512	CDD:411020	16/19 (84%)
		C2H2 Zn finger	492..512	CDD:275368	16/19 (84%)
		C2H2 Zn finger	714..734	CDD:275368	15/19 (79%)
		zf-H2C2_2	726..751	CDD:404364	22/24 (92%)
		C2H2 Zn finger	742..762	CDD:275368	16/19 (84%)
		zf-C2H2	772..794	CDD:395048	15/21 (71%)
		C2H2 Zn finger	774..794	CDD:275368	14/19 (74%)
		C2H2 Zn finger	1009..1029	CDD:275370	14/19 (74%)
		SUF4-like	1012..>1056	CDD:411020	34/43 (79%)
		C2H2 Zn finger	1012..1030	CDD:411020	13/17 (76%)
		zf-C2H2	1035..1057	CDD:395048	16/21 (76%)
		C2H2 Zn finger	1037..1057	CDD:275370	15/19 (79%)
		C2H2 Zn finger	1037..1056	CDD:411020	14/18 (78%)
		SUF4-like	1140..>1187	CDD:411020
		C2H2 Zn finger	1142..1163	CDD:411020
		C2H2 Zn finger	1142..1162	CDD:275368
		C2H2 Zn finger	1170..1190	CDD:275368
		C2H2 Zn finger	1170..1187	CDD:411020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11161
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1525
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D130294at33208
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm48607
Panther	1	1.100	-	-	O	PTHR23233
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1943
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190