DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment salr and ZNF135

DIOPT Version :9

Sequence 1:	NP_001245983.1	Gene:	salr / 34568	FlyBaseID:	FBgn0000287	Length:	1267	Species:	Drosophila melanogaster
Sequence 2:	NP_009065.1	Gene:	ZNF135 / 7694	HGNCID:	12919	Length:	682	Species:	Homo sapiens

Alignment Length:	970	Identity:	198/970 - (20%)
Similarity:	269/970 - (27%)	Gaps:	435/970 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 PKKQPTNGLKEELE-------LEQG--PESE--------QDQESRREENSKTDKRGTED------ 238
            ||....:.|::|.|       |.||  ||.:        .|.|:|.:......|:|..:
Human    70 PKPNVISLLEQEAELWAVESRLPQGVYPEIKGHFQFLLLSDLETRPKVKLSVLKQGISEEISNSV 134

  Fly   239 --------------RKAEPEGYQSMMCDISSSLA----------------------SSIITNHDP 267
                          |..:.||:....|:...|||                      .:|..|.|.
Human   135 ILVERFLWDGLWYCRGEDTEGHWEWSCESLESLAVPVAFTPVKTPVLEQWQRNGFGENISLNPDL 199

  Fly   268 PPAPNEPNCLEMLQRRTEEVLDSASQSLHAAQMQEEYSEYASKEAQSRGEIFK-------HRCKY 325
            |..|..|.                .||.|.      :.....:|......:.|       ::|:.
Human   200 PHQPMTPE----------------RQSPHT------WGTRGKREKPDLNVLQKTCVKEKPYKCQE 242

  Fly   326 CGKIFGSYSALQIHLRSHTGERPFVCNVCGSKFTTKGNLKVHYQRHTQIFPPMLLPPGVAPNVGH 390
            |||.|...|||..|.|:||||||:.|:.|...|.....|..|.:.||...|......|...|
Human   243 CGKAFSHSSALIEHHRTHTGERPYECHECLKGFRNSSALTKHQRIHTGEKPYKCTQCGRTFN--- 304

  Fly   391 SGQGQVQGEQYPIRLPFAPPVAPVGQEQHQNQVEEPEEIRQEIPVPQAEDLSKPMVKEKEKSHSP 455
                               .:||:.|.|..:..|:|.|         ..:..|..  ....|.|.
Human   305 -------------------QIAPLIQHQRTHTGEKPYE---------CSECGKSF--SFRSSFSQ 339

  Fly   456 VERVKTPKEVKTDAALPSSEKPEK--EISKPVVTSSRRNGSVRKRQTSAVSPPQEDRERDLVEHL 518
            .||..|            .|||.:  |..|..            ||:.           .|.:||
Human   340 HERTHT------------GEKPYECSECGKAF------------RQSI-----------HLTQHL 369

  Fly   519 HIAKLVRRSSASRESQPAEYSLAQMERIIDKSWEDLIEIDKTSETSKLQQLVDNIENKLTDPNQC 583
            .|                                      .|.|                .|.||
Human   370 RI--------------------------------------HTGE----------------KPYQC 380

  Fly   584 IFCQKVMSCRSSLQMHIRTHTGERPFRCKICGRAFATKGNLKAHMSIHKIKPPMRSQFKCPVCHQ 648
            ..|.|..|..|||..|.|.||||:|:.|..||:||.....|..|...|..:.|    ::|..|.:
Human   381 GECGKAFSHSSSLTKHQRIHTGEKPYECHECGKAFTQITPLIQHQRTHTGEKP----YECGECGK 441

  Fly   649 KFSNGIILQQHIRIHTMDDGSGGQGAPAANPGEAERLGIEDQNSNKSLGTSD---TLDFSTTISD 710
            .||...:|.:|.||||               ||            |..|.::   |...|:::|.
Human   442 AFSQSTLLTEHRRIHT---------------GE------------KPYGCNECGKTFSHSSSLSQ 479

  Fly   711 ----HSGQRS-ESSQGGDFDEFMTMDSTDDSRDNSSAATATPHPLERERDREKERERRIPNDCSD 770
                |:|::. |.||.|                  .|...:.|..:.:|....|:.... |||..
Human   480 HERTHTGEKPYECSQCG------------------KAFRQSTHLTQHQRIHTGEKPYEC-NDCGK 525

  Fly   771 ERSHSNPDLTGGRSESGEMPAMDLSSPSSNSGRIFATGLANGAAGGGSGNGGLPMLGMPMPPNLL 835
            ..|||:......|..:||.|     ...:..||.|:. ||             |::
Human   526 AFSHSSSLTKHQRIHTGEKP-----YECNQCGRAFSQ-LA-------------PLI--------- 562

  Fly   836 LMAAAREEMHALGHAHAKFPLLPFGPLGFMGLHPPPNVCNLCFKMLPSLAALESHLQSEHAKEPA 900
                    .|...|...|                 |..||.|.:.....:.|..| |..|.||..
Human   563 --------QHQRIHTGEK-----------------PYECNQCGRAFSQSSLLIEH-QRIHTKEKP 601

  Fly   901 TGHAQRPQCSDAGSPYGAKLTLNPNLFAKKPPSSSSSSSGEKLPESSNPPFPAENPPATPIKEDP 965
            .|      |::.|..:                |.|||.|..:...:...|:.
Human   602 YG------CNECGKSF----------------SHSSSLSQHERTHTGEKPYE------------- 631

  Fly   966 DQEQLMVEEGASAGEGSGTGATSNYPQEAGDAEQSLMKMQLHAHRFPASPLDFQQALMSAGPPTS 1030

Human   632 ----------------------------------------------------------------- 631

  Fly  1031 SLDPPVNNKHFCHVCRRNFSSSSALQIHMRTHTGDKPFQCNVCQKAFTTKGNLKVHMGTH 1090
                       ||.|.::|..|:.|..|.|.|||:||:.|..|.||||...:|..|..||
Human   632 -----------CHDCGKSFRQSTHLTQHRRIHTGEKPYACRDCGKAFTHSSSLTKHQRTH 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
salr	NP_001245983.1	zf-C2H2	321..343	CDD:278523	10/21 (48%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..360	CDD:290200	13/24 (54%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	14/24 (58%)
		C2H2 Zn finger	611..631	CDD:275368	7/19 (37%)
		C2H2 Zn finger	643..663	CDD:275368	7/19 (37%)
		lambda-1	1013..>1061	CDD:212564	7/47 (15%)
		zf-C2H2	1040..1062	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1042..1062	CDD:275368	8/19 (42%)
		zf-H2C2_2	1054..1079	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1070..1090	CDD:275368	8/19 (42%)
ZNF135	NP_009065.1	KRAB	26..85	CDD:214630	5/14 (36%)
		KRAB	26..65	CDD:279668
		zf-C2H2	238..260	CDD:278523	10/21 (48%)
		C2H2 Zn finger	240..260	CDD:275368	10/19 (53%)
		COG5048	264..665	CDD:227381	143/737 (19%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		zf-H2C2_2	280..305	CDD:290200	7/46 (15%)
		C2H2 Zn finger	296..316	CDD:275368	6/41 (15%)
		C2H2 Zn finger	324..344	CDD:275368	5/21 (24%)
		zf-H2C2_2	339..361	CDD:290200	8/45 (18%)
		C2H2 Zn finger	352..372	CDD:275368	8/80 (10%)
		zf-H2C2_2	364..389	CDD:290200	11/78 (14%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		zf-H2C2_2	392..417	CDD:290200	14/24 (58%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		zf-H2C2_2	421..445	CDD:290200	7/27 (26%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	3/19 (16%)
		zf-H2C2_2	476..501	CDD:290200	8/42 (19%)
		C2H2 Zn finger	492..512	CDD:275368	6/37 (16%)
		zf-H2C2_2	504..529	CDD:290200	6/25 (24%)
		C2H2 Zn finger	520..540	CDD:275368	7/20 (35%)
		zf-H2C2_2	532..557	CDD:290200	7/29 (24%)
		C2H2 Zn finger	548..568	CDD:275368	7/50 (14%)
		zf-H2C2_2	561..585	CDD:290200	7/57 (12%)
		C2H2 Zn finger	576..596	CDD:275368	6/20 (30%)
		C2H2 Zn finger	604..624	CDD:275368	7/35 (20%)
		zf-H2C2_2	619..641	CDD:290200	5/110 (5%)
		C2H2 Zn finger	632..652	CDD:275368	8/19 (42%)
		zf-H2C2_2	644..669	CDD:290200	13/24 (54%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000