DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF235

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_004225.3	Gene:	ZNF235 / 9310	HGNCID:	12866	Length:	738	Species:	Homo sapiens

Alignment Length:	1103	Identity:	205/1103 - (18%)
Similarity:	309/1103 - (28%)	Gaps:	494/1103 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 QMEAEAVPESDTERETAEERGEEQEPENSNEALDLSLISSGGRESLPGSGHVSLEALQHTKVAVA 126
            |:|.|   |....:|...:||:.....|.||   ::.:...|....      ||..|...::.
Human    59 QLERE---EKLWMKELQTQRGKHSGDRNQNE---MATLHKAGLRCF------SLGELSCWQIK-- 109

  Fly   127 QFAATAMAGNHQSADLAMVQSTIFNVQRQHLMQLQLIQHLQS--QLKRAEAAA-----------L 178
                     .|.::.||..|.::.|::.:   ..|..:|..|  |:...|:..           :
Human   110 ---------RHIASKLARSQDSMINIEGK---SSQFPKHHDSPCQVGAGESIQASVDDNCLVNHI 162

  Fly   179 GRHSHSDEEEEEPEPEPEPKKQPTNGLKEELELEQGPESEQDQESRREENSKTDKRGTEDRKAEP 243
            |.||...|.:|.|     ..|.|.:..|..|.     |::..|.|.::...|
Human   163 GDHSSIIENQEFP-----TGKVPNSWSKIYLN-----ETQNYQRSCKQTQMK------------- 204

  Fly   244 EGYQSMMC------DISSSLASSIITN--HDPPPAPNEPNC------LEMLQRRT---------- 284
                :.:|      ||.|.::.....|  |......:..:|      :..|.:|:
Human   205 ----NKLCIFAPYVDIFSCISHHHDDNIVHKRDKVHSNSDCGKDTLKVSPLTQRSIHTGQKTYQG 265

  Fly   285 ---EEVL-DSASQSLH----------AAQMQEEYSEYAS----KEAQSRGEIFKHRCKYCGKIFG 331
               ||.. ||:|..||          |....|:.:.|:|    :::...|: .::.|..|||.|.
Human   266 NECEEAFNDSSSLELHKQVHLGKKSPACSTHEKDTSYSSGIPVQQSVRTGK-KRYWCHECGKGFS 329

  Fly   332 SYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAP-NVGHSGQGQ 395
            ..|.||.|.|.||||:|:.|:.||..|....:|..|...||          |..| .....|:|.
Human   330 QSSNLQTHQRVHTGEKPYTCHECGKSFNQSSHLYAHLPIHT----------GEKPYRCDSCGKGF 384

  Fly   396 VQGEQYPIRL-------PFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSH 453
            .:.....|..       |:...|...|..|                                :||
Human   385 SRSTDLNIHCRVHTGEKPYKCEVCGKGFTQ--------------------------------RSH 417

  Fly   454 SPV-ERVKTPKEVKTDAALPSSEKPEKEISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEH 517
            ... ||:.|            .|||.|            .|...||.:.:             .:
Human   418 LQAHERIHT------------GEKPYK------------CGDCGKRFSCS-------------SN 445

  Fly   518 LHIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKL----- 577
            ||..:.|.     .|.:|.                      |..|..|...|..|:.:..
Human   446 LHTHQRVH-----TEEKPY----------------------KCDECGKCFSLSFNLHSHQRVHTG 483

  Fly   578 TDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFK 642
            ..|.:|..|.|..|..||.|.|.|.||||:||||.:||:.|:.....:||..:|..:.|    :|
Human   484 EKPYKCEECGKGFSSASSFQSHQRVHTGEKPFRCNVCGKGFSQSSYFQAHQRVHTGEKP----YK 544

  Fly   643 CPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSDTLDFSTT 707
            |.||.::|:..:.|..|.|:||           ...|.:.|..|         .|.|...:....
Human   545 CEVCGKRFNWSLNLHNHQRVHT-----------GEKPYKCEECG---------KGFSQASNLQAH 589

  Fly   708 ISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSDER 772
            .|.|:|::
Human   590 QSVHTGEK--------------------------------------------------------- 597

  Fly   773 SHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLLLM 837

Human   598 ----------------------------------------------------------------- 597

  Fly   838 AAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPATG 902
                                             |..|:.|.|.....:.|::| |..|     ||
Human   598 ---------------------------------PFKCDACQKRFSQASHLQAH-QRVH-----TG 623

  Fly   903 HAQRP-QCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDPD 966
              ::| :|...|..:..:..|..:...         .:|||       ||..
Human   624 --EKPYKCDTCGKAFSQRSNLQVHQII---------HTGEK-------PFKC------------- 657

  Fly   967 QEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTSS 1031
             |:...|...|||                          |.||          |.:.:...|
Human   658 -EECGKEFSWSAG--------------------------LSAH----------QRVHTGEKP--- 682

  Fly  1032 LDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTHMWTN 1094
                    :.|..|.:.||.:|....|.|.|||::|:.|:||.|.|:.:.:|..|...|...|
Human   683 --------YTCQQCGKGFSQASHFHTHQRVHTGERPYICDVCCKGFSQRSHLIYHQRVHTGGN 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/21 (48%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	13/24 (54%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	15/24 (63%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	8/47 (17%)
		zf-C2H2	1040..1062	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1042..1062	CDD:275368	7/19 (37%)
		zf-H2C2_2	1054..1079	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1070..1090	CDD:275368	7/19 (37%)
ZNF235	NP_004225.3	KRAB A domain	6..47
		KRAB	8..68	CDD:214630	4/11 (36%)
		KRAB	8..47	CDD:279668
		KRAB B domain	48..80		7/23 (30%)
		C2H2 Zn finger	266..285	CDD:275368	7/18 (39%)
		COG5048	321..662	CDD:227381	117/663 (18%)
		C2H2 Zn finger	321..341	CDD:275368	10/19 (53%)
		zinc finger domain	321..341		10/19 (53%)
		zf-H2C2_2	333..358	CDD:290200	13/24 (54%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		zinc finger domain	349..369		6/19 (32%)
		C2H2 Zn finger	377..397	CDD:275368	3/19 (16%)
		zinc finger domain	377..397		3/19 (16%)
		zf-H2C2_2	389..414	CDD:290200	4/24 (17%)
		C2H2 Zn finger	405..425	CDD:275368	7/51 (14%)
		zinc finger domain	405..425		7/51 (14%)
		zf-H2C2_2	417..442	CDD:290200	11/48 (23%)
		C2H2 Zn finger	433..453	CDD:275368	5/32 (16%)
		zinc finger domain	433..453		5/32 (16%)
		zf-H2C2_2	448..469	CDD:290200	6/47 (13%)
		C2H2 Zn finger	461..481	CDD:275368	4/19 (21%)
		zinc finger domain	461..481		4/19 (21%)
		zf-H2C2_2	476..498	CDD:290200	4/21 (19%)
		C2H2 Zn finger	489..509	CDD:275368	9/19 (47%)
		zinc finger domain	489..509		9/19 (47%)
		zf-H2C2_2	501..526	CDD:290200	15/24 (63%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		zinc finger domain	517..537		6/19 (32%)
		zf-H2C2_2	529..553	CDD:290200	8/27 (30%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		zinc finger domain	545..565		7/19 (37%)
		zf-H2C2_2	560..582	CDD:290200	8/41 (20%)
		C2H2 Zn finger	573..593	CDD:275368	5/28 (18%)
		zinc finger domain	573..593		5/28 (18%)
		zf-H2C2_2	585..610	CDD:290200	7/179 (4%)
		C2H2 Zn finger	601..621	CDD:275368	6/20 (30%)
		zinc finger domain	601..621		6/20 (30%)
		zf-H2C2_2	613..638	CDD:290200	9/32 (28%)
		C2H2 Zn finger	629..649	CDD:275368	3/28 (11%)
		zinc finger domain	629..649		3/28 (11%)
		zf-H2C2_2	641..665	CDD:290200	8/53 (15%)
		C2H2 Zn finger	657..677	CDD:275368	9/69 (13%)
		zinc finger domain	657..677		9/69 (13%)
		zf-H2C2_2	670..694	CDD:290200	8/44 (18%)
		C2H2 Zn finger	685..705	CDD:275368	7/19 (37%)
		zinc finger domain	685..705		7/19 (37%)
		C2H2 Zn finger	713..733	CDD:275368	7/19 (37%)
		zinc finger domain	713..733		7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910