DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and Sall4

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_780512.2	Gene:	Sall4 / 99377	MGIID:	2139360	Length:	1067	Species:	Mus musculus

Alignment Length:	1293	Identity:	328/1293 - (25%)
Similarity:	483/1293 - (37%)	Gaps:	408/1293 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DTLLAKELDADSNNNGTEPQMEAEAVPESDTERETA----------------------------- 78
            :.|.|:|..|..|:.|...:...:::|.....||..
Mouse    32 EALAAEEPGAPVNSPGNCDEASEDSIPVKRPRREDTHICNKCCAEFFSLSEFMEHKKSCTKTPPV 96

  Fly    79 ----EERGEEQEPENSNEALDLSLISSGGRESLPGSG---------------------------- 111
                :..|.....:.|..||...|.|...::||..:|
Mouse    97 LIMNDSEGPVPSEDFSRAALSHQLGSPSNKDSLQENGSSSGDLKKLGTDSILYLKTEATQPSTPQ 161

  Fly   112 -------------HVSLEALQHTKVAVAQFAATA-MAGNHQSADLAMVQSTIFNVQRQHLMQLQL 162
                         :|:|:||:.|||||.|..|.| ||....:..:..|...|..:|:|.|.|:||
Mouse   162 DISYLPKGKVANTNVTLQALRGTKVAVNQRGAEAPMAPMPAAQGIPWVLEQILCLQQQQLQQIQL 226

  Fly   163 IQHLQSQLKRAEAAALGRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREE 227
            .:.::.|:....|.||    ||.      ....:..|..::.:.:::.:.|...:.....|::..
Mouse   227 TEQIRVQVNMWAAHAL----HSG------VAGADTLKALSSHVSQQVSVSQQVSAAVALLSQKAS 281

  Fly   228 NSKTDKRGTEDRKAEPEGYQSMMCDISSSLAS------------SIITNHDPPPAPNEPNCLEML 280
            |........:..|.......|....:||.|.|            :.::.......|..|..:.:.
Mouse   282 NPALSLDALKQAKLPHASVPSAASPLSSGLTSFTLKPDGTRVLPNFVSRLPSALLPQTPGSVLLQ 346

  Fly   281 QRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTG 345
            ...:...||.:.:.....|.....:.....:|:....:.||:|:||.|:||:.|:||||||||||
Mouse   347 SPFSAVTLDQSKKGKGKPQNLSASASVLDVKAKDEVVLGKHKCRYCPKVFGTDSSLQIHLRSHTG 411

  Fly   346 ERPFVCNVCGSKFTTKGNLKVHYQRHTQI-FPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAP 409
            |||:||.:||.:||||||||||.|||.:: ..|.||       .....:|.|....:     :|.
Mouse   412 ERPYVCPICGHRFTTKGNLKVHLQRHPEVKANPQLL-------AEFQDKGAVSAASH-----YAL 464

  Fly   410 PVAPVGQEQHQNQVE-EPEEIRQEIPVPQAEDLSKPMVKEKEKSHSPVERVKTPKEVKTDAALPS 473
            || ||..::....|: ||      :||.....|..|    ::.:..|..|......:..|  :..
Mouse   465 PV-PVPADESSLSVDAEP------VPVTGTPSLGLP----QKLTSGPNSRDLMGGSLPND--MQP 516

  Fly   474 SEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEY 538
            ...||.|...|::..    |.:.       :||                  :.........|
Mouse   517 GPSPESEAGLPLLGV----GMIH-------NPP------------------KAGGFQGTGAP--- 549

  Fly   539 SLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTH 603
                               :..|||.||||||:||:...||||:|:.|.:|:||:|||:||.|||
Mouse   550 -------------------ESGSETLKLQQLVENIDKATTDPNECLICHRVLSCQSSLKMHYRTH 595

  Fly   604 TGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDG 668
            ||||||:||||||||:||||||.|:.:|:....:::|..||:|.:||:|.::||||||:|
Mouse   596 TGERPFQCKICGRAFSTKGNLKTHLGVHRTNTTVKTQHSCPICQKKFTNAVMLQQHIRMH----- 655

  Fly   669 SGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFS----TTISDHSGQ----RSESSQGGDFD 725
            .|||......|                   ....||:    ..:|::...    :.::::|.:.:
Mouse   656 MGGQIPNTPLP-------------------ESPCDFTAPEPVAVSENGSASGVCQDDAAEGMEAE 701

  Fly   726 EFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMP 790
            |..:.|                                :|              :|..:.|..:|
Mouse   702 EVCSQD--------------------------------VP--------------SGPSTVSLPVP 720

  Fly   791 AMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFP 855
            :..|:|||        .|.:..|:....|.|.||.|.       |...::||.....|
Mouse   721 SAHLASPS--------LGFSVLASLDTQGKGALPALA-------LQRQSSRENSSLEG------- 763

  Fly   856 LLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRPQCSDAGSPYGAKL 920
                |..|      |.|..:|.      :...|...:|..|.|.....|..|..|.|||
Mouse   764 ----GDTG------PANDSSLL------VGDQECQSRSPDATETMCYQAVSPANSQAGS------ 806

  Fly   921 TLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTG 985
                        ..|.|..|.|                              .||..:......|
Mouse   807 ------------VKSRSPEGHK------------------------------AEGVESCRVDTEG 829

  Fly   986 ATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVN---NKHFCHVCRR 1047
            .|| .|.....|:.:.:|:::.. .|...|     ::.|..||..:..|...   .:|.|..|.:
Mouse   830 RTS-LPPTFIRAQPTFVKVEVPG-TFVGPP-----SMPSGMPPLLASQPQPRRQAKQHCCTRCGK 887

  Fly  1048 NFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTNPTSRRGRRMSLELPMRPG 1112
            ||||:||||||.|||||:|||.||:|.:|||||||||||..||...|.::||||::::|.||
Mouse   888 NFSSASALQIHERTHTGEKPFVCNICGRAFTTKGNLKVHYMTHGANNNSARRGRKLAIENPM--- 949

  Fly  1113 PNSGQGHPGSSAEQEFMQRRPELFFPYL--------PPFFN--------GLPPKPGELS---PGA 1158
                   ...|||.   :|.||:|...|        |..:|        ||..|..|:|   .|.
Mouse   950 -------AALSAEG---KRAPEVFSKELLSPAVSVDPASWNQYTSVLNGGLAMKTNEISVIQSGG 1004

  Fly  1159 FPNIP-------------------------PPPFANGGKYPYPPGLL--GFPGFLAQH 1189
            .|.:|                         .|...||.|...|.|:.  .||.||.::
Mouse  1005 IPTLPVSLGASSVVSNGTISKLDGSQTGVSMPMSGNGEKLAVPDGMAKHQFPHFLEEN 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	14/21 (67%)
		C2H2 Zn finger	323..343	CDD:275368	13/19 (68%)
		zf-H2C2_2	335..360	CDD:290200	18/24 (75%)
		C2H2 Zn finger	351..371	CDD:275368	14/19 (74%)
		C2H2 Zn finger	583..603	CDD:275368	11/19 (58%)
		zf-H2C2_2	595..620	CDD:290200	21/24 (88%)
		C2H2 Zn finger	611..631	CDD:275368	15/19 (79%)
		C2H2 Zn finger	643..663	CDD:275368	12/19 (63%)
		lambda-1	1013..>1061	CDD:212564	18/50 (36%)
		zf-C2H2	1040..1062	CDD:278523	14/21 (67%)
		C2H2 Zn finger	1042..1062	CDD:275368	13/19 (68%)
		zf-H2C2_2	1054..1079	CDD:290200	18/24 (75%)
		C2H2 Zn finger	1070..1090	CDD:275368	14/19 (74%)
Sall4	NP_780512.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..140		7/24 (29%)
		zf-C2H2	387..409	CDD:278523	14/21 (67%)
		C2H2 Zn finger	389..409	CDD:275368	13/19 (68%)
		zf-H2C2_2	401..426	CDD:290200	18/24 (75%)
		C2H2 Zn finger	417..437	CDD:275368	14/19 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	471..521		10/61 (16%)
		C2H2 Zn finger	575..595	CDD:275368	11/19 (58%)
		zf-H2C2_2	587..612	CDD:290200	21/24 (88%)
		C2H2 Zn finger	603..623	CDD:275368	15/19 (79%)
		zf-C2H2	633..655	CDD:278523	12/21 (57%)
		C2H2 Zn finger	635..655	CDD:275368	12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	682..716		5/79 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..835		27/154 (18%)
		lambda-1	796..>901	CDD:212564	37/159 (23%)
		C2H2 Zn finger	882..902	CDD:275368	13/19 (68%)
		zf-H2C2_2	894..919	CDD:290200	18/24 (75%)
		C2H2 Zn finger	910..930	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11965
eggNOG	1	0.900	-	-		E1_KOG1074
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001008
OrthoInspector	1	1.000	-	-		otm43008
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23233
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8600
SonicParanoid	1	1.000	-	-		X498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.900