DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF536

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	XP_011525856.1	Gene:	ZNF536 / 9745	HGNCID:	29025	Length:	1408	Species:	Homo sapiens

Alignment Length:	1247	Identity:	243/1247 - (19%)
Similarity:	398/1247 - (31%)	Gaps:	430/1247 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 EPEPEPEPKKQPTNG---LKEEL------------ELEQGPESEQDQESRREENSKTDKRGTEDR 239
            |||.||.......||   :.::|            ||...|..|:...:..||.:.....|
Human    14 EPEAEPHLSGPVLNGQYAMSQKLHQITSQLSHAFPELHPRPNPEEKPPASLEEKAHVPMSG---- 74

  Fly   240 KAEPEGYQSMMCDISSSLASSIITNHDPPPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEY 304
              :|.|  |.|..:::.|...:.|:               |..|.:.......|:|.......:.
Human    75 --QPMG--SQMALLANQLGREVDTS---------------LNGRVDLQQFLNGQNLGIMSQMSDI 120

  Fly   305 SEYASKEAQSRGEIFKHRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQ 369
            .:.|.|..       |:.|..|||.|...|.|.:|:|:||||:||.|..|..:...|||||:|.:
Human   121 EDDARKNR-------KYPCPLCGKRFRFNSILSLHMRTHTGEKPFKCPYCDHRAAQKGNLKIHLR 178

  Fly   370 RHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIP 434
            .|.            ..|:| .|:|:|:.|...:            .|..:..:...::::..:.
Human   179 THK------------LGNLG-KGRGRVREENRLL------------HELEERAILRDKQLKGSLL 218

  Fly   435 VPQAEDLSKPMVKEK----------EKSHS------PVERVKTPKEVKTDAALPSSEKPEKEISK 483
            .|: .||..|...::          :.:||      ||...| |..|:.||..|::.
Human   219 QPR-PDLKPPPHAQQAPLAACTLALQANHSVPDVAHPVPSPK-PASVQEDAVAPAAG-------- 273

  Fly   484 PVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERIID 548
              ...:...|..:||:             :|..|:.|.....:.:.      .:::.:|.|.:|.
Human   274 --FRCTFCKGKFKKRE-------------ELDRHIRILHKPYKCTL------CDFAASQEEELIS 317

  Fly   549 KSWEDLIEIDK---TSETSKLQQLVDNIENKLTDPN----------QCIFCQKVMSCRSSLQMHI 600
                   .::|   |:|:::.|           .||          :|..|.:|.|....|:.|:
Human   318 -------HVEKAHITAESAQGQ-----------GPNGGGEQSANEFRCEVCGQVFSQAWFLKGHM 364

  Fly   601 RTHTGERPFRCKICGRAFATKGNLKAHMSIH------KIKPPMRSQFKCPVCHQKFSNGIILQQH 659
            |.|.......|:||||.|.....||.||.:|      |.|.|...:...|:      .|:..:.|
Human   365 RKHKDSFEHCCQICGRRFKEPWFLKNHMKVHLNKLSVKNKSPSDPEVPVPM------GGMSQEAH 423

  Fly   660 IRIHT----------MDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTTISD-HS- 712
            ..:::          |.....|...|:...|:.|....|.:...|.|....::.......| ||
Human   424 ANLYSRYLSCLQSGFMTPDKAGLSEPSQLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSL 488

  Fly   713 ---------------GQRSESSQGGDFDEF------------MTMDSTDDSRDNSSAATATPHPL 750
                           .:...:::..:.|..            |.|:....|::         |||
Human   489 LGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKE---------HPL 544

  Fly   751 ERERDR---------EKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFA 806
            :|..:.         :||:...:              |.|......:|||..:.|....|.|
Human   545 QRNHEDTLANAGVLFDKEKREYV--------------LVGADGSKQKMPADLVHSTKVGSQR--- 592

  Fly   807 TGLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPP 871
                                  .:|..|..:.::|:.:     :|.....|.:...|...:...|
Human   593 ----------------------DLPSKLDPLESSRDFL-----SHGLNQTLEYNLQGPGNMKEKP 630

  Fly   872 NVCNLCFKMLPSL--AALESHLQSEHAKEPATG-HAQRPQCSDAGSPYGAKLTLNPNLFAKKPPS 933
            ..|..|.::..:.  ..:.|.:.....|....| |....:...:||                 ..
Human   631 TECPDCGRVFRTYHQVVVHSRVHKRDRKGEEDGLHVGLDERRGSGS-----------------DQ 678

  Fly   934 SSSSSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAE 998
            .|.|.|....|.|||                      :.||   :|.|.|...|       |.|:
Human   679 ESQSVSRSTTPGSSN----------------------VTEE---SGVGGGLSQT-------GSAQ 711

  Fly   999 QSLMKMQLHAHRFPASPLDF---QQALMSAG--PPTSSLDPPVNN-KHFCHVCRRNFSSSSALQI 1057
            :.      ..|  |:||...   ::|..|||  .|....|..:.: ...|..|.:.|.:|..|::
Human   712 ED------SPH--PSSPSSSDIGEEAGRSAGVQQPALLRDRSLGSAMKDCPYCGKTFRTSHHLKV 768

  Fly  1058 HMRTHT-----------------------------GDKPFQCNVCQKAFTTKGNLKVHMGTHMWT 1093
            |:|.||                             |:||::|..|..|.|...:||.|:..|
Human   769 HLRIHTVCVHTIPNRKERSDLYSQVVLAQPPGNLKGEKPYKCPHCDYAGTQSASLKYHLERH--- 830

  Fly  1094 NPTSRRGRRMSLELPMRPGPNSGQGHPGSSAEQEFMQRRPELFFPYLPPFFNGLPPKPGELSPGA 1158
                .|.|:..      .||.|||  |.:...::.|..:..||.            :| ::..||
Human   831 ----HRERQNG------AGPLSGQ--PPNQDHKDEMSSKASLFI------------RP-DILRGA 870

  Fly  1159 FPNIPPPPFANG-GKYPYPPGLLG-------FPGFLAQHPYILERRSSSKSPTPEPAQSPALREE 1215
            |..:|...|..| ....:..|:|.       ..|..::.|      |.:...|..|::|....|
Human   871 FKGLPGIDFRGGPASQQWTSGVLSSGDHSGQATGMSSEVP------SDALKGTDLPSKSTHFSE- 928

  Fly  1216 EGSGNIWHPLSRIKVENNQN--------------ESMGGFNEQEDHAETD--------ATGGD-- 1256
              .|..:..:    |.|..|              .|:....:.:|.|..|        ..||:
Human   929 --IGRAYQSI----VSNGVNFQGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEK 987

  Fly  1257 -NDESESRDAEK 1267
             :.:|..|.:||
Human   988 PSGKSSQRKSEK 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	9/21 (43%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		zf-H2C2_2	595..620	CDD:290200	10/24 (42%)
		C2H2 Zn finger	611..631	CDD:275368	10/19 (53%)
		C2H2 Zn finger	643..663	CDD:275368	3/19 (16%)
		lambda-1	1013..>1061	CDD:212564	14/53 (26%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/53 (21%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
ZNF536	XP_011525856.1	COG5048	103..>180	CDD:227381	28/83 (34%)
		C2H2 Zn finger	132..152	CDD:275368	9/19 (47%)
		zf-H2C2_2	145..169	CDD:404364	11/23 (48%)
		C2H2 Zn finger	160..180	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..297	CDD:275368	6/33 (18%)
		C2H2 Zn finger	302..323	CDD:275368	4/33 (12%)
		zf-C2H2	345..367	CDD:395048	7/21 (33%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		zf-C2H2	373..395	CDD:395048	10/21 (48%)
		C2H2 Zn finger	375..395	CDD:275368	10/19 (53%)
		zf-C2H2_assoc	657..737	CDD:406903	28/136 (21%)
		C2H2 Zn finger	753..773	CDD:275368	7/19 (37%)
		zf-C2H2	753..773	CDD:395048	7/19 (37%)
		zf-H2C2_5	808..831	CDD:404746	8/29 (28%)
		C2H2 Zn finger	810..830	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910