DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salm and znf516

DIOPT Version :9

Sequence 1:	NP_723670.2	Gene:	salm / 34569	FlyBaseID:	FBgn0261648	Length:	1365	Species:	Drosophila melanogaster
Sequence 2:	NP_001153141.1	Gene:	znf516 / 100003866	ZFINID:	ZDB-GENE-060503-194	Length:	1084	Species:	Danio rerio

Alignment Length:	1160	Identity:	230/1160 - (19%)
Similarity:	350/1160 - (30%)	Gaps:	387/1160 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 EPFFK-------------HRCRYCGKVFGSDSALQIHIRSHTGERPFKCNVCGSRFTTKGNLKVH 497
            |||.|             |.|..||:.|...|:|..|:|.||||:|:||..|..|...||:||.|
Zfish    12 EPFSKGGHDNPDVKKSRGHTCELCGRSFPFLSSLSQHMRKHTGEKPYKCPHCEHRSAQKGSLKAH 76

  Fly   498 FQRHAQKFPHVPMNATPIPEHMDKFH------PPLLDQ---MSPTDSS-------PNHSPAPPPL 546
            .:.|  |...:..:.....|.||:..      |.  ||   .|||:|:       ..........
Zfish    77 IRSH--KLDGLSQSGGGEEEDMDEEGEKEGGVPE--DQGSCSSPTESTSACNKVVSGEDATKMRK 137

  Fly   547 GSAPASFPPAFPGLQ----NLYRPPMEILKSLGAAAPHQYFPQELPTDLR---KPSPQLDEDEPQ 604
            .|......|...|.|    :|.|      |.|...|..:...|||...||   .|.....||:.|
Zfish   138 KSGKKERIPGESGKQSVQCSLCR------KRLSGQAELEKHMQELHKVLRCELCPYETQQEDQLQ 196

  Fly   605 V---KNEPVEEKDQREE-------------HEQEMAECSEPEPEPLPLEVRIKEERVEEQEQVKQ 653
            .   |:.|.:|:...:|             .|....:|.:...:...|:..:|:.:       ..
Zfish   197 AHVEKDHPSDEESITKEVSTSEETDGILGKGEFPCEQCDQVFTQAWCLKTHMKKHQ-------NS 254

  Fly   654 EDH--RIEPRRTPSP--SSEHRSPHHHR---HSHMGYPPVVQPI--------------------- 690
            .||  ||..||...|  ...|...|:.:   .|:...|..|..:
Zfish   255 MDHGCRICGRRFREPWFLRSHMKTHNTKVKPRSNSYLPATVNEVAQDESNLVNEVCLYELCAKCG 319

  Fly   691 -----QPAALMHPQSSPGSQSHLDHLPTPGQLPPREDFFAERFPLNFTTAKMLSPEHHSPVRSPA 750
                 :.:..:|.|.....:..|.:...      .|:.|......:|.....|.|..:  :.:|:
Zfish   320 NFFHDRKSLQLHEQVHKNIEQPLKNKNC------NENNFPSVTKTSFLQCLNLKPAGN--IENPS 376

  Fly   751 GGALPPGVPPPPHHHPHHMARSPFFNPIKHEMA------ALLPRPHSNDNSWENFIEVSNTCETM 809
            .|.:.              .|.|..:|:....|      ..|.........||..:..::.....
Zfish   377 EGTIG--------------KRIPELDPVSSYQAWQLATRGKLVEVTERSQGWEERLADADVAYDR 427

  Fly   810 KLKELM-----KNKKISDPNQCVVCDR-----VLSC----KSALQMHYRTHTGER---------- 850
            :..|.:     |.||..|....:...:     ...|    .|..:.:....||||
Zfish   428 EKGEYVLLRQDKRKKSLDSTVSIPTKKRRGAVTQGCTPDQHSNGEKNSHVSTGERSPENLSDSEY 492

  Fly   851 -------------PFKCRICGRAFTTKGNLKTHMAVHKIRPPMRNFHQCPVCHKKYSNALVLQQH 902
                         ..:|..||:.|.|:..:..||.:.               |......:.....
Zfish   493 RPTSRPSRKNSQKTSECLECGKGFRTQQQMVIHMLIR---------------HGGLGETIGGNGL 542

  Fly   903 IRLHTGEP---------------------TDLTPEQIQAAEIRDPPPSMMPGHFMNPFAAAAFHF 946
            .|..|..|                     ||..|...:..:.....||.:..|.....:|..
Zfish   543 FRKTTSSPSKTGESAGHFRDQRRAGFLGDTDKKPYTCEHCDFCTSEPSAIAAHIQTHQSAVR--- 604

  Fly   947 GALPGGPGGPPGPNHGAHNGALGSESSQGDMDDNMDCG----------EDYDDDVSSEH-----L 996
                         :.|..:.||.|..||.........|          :.|....:|.|     |
Zfish   605 -------------DWGQRSDALTSSLSQSQTHQTNHTGFPRLRNALLQQPYWPYTTSTHLERAAL 656

  Fly   997 SNSNLEQEGDRSR------SGDDFKSLLFEQKLRID----ATGVVNTNPVR---PRSSASSH--- 1045
            |::.|:.|.::|:      |.|..:|.|....:.:|    .:.::..|.||   |..|.::|
Zfish   657 SDAALKTEEEKSKGLEESSSTDKAESNLLNLSVDVDNKKEVSSILLNNLVRHQCPYCSYATHYPE 721

  Fly  1046 --------GHSVGSTSAPTSPSVHASSQVIKRSSSPARSEASQGALDLTPRAAPTSSSSSRSPLP 1102
                    .|.:.||:                               |.|:.||.:.......|.
Zfish   722 VLWIHQRIAHKIDSTT-------------------------------LVPKWAPKNGLKGPKTLL 755

  Fly  1103 --KEKPVSPPSL-----PRSPSGSSHASANILTSPLPPTVGIDCLPPG------LQHHLQQQHQH 1154
              |.:...||.|     |..|...|:.::       ||    ||.|.|      |...::.....
Zfish   756 DFKRRTGPPPFLEGKDCPSLPQMRSYRTS-------PP----DCSPGGTKKSKPLTSTVESSSSQ 809

  Fly  1155 LMQQQAAVAAAAAAQHHHHQ-------QMA-ALHQ---HQEQLRREAAEAQQ----KAAAAAAAA 1204
            ......|.|..|::....|:       ::| :.|:   ||....|..|..|:    |..:....:
Zfish   810 NKSWHTATAPGASSHSSKHKTSKSRTDELAGSKHKTDIHQNNSSRPMASPQKTGNPKTGSRVVES 874

  Fly  1205 A---------------------AAAAAQRQTPPQARDQRQEGGPGAGPPPNPLMGARPPFGMFPN 1248
            :                     ::.|...|||.::..|.|:....||..|...:|...|
Zfish   875 SLLPQEGLHFMLSSKHNLSDQRSSKAHAPQTPSKSDSQAQDTPSVAGYDPWNRLGLSGP------ 933

  Fly  1249 LPLFPPATTQNMCNAMNQIAQSVMPAAPF----NP---------------------LALSG-VRG 1287
               .|.:.::....|..  |:.|.....|    ||                     ||.|| .:|
Zfish   934 ---SPHSQSKRQSTADG--AEGVTDILSFLKNCNPHDLAALYHHWGYSSAMTEQAGLARSGSQQG 993

  Fly  1288 STTCGICYKTFPCHSALEIHYRSHTKERPFKCSICDRGFTTKGNLKQHMLT-HKI 1341
            ...|.:|.|:|...|....|.||||.||||:|..|....:.|||||.|:.| |::
Zfish   994 EYVCPVCRKSFNQPSHYRTHMRSHTGERPFQCRYCPYSASQKGNLKTHVQTVHRL 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salm	NP_723670.2	zf-C2H2	451..473	CDD:278523	9/21 (43%)
		C2H2 Zn finger	453..473	CDD:275368	8/19 (42%)
		zf-H2C2_2	465..490	CDD:290200	12/24 (50%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	826..846	CDD:275368	2/28 (7%)
		zf-H2C2_2	838..863	CDD:290200	8/47 (17%)
		zf-C2H2_2	854..922	CDD:289522	14/88 (16%)
		C2H2 Zn finger	854..874	CDD:275368	7/19 (37%)
		C2H2 Zn finger	886..906	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1291..1311	CDD:275368	7/19 (37%)
		zf-H2C2_2	1303..1328	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1319..1339	CDD:275368	9/20 (45%)
znf516	NP_001153141.1	C2H2 Zn finger	32..52	CDD:275368	8/19 (42%)
		zf-H2C2_2	44..69	CDD:290200	12/24 (50%)
		C2H2 Zn finger	60..80	CDD:275368	8/19 (42%)
		C2H2 Zn finger	231..251	CDD:275368	3/19 (16%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		racA	319..446	CDD:237292	21/148 (14%)
		zf-C2H2	995..1017	CDD:278523	7/21 (33%)
		C2H2 Zn finger	997..1017	CDD:275368	7/19 (37%)
		zf-H2C2_2	1009..1034	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1025..1046	CDD:275368	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840