DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment salr and ZNF226

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens

Alignment Length:	805	Identity:	163/805 - (20%)
Similarity:	257/805 - (31%)	Gaps:	337/805 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 QSLHAAQMQEEYSEYASKEAQSRGEIFK--HRCKYCGKIFGSYSALQIHLRSHTGERPFVCNVCG 355
            :.|...:..:|:|:.|..:...:..:.:  ::||.|||.|...|||.:|.:.||.|:|:.|..||
Human   305 EKLKCDECGKEFSQGAHLQTHQKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHTAEKPYNCEECG 369

  Fly   356 SKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGHSGQGQVQGEQYPIRLPFAPPVAPVGQEQHQ 420
            ..|:...:|:.|.:.||                         ||:     ||
Human   370 RAFSQASHLQDHQRLHT-------------------------GEK-----PF------------- 391

  Fly   421 NQVEEPEEIRQEIPVPQAEDLSKPMVKEKE-KSHSPVERVKTPKEVKTDAALPSSEKPEK--EIS 482
                            :.:...|...:... :||   :||.|            .|||.|  |..
Human   392 ----------------KCDACGKSFSRNSHLQSH---QRVHT------------GEKPYKCEECG 425

  Fly   483 KPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHLHIAKLVRRSSASRESQPAEYSLAQMERII 547
            |..:.||  |..:.:|..:...|.:.:         ...|...|.|:.:..|...
Human   426 KGFICSS--NLYIHQRVHTGEKPYKCE---------ECGKGFSRPSSLQAHQGVH---------- 469

  Fly   548 DKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQCIFCQKVMSCRSSLQMHIRTHTGERPFRCK 612
                        |.|.|.:                |..|.|..:..|:||.|.|.||||:|::|.
Human   470 ------------TGEKSYI----------------CTVCGKGFTLSSNLQAHQRVHTGEKPYKCN 506

  Fly   613 ICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQKFSNGIILQQHIRIHTMDDGSGGQGAPAA 677
            .||::|....:.:.|:.:|..:.|    :||.:|.:.||....||.|.:.|:::
Human   507 ECGKSFRRNSHYQVHLVVHTGEKP----YKCEICGKGFSQSSYLQIHQKAHSIE----------- 556

  Fly   678 NPGEAERLGIEDQNSNKSLGTSDTLDFSTTISDHSGQRSESSQGGDFDEFMTMDSTDDSRDNSSA 742
            .|.:.|..|   |..|:    |..|.....|  |:|::
Human   557 KPFKCEECG---QGFNQ----SSRLQIHQLI--HTGEK--------------------------- 585

  Fly   743 ATATPHPLERERDREKERERRIPNDCSDERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFAT 807
                |:..|   :..|...||     :|.:.|.       |..:||.|     ......|::|
Human   586 ----PYKCE---ECGKGFSRR-----ADLKIHC-------RIHTGEKP-----YNCEECGKVF-- 624

  Fly   808 GLANGAAGGGSGNGGLPMLGMPMPPNLLLMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPN 872
                                             |:..:.|.|........||
Human   625 ---------------------------------RQASNLLAHQRVHSGEKPF------------- 643

  Fly   873 VCNLCFKMLPSLAALESHLQSEHAKEPATGHAQRP-QCSDAGSPYGAKLTLNPNLFAKKPPSSSS 936
            .|..|.|.....|.|::| |..|     ||  .:| :|.:.|.  |.|.:||.::..:
Human   644 KCEECGKSFGRSAHLQAH-QKVH-----TG--DKPYKCDECGK--GFKWSLNLDMHQR------- 691

  Fly   937 SSSGEKLPESSNPPFPAENPPATPIKEDPDQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSL 1001
            ..:|||                                                |.:.|:..:..
Human   692 VHTGEK------------------------------------------------PYKCGECGKYF 708

  Fly  1002 MKMQLHAHRFPASPLDFQQALMSAGPPTSSLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDK 1066
            .:         ||.|...|::.:...|           :.|.||.:.||.||.||.|.|.|||:|
Human   709 SQ---------ASSLQLHQSVHTGEKP-----------YKCDVCGKVFSRSSQLQSHQRVHTGEK 753

  Fly  1067 PFQCNVCQKAFTTKGNLKVHMGTHM 1091
            |::|.:|.|:|:.:.||.||...|:
Human   754 PYKCEICGKSFSWRSNLTVHHRIHV 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/21 (48%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	11/24 (46%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		zf-H2C2_2	595..620	CDD:290200	13/24 (54%)
		C2H2 Zn finger	611..631	CDD:275368	5/19 (26%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	15/47 (32%)
		zf-C2H2	1040..1062	CDD:278523	11/21 (52%)
		C2H2 Zn finger	1042..1062	CDD:275368	11/19 (58%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370
		SUF4-like	306..>357	CDD:411020	14/50 (28%)
		C2H2 Zn finger	309..334	CDD:411020	3/24 (13%)
		C2H2 Zn finger	309..329	CDD:275368	3/19 (16%)
		C2H2 Zn finger	337..357	CDD:411020	10/19 (53%)
		C2H2 Zn finger	337..357	CDD:275368	10/19 (53%)
		COG5048	359..774	CDD:227381	145/745 (19%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	4/22 (18%)
		C2H2 Zn finger	421..441	CDD:275368	6/21 (29%)
		C2H2 Zn finger	449..469	CDD:275368	4/28 (14%)
		C2H2 Zn finger	477..497	CDD:275368	8/19 (42%)
		C2H2 Zn finger	505..525	CDD:275368	5/19 (26%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	7/28 (25%)
		C2H2 Zn finger	589..609	CDD:275368	7/34 (21%)
		C2H2 Zn finger	617..637	CDD:275368	5/54 (9%)
		C2H2 Zn finger	645..665	CDD:275368	7/20 (35%)
		C2H2 Zn finger	673..693	CDD:275368	6/28 (21%)
		C2H2 Zn finger	701..721	CDD:275368	5/28 (18%)
		C2H2 Zn finger	729..749	CDD:275368	11/19 (58%)
		C2H2 Zn finger	757..777	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000